Acabel (8mg/2ml) 1 Ampoule

Lornoxicam, an active component of the 8mg injection, is a non-steroidal anti-inflammatory drug (NSAID) that exerts its analgesic, anti-inflammatory, and antipyretic effects through selective inhibition of cyclooxygenase-2 (COX-2) enzymes. By blocking COX-2, lornoxicam decreases the formation of prostaglandins, which are key mediators of pain, inflammation, and fever. This mechanism effectively reduces pain, lowers elevated body temperature, and alleviates inflammation at the site of injury or disease. The selective inhibition of COX-2 also contributes to a potentially improved gastrointestinal side effect profile compared to non-selective NSAIDs.

Lornoxicam 8mg

Non-steroidal anti-inflammatory drug (NSAID)

injection

The following are the uses of Lornoxicam 8mg injection:

• Used for relieving moderate to severe pain, particularly after surgeries or traumatic injuries.
• Used for reducing inflammation and swelling, making it beneficial for conditions like arthritis.
• Used for managing pain associated with musculoskeletal disorders and acute gout attacks.
• Used for providing rapid relief in postoperative pain management.
• Used for treating acute pain episodes in chronic pain conditions.
• Used for alleviating pain and stiffness in conditions affecting the spine.
• Used for its anti-inflammatory properties to ease discomfort in soft tissue injuries.

Dose to be taken as per doctor's prescription (dependant on the severity of condition, age and weight)

In the case of an overdose of Lornoxicam 8mg injection, it is important to act swiftly. Symptoms may include severe gastrointestinal distress, such as nausea, vomiting, and abdominal pain. Additionally, individuals may experience dizziness, drowsiness, and in extreme cases, seizures. Immediate medical attention is necessary to manage these symptoms, and medical professionals should be informed about the suspected overdose to provide appropriate treatment and support.

In the case of a missed dose of Lornoxicam 8mg injection, it is important to administer the medication as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. However, do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, it is advisable to set reminders or alarms to ensure timely administration. Consult your healthcare provider if you have any concerns or if you miss multiple doses over a short period.

To administer Lornoxicam 8mg injection, clean the injection site, insert the needle at a 90-degree angle, and slowly inject the entire contents of the pre-filled syringe subcutaneously, ensuring proper needle disposal afterward.

Here are the conditions and situations when Lornoxicam 8mg injection should not be used:

• Should not be administered to individuals with a known allergy or hypersensitivity to Lornoxicam or other non-steroidal anti-inflammatory drugs (NSAIDs).
• Contraindicated in patients with active gastrointestinal bleeding or a history of gastrointestinal ulcers or bleeding.
• Not recommended for individuals with severe heart failure or cardiovascular disease.
• Should be avoided in patients with severe kidney or liver impairment.
• Contraindicated during the third trimester of pregnancy as it may cause adverse effects on the fetal cardiovascular system.
• Should not be used in patients with aspirin-sensitive asthma or a history of severe allergic reactions to aspirin or other NSAIDs.
• Not suitable for individuals with bleeding disorders or those taking anticoagulant medications.
• Should be used with caution and avoided if possible in patients with a history of ischemic heart disease or cerebrovascular disease.
• Contraindicated in children and adolescents under 18 years of age.

The side effects of Lornoxicam 8mg injection may include:

• Nausea and vomiting
• Diarrhea
• Stomach pain or indigestion
• Dizziness or vertigo
• Skin rashes or itching
• Increased blood pressure
• Renal impairment
• Allergic reactions

Following are the precautions and warnings for Lornoxicam 8mg Injection:

• Not recommended for individuals with a known hypersensitivity or allergy to Lornoxicam or other NSAIDs.
• Patients with a history of gastrointestinal bleeding, ulcers, or related disorders should exercise caution and consult a healthcare professional before use.
• Lornoxicam may increase the risk of cardiovascular events; patients with known heart conditions should be closely monitored.
• Not suitable for individuals with severe kidney or liver impairment without proper medical supervision.
• Elderly patients may be more susceptible to adverse effects, and dosage adjustments might be necessary.
• It should be used with caution in patients with hypertension, as it may cause fluid retention and elevated blood pressure.
• Pregnant and breastfeeding women should consult their doctor before using this medication, as it may have potential risks for the fetus and infant.

Following are the drug interactions for Lornoxicam 8mg injection:

• Concurrent use with other non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal bleeding and renal toxicity.
• Lornoxicam can reduce the efficacy of antihypertensive medications, including beta-blockers and ACE inhibitors.
• It may increase the risk of bleeding when taken with anticoagulants, such as warfarin or heparin.
• When combined with diuretics, especially loop diuretics, lornoxicam may decrease diuretic efficacy and increase the risk of renal toxicity.
• The concurrent use of Lornoxicam with lithium may result in increased lithium levels and potential lithium toxicity.
• Methotrexate levels can be elevated when used with Lornoxicam, leading to increased risk of methotrexate toxicity.
• Lornoxicam may enhance the anticoagulant effect of antiplatelet drugs like clopidogrel, potentially increasing bleeding risk.

Following are the food interactions for Lornoxicam 8mg injection:

• Avoid excessive alcohol consumption while taking this medication as it may increase the risk of gastrointestinal bleeding and liver toxicity.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of the drug, potentially increasing Lornoxicam levels in the body.
• Fatty foods may slightly delay the absorption of Lornoxicam, but this is generally not clinically significant.
• There is no specific food restriction, but maintaining a balanced diet is advisable to support overall health and medication effectiveness.
• Avoid spicy foods as they can irritate the stomach and potentially worsen gastrointestinal side effects associated with Lornoxicam.
• Ensure adequate fluid intake to reduce the risk of kidney-related issues, especially if Lornoxicam is used for prolonged periods.
• Consult your healthcare provider if you have specific dietary concerns or restrictions to ensure safe and effective use of Lornoxicam.
• Avoid herbal supplements or natural remedies without medical advice as some may interact with Lornoxicam's metabolism.

Lornoxicam 8mg injection should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 15°C and 25°C (59°F and 77°F). Protect the injection from direct sunlight, heat, and moisture to maintain its stability and potency. Always keep the medication in its original packaging, ensuring the seal is intact, to prevent contamination. Prioritize the disposal of any unused or expired injections according to local regulations and guidelines. Do not dispose of them in household trash or pour them down the drain; instead, contact your healthcare provider or pharmacist for appropriate disposal options. Remember to keep the medication away from children and pets to prevent accidental exposure or ingestion.

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Following are the quick tips for Lornoxicam 8mg Injection:

• Ensure the injection is administered by a trained medical professional.
• Verify the correct dosage and injection site as prescribed.
• The injection is typically given into a muscle or vein, as directed.
• Before injecting, clean the injection site with an antiseptic.
• Do not use if the solution appears discolored or contains particles.
• After injection, apply gentle pressure with a sterile pad to prevent bleeding.
• Seek immediate medical attention if any adverse reactions occur.