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Dextromethorphan, a component of Dextromethorphan, Guaifenesin capsules, acts centrally as a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist in the brainstem. This mechanism helps to suppress the cough reflex by raising the cough threshold. It also acts peripherally by inhibiting the afferent impulse transmission of the vagus nerve. Guaifenesin, the other active ingredient, is an expectorant that works by stimulating the respiratory tract's goblet cells to produce and secrete more fluid mucus, which aids in the removal of unwanted, accumulated mucus and enhances airway clearance.

dextromethorphan, Guaifenesin

Antitussive, expectorant.

Capsule

The following are the uses of dextromethorphan, Guaifenesin Capsule:

• Used for suppressing coughs and relieving symptoms of upper respiratory tract infections.
• Used for loosening mucus in the airways, making it easier to cough up.
• Used for reducing congestion in the chest and sinuses.
• Used for providing temporary relief from coughs caused by minor throat and airway irritation.
• Used for treating dry, unproductive coughs.
• Used for soothing sore throats and reducing the urge to cough.
• Used for aiding in the recovery from respiratory conditions by thinning and loosening mucus.
• Used for providing temporary comfort during periods of intense coughing.

In the case of an overdose of Dextromethorphan and Guaifenesin capsules, several symptoms may occur. These can include nausea, vomiting, dizziness, and in severe cases, hallucinations and rapid heart rate. Prompt medical attention is advised, as treatment may involve supportive care and monitoring vital signs. Seeking medical advice is crucial, especially if symptoms worsen or persist, to ensure appropriate management and prevent potential complications.

In the case of a missed dose of dextromethorphan and guaifenesin capsules, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking a family member to help you stay on track with your medication routine. It's important to maintain consistency when taking this medication for optimal effectiveness.

To take the dextromethorphan and Guaifenesin Capsule, swallow the capsule whole with a full glass of water, following the prescribed dosage instructions provided by your healthcare professional, typically one or two capsules every 4 to 6 hours as needed for cough and congestion relief.

Following are the conditions/situations when Dextromethorphan, Guaifenesin Capsule should not be used:

• Must not be used in individuals with a known allergy to Dextromethorphan, Guaifenesin, or any other similar antitussive or expectorant medications.
• Avoid using if you have a severe lung or breathing problem, such as asthma or chronic obstructive pulmonary disease (COPD), without consulting a doctor.
• Not suitable for individuals with a history of liver or kidney disease as it may worsen these conditions.
• Contraindicated in patients with a history of seizures or those taking medications that lower the seizure threshold.
• Should not be used in patients with a history of gastrointestinal blockage or difficulty swallowing.
• Avoid using this medication if you have recently taken a monoamine oxidase inhibitor (MAOI) or are currently using any other cough and cold medications.
• Do not give this medication to children under 4 years old without consulting a pediatrician.

The side effects of dextromethorphan, Guaifenesin Capsule may include:

• Drowsiness or dizziness
• Nausea and vomiting
• Dry mouth
• Constipation
• Diarrhea
• Stomach pain or upset
• Allergic reactions (such as rash, itching, swelling)
• Difficulty breathing or swallowing

Following are the precautions and warnings for Dextromethorphan, Guaifenesin Capsules:

• Not suitable for individuals with a known allergy to dextromethorphan, guaifenesin, or any other ingredients in the capsule.
• Patients with liver or kidney disease should use with caution, as these conditions may affect the metabolism and elimination of the medication.
• Avoid alcohol consumption while taking this medication, as it may increase the risk of side effects and impair your thinking or reactions.
• Do not exceed the recommended dosage, as excessive use can lead to serious side effects, including liver damage.
• Patients with diabetes should be cautious, as the medication may contain sugar, affecting blood sugar levels.
• May cause drowsiness, so avoid driving or operating heavy machinery until you know how this medication affects you.
• Consult a healthcare professional if you are pregnant, planning to become pregnant, or breastfeeding, as they can advise on the potential risks and benefits.
• Keep out of reach of children, and store at room temperature, away from moisture and heat.

Following are the drug interactions for Dextromethorphan, Guaifenesin Capsule:

• Monoamine oxidase inhibitors (MAOIs) should not be used with dextromethorphan, as it may cause serotonin syndrome, a serious and potentially fatal condition.
• Dextromethorphan can interact with other central nervous system (CNS) depressants like benzodiazepines, alcohol, or opioids, leading to increased sedation and respiratory depression.
• Anticholinergic drugs may interact, causing increased side effects such as dry mouth, blurred vision, and urinary retention.
• Medications metabolized by the CYP2D6 enzyme, such as certain antidepressants and antipsychotics, may have altered effects when taken with dextromethorphan.
• Dextromethorphan may increase the risk of bleeding when taken with anticoagulants or antiplatelet drugs.
• It can also interact with certain antibiotics, increasing the risk of side effects and altering therapeutic effects.
• Guaifenesin may interact with drugs that lower blood sugar, requiring close monitoring of glucose levels.

Following are the food interactions for Dextromethorphan, Guaifenesin Capsule:

• Avoid consuming alcohol with this medication as it can intensify side effects like drowsiness and dizziness, and may also impair your thinking and reactions.
• Grapefruit and grapefruit juice should be consumed with caution as they can increase the blood levels of Dextromethorphan, leading to potential side effects, especially related to the central nervous system.
• High-fat meals can decrease the absorption of Dextromethorphan, possibly reducing its effectiveness. It is advisable to take the medication on an empty stomach or with a light meal.
• Caffeine-containing beverages like coffee and energy drinks may further stimulate the central nervous system when taken with Dextromethorphan, potentially causing restlessness, nervousness, and insomnia.
• Avoid eating large amounts of chocolate, especially dark chocolate, as it contains a compound called theobromine, which can also stimulate the central nervous system and interact with Dextromethorphan.
• There are no specific food interactions with Guaifenesin, but maintaining adequate hydration is essential to help loosen mucus and facilitate its removal from the respiratory tract.
• Spicy foods may be beneficial as they can help thin mucus and ease congestion, supporting the expectorant action of Guaifenesin.
• Ensure a balanced diet to support overall health and recovery, especially focusing on foods rich in antioxidants and vitamins, which can aid in immune function and respiratory health.

Dextromethorphan, Guaifenesin capsules should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature (between 68°F and 77°F). Keep the capsules in their original packaging, away from direct sunlight, moisture, and heat sources such as radiators or ovens, as extreme temperatures can degrade the medication. Always check the expiration date, and never use the capsules beyond this date. When disposing of unused or expired capsules, do not flush them down the toilet or throw them into the garbage. Instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for safe disposal options. It is crucial to keep all medications out of the reach of children and pets to prevent accidental ingestion.

Following are the quick tips for Dextromethorphan, Guaifenesin Capsule:

• Consult your healthcare provider for dosage instructions specific to your condition.
• Swallow the capsule whole; do not crush, chew, or open it.
• Stay well-hydrated while taking the medication to help loosen congestion.
• Avoid taking with dairy products as they may interfere with absorption.
• If you experience nausea, taking the capsule with a light snack may help.
• Ensure you complete the full course of medication, even if you feel better earlier.
• Store the capsules in a cool, dry place, away from direct sunlight.