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Lornoxicam, an active component in the tablet, is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins. It achieves this by blocking cyclooxygenase (COX) enzymes, primarily COX-2, which are responsible for the synthesis of prostaglandins involved in pain and inflammation. By reducing prostaglandin levels, lornoxicam effectively diminishes pain, inflammation, and fever. On the other hand, Montelukast, the other active ingredient, is a leukotriene receptor antagonist. It exerts its effects by selectively blocking the cysteinyl leukotriene receptor type 1, thereby inhibiting the actions of leukotrienes, potent inflammatory mediators. This mechanism helps reduce inflammation and relaxes the smooth muscles in the airways, making it beneficial in managing asthma and allergic conditions.

Lornoxicam 8mg, Montelukast 10mg

NSAID, Leukotriene receptor antagonist

Tablet

The following are the uses of Lornoxicam 8mg, Montelukast 10mg Tablet:

• Used for relieving pain and reducing inflammation, particularly in conditions like arthritis.
• Used to treat symptoms of asthma and seasonal allergies, helping to prevent and manage asthma attacks.
• Used for reducing fever and managing pain post-surgery or due to injuries.
• Used for treating joint and muscle pain, providing relief and improved mobility.
• Used in managing chronic inflammatory conditions to reduce swelling and discomfort.
• Used for alleviating symptoms of allergic rhinitis, such as sneezing and runny nose.
• Used to prevent exercise-induced bronchoconstriction, allowing better endurance during physical activities.

In the case of an overdose of Lornoxicam 8mg and Montelukast 10mg tablets, individuals may experience symptoms such as stomach pain, nausea, and vomiting. If a person suspects an overdose, it is recommended to seek medical advice promptly. Treatment may involve managing symptoms and ensuring the individual's vital signs are stable. Prompt medical intervention can help mitigate potential adverse effects and ensure the well-being of the individual.

In the case of a missed dose of Lornoxicam 8mg, it is recommended to take the medication as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. For Montelukast 10mg, if a dose is missed, take it as soon as possible on the same day, but if it's close to the next day's dose, skip the missed dose and continue with your regular daily tablet. It is important not to double the dose to make up for a missed one.

To take Lornoxicam 8mg and Montelukast 10mg tablets, swallow one tablet of each medication as a single dose, with a glass of water, exactly as prescribed by your healthcare provider, typically once a day.

Following are the conditions/situations when Lornoxicam 8mg and Montelukast 10mg Tablet should not be used:

• Allergy Should not be used in patients with a known allergy or hypersensitivity to Lornoxicam, Montelukast, or any other non-steroidal anti-inflammatory drugs (NSAIDs).
• Active Bleeding Not recommended for individuals with active gastrointestinal bleeding or a history of recurrent bleeding.
• Severe Heart or Blood Vessel Diseases Contraindicated in patients with severe cardiovascular diseases such as heart failure, angina, or recent heart attack.
• Severe Liver or Kidney Impairment Should not be used in patients with severe liver or kidney disease as it may worsen the condition.
• Aspirin Allergy Not suitable for individuals with a history of allergy to Aspirin or other NSAIDs, especially those who have experienced asthma attacks, hives, or severe allergic reactions.

The side effects of Lornoxicam 8mg and Montelukast 10mg Tablet may include:

• Abdominal pain
• Diarrhea
• Nausea
• Headache
• Dizziness
• Skin rash or itching
• Increased liver enzymes
• Nasal congestion

Following are the precautions and warnings for Lornoxicam 8mg, Montelukast 10mg Tablet:

• This medication should be used with caution in patients with a history of gastrointestinal problems, as it may cause irritation or bleeding in the stomach or intestines.
• Patients with cardiovascular conditions should be closely monitored, as Lornoxicam can increase the risk of cardiovascular events.
• Not recommended for individuals with a known allergy to Lornoxicam, Montelukast, or related anti-inflammatory drugs.
• Patients with liver disease should exercise caution and undergo regular liver function tests while using this medication.
• Avoid alcohol consumption while taking this medication, as it may increase the risk of gastrointestinal bleeding.
• Elderly patients may be more susceptible to side effects; dosage adjustments might be necessary.
• Should not be used during pregnancy or breastfeeding unless the potential benefits outweigh the risks.
• This medication may cause dizziness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.

Following are the drug interactions for Lornoxicam 8mg, Montelukast 10mg Tablet:

• Lornoxicam may interact with other non-steroidal anti-inflammatory drugs (NSAIDs) and increase the risk of gastrointestinal bleeding and kidney problems.
• Avoid using Lornoxicam with other selective COX-2 inhibitors like celecoxib, as it may reduce the cardiovascular benefits of these medications.
• Montelukast can interact with strong CYP3A4 inducers like rifampin, decreasing its effectiveness.
• The effectiveness of Montelukast may be reduced when used with phenobarbital, a CYP450 inducer.
• Montelukast may interact with warfarin, potentially altering its anticoagulant effect and requiring close monitoring of INR.
• Use with caution in patients taking theophylline, as Montelukast may increase theophylline levels.
• Concomitant use with other leukotriene modifiers is not recommended as it may increase the risk of side effects.

Following are the food interactions for Lornoxicam 8mg and Montelukast 10mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they may influence the metabolism of Lornoxicam, potentially increasing its levels in the blood and altering its effectiveness.
• Alcohol consumption should be minimized or avoided as it can increase the risk of gastrointestinal bleeding when combined with Lornoxicam.
• Fatty meals can slightly decrease the absorption of Montelukast, but this effect is not considered clinically significant.
• Avoid caffeine or limit its intake as it may increase the risk of nervousness and sleep disturbances, especially with Montelukast.
• Foods rich in vitamin K, like leafy greens, should be consumed consistently as Lornoxicam may impact blood clotting.
• Maintain a balanced diet to support overall health and minimize potential drug-induced nutrient depletion.
• No significant food interactions are reported for Montelukast that affect its absorption or metabolism.
• Always consult your healthcare provider for personalized advice on dietary considerations.

Lornoxicam 8mg and Montelukast 10mg tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the tablets in their original packaging, tightly sealed to maintain their integrity. It is crucial not to expose the medication to excessive heat or cold, so avoid storing it near heat sources or in the bathroom. Always adhere to the recommended storage conditions to preserve the effectiveness of the medication. When disposing of unused or expired tablets, do not flush them down the toilet or discard them in household waste. Consult your pharmacist or healthcare professional for guidance on safe and environmentally friendly disposal practices, ensuring that the medication is kept away from children and pets at all times.

Following are the quick tips for Lornoxicam 8mg and Montelukast 10mg Tablets:

• Take the tablet as directed by your doctor, usually once or twice daily.
• Swallow the tablet whole with a full glass of water; do not crush or chew.
• Consume it at the same time each day to maintain a consistent level in your body.
• Lornoxicam should be taken with or after food to prevent stomach irritation.
• Montelukast can be taken with or without food, but should be taken at the same time daily.
• Do not take more than the prescribed dose, and inform your doctor if you have any allergies.
• Store these medications in a cool, dry place, away from direct sunlight and moisture.