Abacus (40mg/5ml) 50ml Suspension

Cefpodoxime, the active ingredient in Cefpodoxime 40mg/5ml Syrup/Suspension, is a third-generation cephalosporin antibiotic. It works by inhibiting the synthesis of the bacterial cell wall, specifically targeting the final stage of peptidoglycan synthesis. Cefpodoxime binds to and blocks the activity of penicillin-binding proteins (PBPs), which are essential enzymes responsible for cross-linking the peptidoglycan chains in the bacterial cell wall. By disrupting this process, it weakens the cell wall, leading to cell lysis and ultimately bacterial death. This mechanism of action is selective for bacterial cells as it targets enzymes that are not present in human cells, making it effective against a wide range of bacteria while minimizing adverse effects on the host.

Cefpodoxime 40mg/5ml

Third-generation cephalosporin antibiotic.

Suspension

The following are the uses of Cefpodoxime 40mg/5ml Syrup/Suspension:

• Used for treating bacterial infections such as pneumonia, bronchitis, and sinusitis.
• Used for managing skin and soft tissue infections, including cellulitis and impetigo.
• Used to combat certain types of ear infections (otitis media).
• Effective for treating urinary tract infections caused by susceptible bacteria.
• Used for preventing and treating bacterial complications in patients with chronic obstructive pulmonary disease (COPD).
• Can be used for treating Lyme disease, particularly in its early stages.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Pediatric Patients (aged 3 months to 12 years) - Otitis Media - 7.8 mg/kg of body weight once daily for 7 days
• Pediatric Patients (aged 3 months to 12 years) - Pharyngitis/ Tonsillitis - 11.3 mg/kg of body weight once daily for 7 days
• Pediatric Patients (aged 3 months to 12 years) - Acute maxillary sinusitis - 16.7 mg/kg of body weight once daily for 10 days
• Adult Patients (aged 12 years and older) - Acute bacterial sinusitis - 200 mg once daily for 5-14 days
• Adult Patients (aged 12 years and older) - Community acquired pneumonia - 200 mg once daily for 5-14 days
• Adult Patients (aged 12 years and older) - Skin and skin structure infections - 800 mg once daily for 2-14 days

In the case of an overdose of Cefpodoxime 40mg/5ml Syrup/Suspension, individuals may experience symptoms such as nausea, vomiting, diarrhea, and abdominal pain. The severity of these symptoms can vary depending on the amount ingested. Prompt medical attention is necessary to manage the overdose effectively. Healthcare professionals may induce vomiting or administer activated charcoal to prevent further absorption of the medication. Close monitoring of vital signs and supportive care are essential during treatment.

In the case of a missed dose of Cefpodoxime 40mg/5ml Syrup/Suspension, it is important to administer the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. However, do not double the dose to make up for the missed one. For children, it is crucial to measure the correct dose using a medication syringe or dose cup. Always store the medication at room temperature and keep it out of reach of children.

To administer Cefpodoxime 40mg/5ml Syrup/Suspension, shake the bottle well, measure the prescribed dose with an oral syringe or measuring cup, and give it to your child orally, ensuring it is taken as directed by your healthcare provider, typically twice a day with or without food.

Here are the conditions or situations when Cefpodoxime 40mg/5ml Syrup/Suspension should not be used:

• Do not use if the patient is allergic to cefpodoxime or any other cephalosporin antibiotics.
• Avoid in patients with a history of severe allergic reactions to penicillins, as cross-reactivity may occur.
• Not suitable for patients with a known hypersensitivity to any of the excipients in the syrup/suspension.
• Contraindicated in patients with a history of severe gastrointestinal problems, especially colitis or antibiotic-associated colitis.
• Should not be used in patients with severe renal impairment without adjusting the dose.
• Not recommended for the treatment of viral infections such as the common cold or flu.
• Avoid in patients with a history of seizures or conditions that lower the seizure threshold.

The side effects of Cefpodoxime 40mg/5ml Syrup/Suspension may include:

• Diarrhea
• Nausea and vomiting
• Abdominal pain
• Skin rash or itching
• Headache
• Dizziness
• Vaginal yeast infection (in females)
• Allergic reactions (rare)

Following are the precautions and warnings for Cefpodoxime 40mg/5ml Syrup/Suspension:

• This medication should not be used in patients with a known allergy to Cefpodoxime or any other similar antibiotics, such as cephalosporins.
• Patients with a history of gastrointestinal diseases, particularly colitis, should exercise caution and inform their doctor before taking this medication.
• Cefpodoxime may cause diarrhea, and if it becomes severe or persistent, patients should seek medical attention as it could be a sign of a more serious condition.
• Caution is advised for patients with kidney impairment, as dosage adjustments may be necessary.
• The medication should be taken with a full glass of water to prevent irritation to the throat and stomach.
• Cefpodoxime may cause false-positive results for certain urine glucose tests, so it is important to inform healthcare professionals about the medication use.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as its safety during these periods is not fully established.
• Always complete the full course of medication as prescribed, even if symptoms improve, to ensure the infection is completely treated.

Following are the drug interactions for Cefpodoxime 40mg/5ml Syrup/Suspension:

• Probenecid can decrease the elimination of Cefpodoxime, potentially leading to increased serum levels.
• Nephrotoxic drugs, such as aminoglycosides or diuretics, may increase the risk of kidney-related side effects when used with Cefpodoxime.
• Cefpodoxime may reduce the effectiveness of oral contraceptives, so alternative contraception is recommended during treatment.
• Antacids containing aluminum or magnesium can decrease the absorption of Cefpodoxime if taken simultaneously.
• The effectiveness of Cefpodoxime may be reduced when used with chloramphenicol, as it can inhibit its bacterial killing activity.
• Live attenuated vaccines, such as the measles or oral polio vaccine, may not work as well during and shortly after Cefpodoxime treatment.
• The risk of bleeding may increase when Cefpodoxime is combined with anticoagulants, necessitating close monitoring of coagulation parameters.

Following are the food interactions for Cefpodoxime 40mg/5ml Syrup/Suspension:

• Cefpodoxime should be taken on an empty stomach, at least 1 hour before or 2 hours after meals. Food can decrease the absorption of the medication.
• Avoid consuming alcohol during the treatment period as it may increase the risk of side effects and stomach irritation.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the breakdown of Cefpodoxime, leading to higher levels of the drug in the body.
• Dairy products like milk, cheese, and yogurt may reduce the absorption of Cefpodoxime. Consume them at a different time than the medication.
• Avoid high-fat meals as they may delay the absorption of Cefpodoxime, potentially reducing its effectiveness.
• Caffeine-rich foods and beverages such as coffee, tea, and chocolate should be limited as they may increase stomach acid production and potentially reduce the effectiveness of the medication.
• It is generally recommended to maintain a healthy and balanced diet to support overall health during the course of treatment.

Cefpodoxime 40mg/5ml Syrup/Suspension should be stored in a cool and dry place, preferably at room temperature, ensuring it is protected from direct exposure to sunlight and moisture. Keep the medication securely sealed within its original packaging to maintain its integrity and prevent contamination. It is crucial to avoid storing it in areas prone to temperature fluctuations, such as bathrooms, kitchens, or near heat sources, as this can compromise its effectiveness. Regularly check the expiration date, and when disposing of any unused or expired syrup, do not flush it or pour it down the drain. Contact your pharmacist or healthcare professional for guidance on appropriate disposal methods, and always keep medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Cefpodoxime 40mg/5ml Syrup/Suspension:

• Always follow your doctor's prescription for dosage instructions.
• Administer the syrup/suspension with an accurate measuring device to ensure correct dosage.
• Shake the bottle vigorously before each use to maintain consistency.
• Store the medication in a cool, dry place, away from direct sunlight.
• Do not use if the syrup/suspension has expired or changed color.
• Contact your healthcare provider if you experience any allergic reactions or severe side effects.
• Complete the full course of medication as prescribed, even if you feel better.

Cefpodoxime Proxetil 40mg/5ml is an antibiotic used to treat bacterial infections. While this drug can be prescribed without specific laboratory tests, it is vital to conduct certain investigations to ensure the drug's safety and effectiveness. These lab tests serve to monitor any alterations in the body's normal functioning due to the medication. One of the necessary tests is a Blood Count (CBC), which assesses the body's various blood cells to identify any abnormalities or disorders, such as anemia (low red blood cells) or leukopenia (low white blood cells), that could result from impacting bone marrow production or altering the body's immune response. Renal Function Tests are crucial as Cefpodoxime Proxetil is excreted by the kidneys. Thus, these tests monitor the drug's impact on kidney function, evaluating serum creatinine, blood urea nitrogen (BUN), and glomerular filtration rate (GFR) to ensure the kidneys adequately filter and excrete the drug and its metabolites. Liver Function Tests are necessary as the liver plays a role in metabolizing the drug to produce its active form. These tests, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, and albumin, help ensure the drug does not cause liver damage or impairment. Electrolyte Panels are conducted to ensure the antibiotic does not disrupt the balance of electrolytes in the body, measuring sodium, potassium, calcium, and magnesium levels. Although rare, anaphylactic reactions may be seen in cases of beta-lactam antibiotics. Thus, anaphylactic tests may be required in certain cases to mitigate such risks.