ACETAX 25

Acitretin, the active component in Acetretin 25mg Tablets, is a retinoid primarily used for its effects on skin cells. Its mechanism of action involves binding to specific nuclear receptors called retinoic acid receptors (RARs) and retinoid X receptors (RXRs). By activating these receptors, acitretin modulates gene expression, influencing cellular differentiation, proliferation, and apoptosis, particularly in keratinocytes and other skin cells. This action helps regulate epidermal cell growth and differentiation, reducing the symptoms associated with various skin conditions. Acitretin's impact on gene expression also contributes to its effectiveness in managing these skin disorders by promoting healthy skin turnover and reducing inflammation.

Acetretin 25mg

Retinoid

Tablet

The following are the uses of Acetretin 25mg Tablet:

• Used for treating severe cystic acne when other treatments have not been successful.
• Used for managing severe psoriasis, a skin condition with red, scaly patches.
• Used to alleviate symptoms of a rare skin condition called pityriasis rubra pilaris.
• Effective for treating a skin disorder called lichen planus, helping reduce inflammation.
• Used in the treatment of Darier's disease, improving skin texture and appearance.
• Helps in managing the symptoms of a skin condition called granuloma annulare.
• Used to treat alopecia areata, a condition causing hair loss, promoting hair regrowth.

In the case of an overdose of Acetretin 25mg Tablets, several symptoms may occur. These include increased severity of side effects such as skin peeling, dry mouth, and changes in vision. More serious effects might involve the central nervous system, leading to headaches, dizziness, and in severe cases, seizures. It is imperative to seek medical advice if an overdose is suspected, as prompt intervention can mitigate potential health risks associated with excessive Acetretin consumption.

In the case of a missed dose of Acetretin 25mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for advice on how to safely adjust your dosing schedule. It is recommended to set reminders or use a pill organizer to help you remember to take your medication at the correct time.

To take Acetretin 25mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions when Acetretin 25mg Tablet should not be used:

• Should not be taken if you have a known allergy to Acetretin or any of its ingredients.
• Contraindicated in women who are pregnant or planning to become pregnant.
• Avoid if you are breastfeeding, as the drug may pass into breast milk.
• Not suitable for individuals with severe liver or kidney impairment.
• Should not be used if you have uncontrolled high cholesterol or triglyceride levels.
• Avoid if you have a vitamin A sensitivity or have recently taken other vitamin A-related medications.
• Contraindicated in children and adolescents, as it can interfere with bone development.

The side effects of Acetretin 25mg Tablet may include:

• Dry skin
• Itching or rash
• Hair loss
• Joint and muscle pain
• Headache
• Increased liver enzymes
• Lip inflammation
• Changes in nail growth

Following are the precautions and warnings for Acetretin 25mg Tablet:

• This medication is contraindicated in patients who are pregnant or planning to become pregnant. It can cause severe birth defects, and pregnancy should be avoided during treatment and for at least 3 years after discontinuation.
• Women of childbearing potential must use two reliable forms of contraception simultaneously while on Acetretin and for at least 3 years after stopping the medication.
• Do not donate blood while taking Acetretin and for at least 3 years after stopping, as this could lead to exposure in pregnant women.
• Acetretin may increase the risk of bone fractures; regular monitoring of bone mineral density is recommended, especially in long-term use.
• It may cause liver damage; liver function tests should be performed before and during treatment.
• Avoid excessive exposure to sunlight and UV rays; use protective measures as the drug increases sensitivity to sunlight.
• Inform your doctor about all medications you are taking, including vitamins and herbal supplements, to avoid potential drug interactions.
• Keep this medication out of the reach of children and pets; accidental ingestion can be harmful.

Following are the drug interactions for Acetretin 25mg Tablet:

• Tetracyclines should be avoided during and for at least 3 months after retinoid therapy due to increased intracranial pressure.
• Concomitant use with vitamin A or other retinoids may lead to hypervitaminosis A, causing symptoms like headache, nausea, and skin changes.
• It may decrease the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• The risk of hepatotoxicity is increased when combined with methotrexate, requiring close monitoring.
• Isotretinoin and other hepatotoxic drugs can elevate liver enzymes, so caution is necessary when combined.
• Avoid alcohol consumption as it may increase the risk of hepatotoxicity and other adverse effects.
• Some herbal supplements, like St. John's Wort, can decrease Acetretin's effectiveness and increase photosensitivity.

Following are the food interactions for Acetretin 25mg Tablet:

• Avoid Vitamin A-rich foods like liver, fish liver oils, and supplements containing Vitamin A, as excessive Vitamin A can lead to toxicity when combined with Acetretin.
• Dairy products with high-fat content, such as whole milk, cream, and cheese, should be limited as they may increase the absorption of the drug and alter its effectiveness.
• Grapefruit and grapefruit juice are to be avoided as they can inhibit the metabolism of Acetretin, leading to increased blood levels and potential side effects.
• Alcohol consumption should be minimized or avoided as it may increase the risk of liver toxicity and other side effects when combined with Acetretin.
• Foods rich in Omega-3 fatty acids, such as salmon, sardines, and flaxseeds, might increase the risk of bleeding when taken with Acetretin, especially in high doses.
• Limit the intake of green leafy vegetables like spinach and kale, as these are high in Vitamin K, which can counteract the blood-thinning effects of Acetretin.
• Avoid excessive consumption of foods rich in Vitamin E, such as nuts and seeds, as this vitamin can also interact with Acetretin and affect its anticoagulant properties.
• Always consult your healthcare provider for personalized advice regarding specific dietary restrictions and interactions while taking Acetretin.

Acetretin 25mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, ensuring they are out of reach of children and pets. Maintain a consistent room temperature, avoiding excessive heat or cold, as temperature fluctuations can impact the medication's effectiveness. Protect the tablets from direct sunlight, moisture, and humidity, as these factors can cause degradation. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Regularly check the expiration date, and dispose of any unused or expired tablets promptly. Proper disposal is crucial; do not flush them down the toilet or discard them in household waste. Contact your pharmacist or local waste management authority for guidance on safe disposal methods to minimize environmental impact.

Following are the quick tips for Acetretin 25mg Tablet:

• Consult your doctor before taking this medication, especially if you have any liver or kidney issues.
• Take the tablet as directed by your doctor; do not change the dosage without medical advice.
• Ensure you complete the full course of medication as prescribed.
• Avoid consuming alcohol while taking this medicine as it may increase the risk of side effects.
• Inform your doctor about all medications you are currently taking to prevent potential drug interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Do not share this medication with others; it is prescribed specifically for your condition.