40Lac Inj

Benzylpenicillin, also known as penicillin G, and Procaine Penicillin Injection work by inhibiting the synthesis of bacterial cell walls. The active ingredient, benzylpenicillin, belongs to the penicillin class of antibiotics and acts as a bactericidal agent. It specifically targets bacteria by binding to specific proteins called penicillin-binding proteins (PBPs) located on the bacterial cell wall. This binding interferes with the cross-linking of peptidoglycan, a crucial component of the cell wall, which weakens the wall structure and eventually leads to cell lysis and death. The procaine component in Procaine Penicillin Injection provides a local anesthetic effect, allowing for reduced pain during administration, while the penicillin component exerts its antibacterial action by disrupting bacterial cell wall synthesis.

Benzyl Penicillin, Procaine Penicillin

Penicillin Antibiotics

Injection

The following are the uses of Benzyl Penicillin, Procaine Penicillin Injection:

• Used for treating bacterial infections such as pneumonia, meningitis, and syphilis.
• Used for combating infections caused by Streptococcus and Pneumococcus bacteria.
• Used for skin and soft tissue infections, providing rapid relief.
• Used for treating respiratory tract infections, offering effective antibacterial action.
• Used for preventing infection in surgical procedures, ensuring patient safety.
• Used for treating severe dental infections, promoting oral health.
• Used for addressing ear, nose, and throat infections, ensuring comfort and recovery.
• Used for its broad-spectrum activity against various bacteria, making it a versatile antibiotic.

In the case of an overdose of Benzyl Penicillin or Procaine Penicillin Injection, symptoms may include severe allergic reactions, such as anaphylaxis, characterized by difficulty breathing, hives, and swelling. Gastrointestinal issues like nausea, vomiting, and diarrhea can occur. Additionally, an overdose may lead to neurological symptoms, including seizures and confusion. Prompt medical intervention is necessary, and treatment may involve managing symptoms, providing respiratory support, and ensuring the patient's vital signs are stable.

In the case of a missed dose of Benzyl Penicillin or Procaine Penicillin Injection, it is important to administer the missed dose as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. For Benzyl Penicillin, inject the missed dose intramuscularly, and for Procaine Penicillin, follow the prescribed route of administration. Consult your healthcare provider if you frequently miss doses or have concerns about your medication regimen.

To administer the Benzyl Penicillin, Procaine Penicillin Injection, gently swirl the vial to ensure the solution is mixed well, then using a sterile syringe, draw the prescribed dose and inject it intramuscularly, typically into the upper arm, thigh, or buttock, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Benzyl Penicillin, Procaine Penicillin Injection should be avoided:

• Must not be used in patients with a history of severe allergic reactions to penicillin or any other beta-lactam antibiotics.
• Contraindicated in individuals with a known allergy to procaine or any local anesthetics.
• Should not be administered to patients with suspected or confirmed infectious mononucleosis.
• Avoid in patients with a history of epilepsy or other seizure disorders.
• Not recommended for individuals with severe kidney disease or impaired kidney function.
• Should be avoided during breastfeeding as it may pass into breast milk and cause adverse effects in the nursing infant.
• Not suitable for patients with known blood dyscrasias, particularly leukopenia or granulocytopenia.

The side effects of Benzyl Penicillin, Procaine Penicillin Injection may include:

• Allergic reactions, such as skin rash, itching, hives, or difficulty breathing.
• Nausea, vomiting, or diarrhea.
• Pain, swelling, or redness at the injection site.
• Fever or chills.
• Joint or muscle pain.
• Nervousness or anxiety.
• Headache or dizziness.
• Vaginal itching or discharge.

Following are the precautions and warnings for Benzyl Penicillin, Procaine Penicillin Injection:

• Allergic reactions can occur; ensure immediate access to emergency equipment and medications.
• Use with caution in patients with a history of allergies, asthma, or hay fever, as they may be more susceptible to reactions.
• May cause diarrhea, and prolonged use may lead to a new infection; monitor and treat if necessary.
• Ensure the patient is not allergic to penicillin or any other beta-lactam antibiotics before administration.
• May cause neurotoxicity, especially in patients with kidney problems or those receiving high doses; monitor kidney function.
• Not recommended for use in meningitis due to insufficient penetration into the cerebrospinal fluid.
• Use with caution in patients with a history of gastrointestinal diseases as it may exacerbate these conditions.
• Pregnant and breastfeeding women should use it only if clearly needed and under medical supervision.

Following are the drug interactions for Benzyl Penicillin, Procaine Penicillin Injection:

• Allopurinol may reduce the excretion of penicillins, leading to higher plasma concentrations and increased risk of side effects.
• Probenecid can inhibit the renal tubular secretion of penicillin, resulting in elevated and prolonged serum levels.
• The bactericidal effect of penicillin can be antagonized by chloramphenicol.
• The concurrent use of methotrexate and penicillin may decrease the renal clearance of methotrexate, increasing its toxicity.
• May reduce the efficacy of oral contraceptives, potentially reducing their effectiveness in preventing pregnancy.
• Antacids containing aluminum can decrease the absorption of penicillin when taken simultaneously.
• Tetracyclines may reduce the efficacy of penicillin by forming inactive chelates with calcium.

Following are the food interactions for Benzyl Penicillin, Procaine Penicillin Injection:

• Alcohol should be consumed in moderation or avoided as it may reduce the absorption of penicillin, leading to decreased effectiveness.
• Maintain a balanced diet to support overall health and ensure optimal medication effectiveness.
• Grapefruit and grapefruit juice should be avoided as they may interfere with the breakdown of penicillin, potentially increasing the risk of side effects.
• Dairy products like milk, yogurt, and cheese should be consumed separately from penicillin, as calcium can bind to the antibiotic, reducing its absorption.
• Avoid consuming high-fat meals as they may delay the absorption of penicillin.
• Vitamin C supplements or citrus fruits may reduce the effectiveness of penicillin, so timing should be spaced out.
• Always follow the advice of your healthcare provider regarding dietary considerations during penicillin treatment.

Benzyl Penicillin, Procaine Penicillin Injection should be stored in a cool, controlled environment, preferably between 2°C and 8°C (36°F and 46°F), in its original packaging to maintain its potency. Protect it from direct sunlight and moisture, as exposure to light and humidity can degrade the medication. Always check the expiration date before use, and do not use the injection if it has expired. When disposing of unused or expired injections, do not throw them into the regular trash or pour them down the drain. Contact your local waste management authorities or healthcare provider for guidance on safe disposal methods to prevent environmental contamination. Keep the medication out of the reach of children and pets to avoid accidental exposure.

Following are the quick tips for Benzyl Penicillin and Procaine Penicillin Injection:

• Always follow your doctor's prescription for dosage and administration instructions.
• Ensure the injection is administered by a trained healthcare professional.
• Before use, check the expiry date and visually inspect the solution for any discoloration or particulate matter.
• Procaine Penicillin should be injected intramuscularly and slowly to minimize discomfort.
• Inform your doctor if you have any known allergies, especially to penicillin or similar antibiotics.
• Report any side effects, such as severe skin reactions or difficulty breathing, immediately to your healthcare provider.
• Store the injections as directed, usually at room temperature, protected from light.