Acort (0.1/1%) 10g Cream

The mechanism of action of Isoconazole and Diflucortolone Cream involves a combination of antifungal and anti-inflammatory effects. Isoconazole, belonging to the imidazole class of antifungals, exerts its action by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes. This disruption weakens the membrane structure, leading to impaired fungal cell function and eventual cell death. Diflucortolone, a synthetic corticosteroid, provides the anti-inflammatory effect by binding to corticosteroid receptors within cells, resulting in the downregulation of pro-inflammatory genes. This reduces inflammation, redness, and itching associated with various skin conditions. The combination of these two active ingredients in the cream effectively targets both the fungal infection and the associated inflammatory response, making it useful in treating dermatological conditions where both factors are present.

Isoconazole, Diflucortolone

Antifungal, Corticosteroid.

Cream

The following are the uses of Isoconazole, Diflucortolone Cream:

• Used for treating fungal skin infections, especially those accompanied by inflammation and itching.
• Used to alleviate symptoms of skin conditions like eczema, psoriasis, and dermatitis.
• Effective in reducing redness, swelling, and discomfort associated with skin issues.
• Helps manage skin conditions that do not respond to other treatments.
• Provides relief from itching and irritation, promoting skin healing.
• Used for localized skin infections, offering targeted treatment.

In the case of an overdose of Isoconazole and Diflucortolone Cream, it is important to recognize the potential symptoms and take appropriate action. The severity of the overdose can vary, but common signs may include skin irritation, redness, or a burning sensation at the application site. If ingestion occurs, nausea, vomiting, or gastrointestinal discomfort might be experienced. It is advisable to contact a healthcare professional or a poison control center for guidance and to determine the best course of action.

In the case of a missed dose of Isoconazole and Diflucortolone Cream, it is important to apply the medication as soon as you remember. If it's almost time for your next scheduled dose, skip the missed one and continue with your regular application schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. It is best to maintain a consistent application routine, but if you have any concerns or frequently miss doses, consult your healthcare provider for guidance on managing your treatment effectively.

To apply Isoconazole, Diflucortolone Cream, clean and dry the affected area, then gently apply a thin layer of the cream to the skin, usually twice a day or as directed by your healthcare provider, ensuring not to bandage or wrap the treated area tightly.

Following are the conditions or situations when Isoconazole, Diflucortolone Cream should not be used:

• Do not use if you have a known allergy or hypersensitivity to Isoconazole, Diflucortolone or any other related antifungal or steroid medications.
• Avoid using the cream if you have a skin infection caused by viruses, such as herpes or chickenpox.
• Isoconazole, Diflucortolone Cream is not recommended for use in individuals with certain skin conditions like rosacea, acne, or perioral dermatitis.
• Do not use the cream on skin that is broken, severely damaged, or has open wounds.
• Avoid using the cream on areas of skin affected by tuberculosis or syphilis.
• It should not be used in individuals with widespread fungal infections or those who have had a recent vaccination.
• Do not use this cream for longer than the recommended duration without medical supervision.

The side effects of Isoconazole, Diflucortolone Cream may include:

• Skin irritation or burning at the application site
• Itching or redness
• Dry skin
• Thinning of the skin
• Stretch marks
• Allergic reactions (such as rash, hives, swelling)
• Increased hair growth in the treated area
• Skin discoloration

Following are the precautions and warnings for Isoconazole, Diflucortolone Cream:

• Avoid using this cream if you are allergic to any of its ingredients, including isoconazole or diflucortolone.
• Do not apply the cream near eyes, mouth, or open wounds as it is intended for external use only.
• Wash your hands before and after application to avoid accidental contact with sensitive areas.
• If you are pregnant or breastfeeding, consult your doctor before using this medication.
• Prolonged use should be avoided; if symptoms persist or worsen, seek medical advice.
• Do not cover the treated area with airtight dressings or bandages, allow the area to breathe.
• Keep this medication out of reach of children and pets.
• Inform your doctor about any other medications you are taking to prevent potential drug interactions.

Following are the drug interactions for Isoconazole, Diflucortolone Cream:

• The combination of Isoconazole and Diflucortolone may increase the risk of skin atrophy, especially with prolonged use.
• Avoid using other topical corticosteroids or antifungal agents at the same time, as it may lead to additive effects and increased skin irritation.
• Isoconazole can enhance the absorption of other drugs applied to the same area, potentially increasing their systemic effects.
• Diflucortolone may interact with oral corticosteroids, increasing the risk of adrenal suppression.
• Concomitant use with immunosuppressants can further weaken the immune system.
• Topical antibiotics applied simultaneously might reduce the effectiveness of both medications.
• The cream may delay wound healing when used with certain wound dressing materials.

Following are the food interactions for Isoconazole, Diflucortolone Cream:

• Avoid consuming grapefruit and grapefruit juice as these can interfere with the metabolism of the drug, potentially leading to increased drug levels in the body.
• Alcohol consumption should be minimized or avoided as it may enhance the absorption of isoconazole, leading to increased drug levels and potential side effects.
• Caffeine-rich foods and beverages like coffee, tea, and energy drinks may increase alertness and counteract the sedative effects of diflucortolone, which could impact the desired therapeutic effect.
• Fatty foods can potentially affect the absorption of isoconazole, possibly leading to reduced drug absorption and efficacy.
• Spicy foods might cause skin irritation or sensitivity, especially in the area where the cream is applied, due to the presence of capsaicin in spices.
• Foods high in sugar content could potentially impact the skin's healing process, as high blood sugar levels may impair wound healing.
• Avoid vitamin-rich foods like leafy greens, citrus fruits, and berries, as certain vitamins can influence skin health and potentially interact with the topical medication.
• Dairy products, if consumed in large amounts, may affect calcium levels in the body, which could have implications for skin health and medication absorption.

The proper storage and disposal of Isoconazole, Diflucortolone Cream are essential to maintain its effectiveness and prevent misuse. Store the cream in a cool, dry place, preferably at room temperature, ensuring it is kept away from direct sunlight, heat, and moisture. Keep the cream in its original packaging, tightly sealed, to maintain its integrity and protect it from contamination. Regularly check the expiration date, and do not use the cream beyond this date. When disposing of the cream, do not flush it down the toilet or pour it into drainage systems. Instead, consult a pharmacist or healthcare professional for guidance on appropriate disposal methods to minimize environmental impact. Keep the medication out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Isoconazole, Diflucortolone Cream:

• Clean and dry the affected area before applying the cream.
• Apply a thin layer of the cream to the affected skin, gently rubbing it in.
• Wash your hands after application to avoid accidental contact with other body parts.
• Avoid applying the cream near the eyes, mouth, or open wounds.
• Do not cover the treated area with bandages or tight clothing.
• Complete the full course of treatment, even if symptoms improve, to ensure maximum effectiveness.
• Store the cream at room temperature, away from direct sunlight and moisture.