ACRIFLAVINE 50ML (OVAL)

Acriflavine, the active component in ACRIFLAVINE Liquid, primarily exerts its effects through multiple mechanisms of action. It intercalates into DNA, leading to DNA damage and interference with vital cellular processes. This DNA intercalation disrupts DNA replication and transcription, hindering bacterial growth and proliferation. Moreover, acriflavine exhibits the ability to bind to bacterial proteins, particularly DNA gyrase, thereby inhibiting its enzymatic activity. This binding disrupts DNA supercoiling, which is essential for bacterial DNA replication and transcription, further contributing to the antibacterial effect. Additionally, acriflavine can generate reactive oxygen species (ROS), inducing oxidative stress within bacterial cells, which can lead to cellular damage and death. These multifaceted actions contribute to the overall antimicrobial activity of ACRIFLAVINE Liquid.

ACRIFLAVINE

Aminopropyl-diamino-acridine derivative

Liquid

The following are the uses of ACRIFLAVINE Liquid:

• Used for treating external bacterial and fungal infections in fish, such as fin rot, tail rot, and ulcers.
• Used for controlling bacterial and fungal outbreaks in ponds, aquariums, and fish hatcheries.
• Used for promoting healing and preventing secondary infections in fish wounds.
• Used for improving water quality by controlling pathogenic bacteria and fungi.
• Used for maintaining healthy gills and skin in fish, preventing infections.
• Used for treating eggs to prevent fungal and bacterial contamination during hatching.
• Used for creating a protective barrier against pathogens in aquatic environments.

In the case of an overdose of ACRIFLAVINE Liquid, seek emergency medical assistance immediately. Symptoms of overdose may include severe nausea, vomiting, abdominal pain, and potential damage to the digestive tract. Prompt action is vital, as an overdose can lead to serious health complications. Call your local poison control center or emergency services for guidance and to arrange for medical care as soon as possible.

In the case of a missed dose of ACRIFLAVINE Liquid, it is important to administer the medication as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one. If you have missed multiple doses, contact your healthcare provider for guidance on how to safely resume the medication and ensure its effectiveness. Always keep a consistent dosing routine to maximize the benefits of the medication.

To use ACRIFLAVINE Liquid, dilute the prescribed amount in water and apply it directly to the affected skin areas using a clean cloth or cotton pad, ensuring thorough coverage and avoiding contact with eyes and mucous membranes.

Following are the conditions or situations when ACRIFLAVINE Liquid should be avoided:

• Must not be used if you have a known allergy or hypersensitivity to acriflavine or any of the excipients in the liquid formulation.
• Contraindicated in individuals with a history of severe skin reactions or photosensitivity to acriflavine or similar compounds.
• Should not be ingested orally and is only for external use on the skin or mucous membranes.
• Avoid using near the eyes, ears, nose, or other sensitive areas unless directed by a healthcare professional.
• Do not use if the solution is discolored, cloudy, or contains visible particles.
• Not recommended for individuals with extensive skin damage or large open wounds.

The side effects of ACRIFLAVINE Liquid may include:

• Skin irritation and redness at the application site
• Allergic reactions, such as rash, itching, or hives
• Temporary staining of the skin or treated area
• Eye irritation if exposed, resulting in redness or discomfort
• Nausea and dizziness, especially if ingested
• Skin sensitivity to sunlight (photosensitivity)
• In rare cases, severe allergic reactions like difficulty breathing or swelling of the face

Following are the precautions and warnings for ACRIFLAVINE Liquid:

• Avoid contact with eyes and mucous membranes. In case of accidental contact, immediately flush with water.
• Do not ingest or swallow the liquid. It is for external use only.
• Keep out of reach of children and pets. Store in a secure location.
• If you have a known allergy to acriflavine or similar compounds, do not use this product.
• Do not use on open wounds, deep cuts, or serious burns without medical supervision.
• Discontinue use if irritation, redness, or any adverse reaction occurs, and consult a healthcare professional.
• Acriflavine may cause staining of skin and fabrics; exercise caution during application.

Following are the drug interactions for ACRIFLAVINE Liquid:

• Concomitant use with sulfonamides can lead to increased risk of adverse effects, including bone marrow suppression and skin reactions.
• The absorption of Acriflavine may be reduced when taken with kaolin-pectin.
• Antacids containing aluminum may decrease the absorption of Acriflavine, leading to reduced effectiveness.
• May interact with other photosensitizing medications, increasing the risk of sunburn and skin reactions.
• Use with caution when taking diuretics, as Acriflavine can cause electrolyte imbalances.
• Acriflavine may enhance the effects of anticoagulants, requiring close monitoring for bleeding risks.
• The efficacy of live attenuated vaccines may be reduced due to Acriflavine's antimicrobial properties.

Following are the food interactions to consider with Acriflavine Liquid:

• Avoid consuming alcohol during treatment with Acriflavine as it may increase the risk of side effects and impair your ability to concentrate and react.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of many medications, including Acriflavine, potentially leading to increased drug levels in the body.
• Caffeine-rich foods and beverages, such as coffee, tea, and energy drinks, should be limited as they may enhance the stimulant effects of Acriflavine and increase the risk of side effects like restlessness and insomnia.
• Dairy products, especially milk, may reduce the absorption of Acriflavine. Consider taking the medication at least 2 hours before or after consuming milk to maintain its effectiveness.
• High-fat meals may delay the absorption of Acriflavine, potentially affecting its onset of action. Take the medication on an empty stomach or as directed by your healthcare professional.
• Avoid eating Seville oranges and their products (juice, marmalade) as they contain compounds that can interact with Acriflavine, affecting its metabolism.
• If you have a diet rich in cruciferous vegetables (e.g., broccoli, Brussels sprouts, cabbage), consult your doctor as these vegetables may influence the way your body processes Acriflavine.
• Certain spices, such as turmeric and St. John's Wort, may have interactions with Acriflavine. Discuss your dietary habits with your healthcare provider to ensure safe medication use.

Acriflavine Liquid should be stored with utmost care, ensuring it is kept in a secure location, away from direct sunlight, heat, and moisture. Store it in a cool, dry area, preferably in its original container, tightly sealed to maintain its integrity and prevent contamination. Always check the expiration date, and dispose of any outdated or unused liquid responsibly, avoiding disposal through sinks or toilets. It is crucial to keep this liquid out of children's reach to prevent accidental exposure. Proper disposal methods may include returning it to a pharmacist or healthcare facility for safe handling, ensuring environmental and personal safety. Responsible storage and disposal practices are essential for the safe management of Acriflavine Liquid.

Following are the quick tips for ACRIFLAVINE Liquid:

• Ensure the liquid is well-mixed by gently shaking the bottle before each use.
• Measure the dose accurately using the provided measuring device.
• Administer the liquid directly into the mouth, avoiding contact with skin or clothing.
• Rinse your mouth thoroughly with water after taking the medication.
• Do not mix the liquid with other medications or substances without medical advice.
• Store the bottle tightly closed in a cool, dry place, away from direct sunlight.
• Regularly monitor the expiration date and discard any unused medication accordingly.
• Consult your healthcare professional if you have any concerns or experience side effects.