Acetin (25mg) 30 Capsules

Acitretin is a retinoid medication primarily used for its effects on skin cells. Its mechanism of action involves binding to cellular retinoic acid receptors (RARs), which are nuclear receptors that regulate gene expression. By activating RARs, acitretin influences the transcription of genes involved in cellular differentiation, proliferation, and inflammation. This action helps normalize the growth and maturation of skin cells, particularly keratinocytes, reducing the excessive skin cell turnover seen in conditions like psoriasis. Additionally, acitretin can modulate the production of pro-inflammatory mediators, such as cytokines, thereby reducing inflammation in the skin. This dual action of promoting skin cell differentiation and suppressing inflammation contributes to its effectiveness in managing various skin disorders.

Acitretin 25mg

Retinoid derivative.

Capsule

The following are the uses of Acitretin 25mg Capsule:

• Used for treating severe psoriasis, providing relief from itchy and scaly skin.
• Used to manage pustular psoriasis, an uncommon form of the condition.
• Effective in treating severe acne that has not responded to other treatments.
• Helps clear up skin lesions and reduces the severity of symptoms.
• Can be used in combination with other therapies for enhanced results.
• Aids in slowing down the rapid growth of skin cells, promoting healthier skin.
• May be prescribed to improve nail psoriasis, leading to clearer nails.
• Provides a systemic approach to managing skin conditions, offering comprehensive relief.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For acute pityriasis lichenoides, a dosage of 25mg daily for a period of 4-6 months is typically recommended.
• For psoriasis, Acitretin is usually dosed at 0.5-1mg/kg/day, and it's recommended to start at a lower dose of 25mg daily and increase gradually every week or every other week by 25mg or 37.5mg depending on the response and tolerance to the drug.
• For severe psoriasis unresponsive to milder therapies, Acitretin can be prescribed at a dose of 50mg daily.
• Acitretin is associated with increased risk of birth defects, therefore, it is important to avoid pregnancy while taking this drug, and for at least 3 years after stopping Acitretin.
• It is important to follow the dosing instructions provided by your physician specifically tailored to you.
• If you are experiencing any side effects, discomfort, or unexpected symptoms, notify your physician immediately.

In the case of an overdose of Acitretin 25mg Capsules, it is important to recognize the potential severity of this situation. Initial symptoms may include nausea, vomiting, and dizziness, but more serious complications can arise. Immediate medical intervention is necessary to manage the overdose effectively. Treatment may involve gastric lavage, supportive care, and close monitoring of vital signs and organ function. Prompt action can help mitigate the risks associated with this medication overdose.

In the case of a missed dose of Acitretin 25mg Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take Acitretin 25mg Capsule, swallow the capsule whole with a full glass of water, preferably at the same time each day, following the exact dosage instructions provided by your healthcare professional, without crushing, chewing, or breaking the capsule.

Here are the situations when Acitretin 25mg Capsule should not be used:

• Should not be taken during pregnancy as it may cause severe birth defects.
• Contraindicated in women who are breastfeeding as it can pass into breast milk and harm the baby.
• Not recommended for individuals with severe liver or kidney disease.
• Should not be used by people who are allergic to Acitretin or any similar medications.
• Avoid in patients with uncontrolled cholesterol or triglyceride levels.
• Do not use if you have severe diabetes or uncontrolled blood sugar levels.
• Contraindicated in individuals with severe protein deficiency or malnutrition.
• Not suitable for people with severe depression or suicidal thoughts.
• Should not be used in children and adolescents under 18 years of age.

The side effects of Acitretin 25mg Capsule may include:

• Dry skin, itching, and skin peeling
• Dry mouth and lips
• Hair loss or thinning
• Brittle nails
• Joint and muscle pain
• Increased sensitivity to sunlight
• Changes in blood lipid levels (increased cholesterol and triglycerides)
• Elevated liver enzymes

Following are the precautions and warnings for Acitretin 25mg Capsule:

• Not recommended for women who are pregnant or planning to become pregnant, as it can cause severe birth defects.
• Breastfeeding mothers should not use this medication as it may pass into breast milk and harm the baby.
• Avoid excessive exposure to sunlight and UV rays, and use sunscreen and protective clothing during treatment.
• Blood tests are required to monitor liver function and lipid levels regularly while on this medication.
• Patients with liver disease or elevated lipid levels should exercise caution and inform their doctor.
• May cause temporary vision issues; avoid activities like driving or operating machinery if affected.
• Not suitable for individuals with severe kidney disease or those undergoing dialysis.
• Discontinue use and seek medical attention if severe skin reactions or persistent headaches occur.

Following are the drug interactions for Acitretin 25mg Capsule:

• Concomitant use with other retinoids or vitamin A supplements can lead to increased risk of side effects due to additive effects.
• Tetracycline antibiotics should be avoided during treatment as they may increase acitretin levels, leading to toxicity.
• Acitretin may decrease the effectiveness of oral contraceptives, requiring alternative contraceptive methods.
• The use of alcohol is not recommended as it can increase the risk of liver toxicity.
• Avoid concurrent use with methotrexate as it may increase the risk of liver and bone marrow toxicity.
• Barbiturates and phenytoin can reduce acitretin levels, potentially decreasing its effectiveness.
• Caution is advised with lipid-lowering agents, as acitretin may cause lipid abnormalities.

Following are the food interactions for Acitretin 25mg Capsule:

• Avoid consuming alcohol as it can increase the risk of liver damage and may also reduce the effectiveness of the medication.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Acitretin, leading to increased drug levels in the body and potential toxicity.
• High-fat meals can delay the absorption of Acitretin, so it is recommended to take the medication on an empty stomach or with a low-fat meal.
• Vitamin A rich foods like liver, fish liver oil, and supplements should be avoided as Acitretin can increase vitamin A levels in the body, potentially causing vitamin A toxicity.
• Dairy products may decrease the absorption of Acitretin, so it is advisable to separate the medication and dairy intake by a few hours.
• Avoid excessive sun exposure and UV light, including tanning beds, as Acitretin can increase sensitivity to sunlight, leading to severe sunburns.
• Avoid Vitamin K rich foods like spinach, kale, and broccoli, as Acitretin can interfere with blood clotting and these foods may affect blood clotting processes.
• Always consult your doctor or pharmacist for specific dietary recommendations and restrictions while taking Acitretin.

Acitretin 25mg Capsules should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight, moisture, and heat. It is crucial to keep the capsules in their original packaging or a tightly sealed container to maintain their integrity and effectiveness. Ensure the storage area is out of reach of children and pets to prevent accidental consumption. When disposing of unused or expired capsules, do not throw them in the trash or flush them down the toilet. Instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for safe disposal methods. Proper disposal helps protect the environment and prevents accidental exposure to the medication. Always handle Acitretin capsules with care, and keep them stored securely to maintain their quality and safety.

Following are the quick tips for Acitretin 25mg Capsule:

• Take the capsule as directed by your doctor, usually once daily with or after a meal.
• Ensure you swallow the capsule whole without crushing or chewing it.
• Maintain a consistent daily routine for taking the medication.
• If you experience dry mouth, drink plenty of water and chew sugar-free gum.
• Avoid excessive sun exposure and use sunscreen when outdoors.
• Do not donate blood while taking this medication and for at least 3 years after stopping.
• Store the capsules in their original container at room temperature, away from moisture and light.

Acitretin is a medication that is commonly used to treat skin conditions such as psoriasis and acne. While it is important to ensure this medication is not causing harmful effects on the body, it is important to get laboratory tests done during your treatment. Laboratory tests will monitor your complete blood count, liver function, and lipid levels to ensure your body is processing the acitretin effectively and safely. These tests are also important in detecting any potential risks or adverse effects that may occur. It is essential to consult with a healthcare professional who can advise on specific tests required and how often they should be conducted.