ACTIFED-P COLD ELX

Paracetamol, also known as acetaminophen, works by inhibiting the synthesis of prostaglandins in the central nervous system, which reduces fever and relieves pain. It primarily acts in the hypothalamus to reset the thermoregulatory center, leading to a reduction in body temperature. Triprolidine, on the other hand, is an antihistamine that blocks H1-receptors, thereby preventing the effects of histamine. This action helps to alleviate symptoms such as sneezing, itching, and runny nose by reducing the sensitivity of the nasal passages and respiratory system to allergens.

Analgesic and Antihistamine

Suspension

The following are the uses of Paracetamol 300mg, Triprolidine 1.5mg Syrup/Suspension:

• Used for relieving mild to moderate pain, such as headaches, toothaches, and post-vaccination pain.
• Used to reduce fever and manage discomfort associated with colds and flu.
• Used to alleviate symptoms of allergies, including sneezing, runny nose, and itchy, watery eyes.
• Effective in treating mild to moderate pain caused by injuries or minor surgeries.
• Can be used to manage pain and discomfort during teething in infants and toddlers.
• Helps provide temporary relief from minor aches and pains associated with arthritis.
• Useful for reducing menstrual cramps and mild to moderate pain during menstruation.
• May be prescribed to manage pain and discomfort in certain medical procedures or post-operative care.

In the case of an overdose of Paracetamol 300mg and Triprolidine 1.5mg Syrup/Suspension, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and in severe cases, liver damage. The severity of the effects depends on the amount ingested and individual factors. Prompt medical assessment is necessary, and treatment may involve supportive care and, in some instances, specific antidotes to manage the symptoms and prevent potential complications.

In the case of a missed dose of Paracetamol 300mg, Triprolidine 1.5mg Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It's important to resume your regular dosing schedule and ensure you take the medication as prescribed by your healthcare professional.

To administer Paracetamol 300mg and Triprolidine 1.5mg syrup/suspension, shake the bottle well, and then use the provided measuring device, such as a marked measuring cup or oral syringe, to ensure an accurate dose, which should be taken as directed by your healthcare provider, typically once or twice daily, and can be taken with or without food.

Following are the conditions/situations when Paracetamol 300mg and Triprolidine 1.5mg Syrup/Suspension should not be taken:

• Not suitable for individuals with known allergies to paracetamol, triprolidine, or any other ingredients in the medication.
• Contraindicated in patients with severe liver or kidney disease.
• Avoid using in patients with severe respiratory conditions or breathing difficulties.
• Should not be administered to infants or children under 2 years of age without medical advice.
• Not recommended for individuals with a history of seizures or epilepsy.
• Do not use if you have a history of gastrointestinal obstruction or severe constipation.
• Avoid using this medication if you have narrow-angle glaucoma.
• Do not take this medication if you are currently using monoamine oxidase inhibitors (MAOIs) or have used them within the last 14 days.

The side effects of Paracetamol 300mg and Triprolidine 1.5mg Syrup/Suspension may include:

• Drowsiness or sedation
• Dry mouth
• Constipation
• Nausea and vomiting
• Allergic reactions (skin rash, itching)
• Dizziness or lightheadedness
• Confusion, especially in elderly individuals
• Difficulty urinating (urinary retention)

Following are the precautions and warnings for Paracetamol 300mg, Triprolidine 1.5mg Syrup/Suspension:

• Do not exceed the recommended dosage, as Paracetamol overdose can cause severe liver damage.
• This medication should be used with caution in patients with liver or kidney disease, and regular monitoring is advised.
• Avoid alcohol consumption while taking this medication, as it may increase the risk of liver damage.
• Triprolidine can cause drowsiness and dizziness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Not recommended for use in children under 2 years old without medical supervision.
• Consult a doctor if symptoms persist or worsen after 3-5 days of treatment.
• Pregnant and breastfeeding women should seek medical advice before using this medication.
• Inform your healthcare provider about any other medications you are taking to avoid potential drug interactions.

Following are the drug interactions for Paracetamol 300mg, Triprolidine 1.5mg Syrup/Suspension:

• Avoid alcohol consumption as it may increase drowsiness and impair thinking and motor skills.
• Paracetamol may interact with anticoagulants (blood thinners), such as warfarin, potentially altering its effectiveness.
• It can affect the metabolism of certain medications, including some anticonvulsants and antipsychotics, leading to increased side effects.
• Consuming other cold and flu medications containing paracetamol/acetaminophen or similar ingredients may cause an overdose.
• Triprolidine may enhance the sedative effects of central nervous system depressants like benzodiazepines, opioids, and alcohol.
• MAO inhibitors may interact with triprolidine, potentially leading to increased side effects and serious reactions.
• Caution is advised when using with medications that affect liver function, as it can impact the metabolism of paracetamol.

Following are the food interactions for Paracetamol 300mg, Triprolidine 1.5mg Syrup/Suspension:

• Alcohol consumption should be avoided as it may increase the sedative effects of Triprolidine, leading to enhanced drowsiness and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit the liver enzymes responsible for metabolizing Paracetamol, potentially leading to higher drug levels in the body.
• Avoid caffeine-rich foods and beverages as they may interact with Triprolidine, causing increased heart rate and anxiety.
• Dairy products may affect the absorption of Paracetamol, so it is recommended to take the medication 1-2 hours before or after consuming milk or dairy.
• Fatty foods can delay the absorption of Paracetamol, potentially affecting its onset of action.
• Consuming high-fiber foods may impact the absorption of Paracetamol, especially in individuals with sensitive digestive systems.
• Eating spicy foods while taking this medication may irritate the stomach lining, potentially exacerbating gastrointestinal side effects.
• No significant food interactions are known to directly affect the effectiveness of Triprolidine, but consult your healthcare provider for personalized advice.

Paracetamol 300mg, Triprolidine 1.5mg Syrup/Suspension should be stored in a controlled environment, preferably at room temperature (around 25°C), away from excessive heat and moisture. Keep the bottle tightly sealed to maintain its integrity and prevent contamination. Ensure the medication is stored in its original container, labeled with the patient's name and prescription details. Do not use the medication if it shows signs of discoloration or if particles are visible. Dispose of any unused or expired medication responsibly by following local guidelines for pharmaceutical waste disposal, avoiding contamination of water sources or landfills. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Paracetamol 300mg, Triprolidine 1.5mg Syrup/Suspension:

• Always follow the dosage instructions provided by your doctor or pharmacist.
• Shake the bottle well before each use to ensure a proper mix.
• Use the measuring cup or syringe provided to measure the correct dose accurately.
• Administer the syrup directly into the mouth or mix it with a small amount of liquid or soft food.
• Avoid mixing with hot beverages as it may affect the medication's effectiveness.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Keep a record of your doses to ensure you're taking it as prescribed.