Conaz (20mg) 60ml Lotion

Ketoconazole inhibits synthesis of ergosterol, a crucial component of fungal cell membranes. Ketoconazole works by blocking the enzyme lanosterol demethylase, which is essential in the conversion of lanosterol to ergosterol. Without sufficient ergosterol, the fungal cell membrane becomes compromised, leading to increased membrane permeability and disruption of essential cellular functions. This disruption inhibits the growth and replication of fungi, ultimately leading to their death.

Antifungal

This medication is used to treat:

• Vaginal candidiasis
• Oral candidiasis
• Cryptococcal meningitis
• Candidemia
• Systemic fungal infections
• Fungal infection prevention

Ketoconazole (lotion) dosage recommendations are:

• Apply a thin layer of the lotion to the affected area of the skin once or twice daily, depending on the severity of the infection and the specific instructions provided by your healthcare provider.

In case of overdose, contact a healthcare professional. Overuse may cause skin irritation or unwanted side effects. Follow medical advice.

If you miss an application, apply the lotion as soon as you remember. If it is close to the next application, skip the missed dose. Do not use extra to make up for a missed application.

Apply a thin layer of lotion to the affected areas of the skin. Gently rub in and allow to dry.

Ketoconazole lotion should not be used in the following situations:

• Allergy to ketoconazole
• Open or irritated skin
• Pregnancy
• Breastfeeding

Unraveling the side effects lurking behind this product are the following:

• Skin irritation
• Allergic reactions
• Dryness
• Burning or stinging sensation

Here are some important precautions and warnings for patients to consider:

• Patients with actual or borderline adrenal insufficiency or those undergoing prolonged periods of physiological stress (e.g. major surgery, intensive care, infection) should exercise caution.
• Individuals with acute porphyria should consult their healthcare provider.
• Administer ketoconazole with an acidic beverage (e.g. cola) to prevent reduced absorption due to high gastric content pH in patients with achlorhydria.
• For systemic fungal infections, ketoconazole tablets should only be used when other effective antifungal therapies are unavailable or intolerable, and when the potential benefits outweigh the risks. It is not indicated for the treatment of cutaneous dermatophyte infections, onychomycosis, or Candida infections.
• Extra care is necessary when administering the medication to children.
• Special considerations are required during pregnancy and lactation (topical use).

Drug interactions with ketoconazole include:

• CYP3A4 substrates (e.g., midazolam, simvastatin) (may increase levels of these drugs- monitor for side effects and adjust doses as necessary)
• CYP3A4 inducers (e.g., rifampin) (may decrease ketoconazole levels- monitor for reduced efficacy)
• Anticoagulants (e.g., warfarin) (may enhance anticoagulant effects- monitor INR closely)
• Benzodiazepines (e.g., diazepam) (may increase benzodiazepine levels- monitor for increased sedation)
• Antiepileptics (e.g., phenytoin) (may decrease ketoconazole levels- monitor for reduced efficacy)
• Antacids (e.g., magnesium hydroxide) (may reduce ketoconazole absorption- take ketoconazole at least 2 hours before antacids)
• H2-receptor antagonists (e.g., ranitidine) (may reduce ketoconazole absorption- monitor for efficacy)
• Methadone (may enhance methadone effects- monitor for side effects)

Ketoconazole should be stored properly to maintain its effectiveness. Store the product at a temperature between 15°C and 30°C in a cool, dry place, away from direct heat, light, and moisture. Ensure the container is tightly closed to prevent contamination. For safety purposes, keep Ketoconazole out of reach of children and pets to avoid accidental ingestion. It is advisable to avoid storing the product in humid or warm areas, such as bathrooms or kitchens. If you have any questions or concerns about proper storage, consult your doctor or pharmacist.