ADRIBLASTINA 50MG ING

Doxorubicin HCl's primary mechanism of action is through its interaction with DNA. Once inside the cell, doxorubicin intercalates between DNA base pairs, inserting itself into the DNA structure. This intercalation process disrupts the normal function of DNA, inhibiting DNA replication and RNA synthesis. Doxorubicin also induces DNA damage by generating reactive oxygen species (ROS) that interfere with the DNA repair process, leading to cell cycle arrest and eventually triggering programmed cell death (apoptosis) in rapidly dividing cancer cells. The drug's ability to disrupt DNA activity makes it effective in slowing or stopping the growth of cancer cells.

Doxorubicin HCl 50MG

Anthracycline antibiotic

Injection

The following are the uses of Doxorubicin HCl 50MG Injection:

• Used for treating various types of cancer, including breast cancer, ovarian cancer, and bladder cancer.
• Used for slowing down or stopping the growth of cancer cells by interfering with their DNA.
• Used for shrinking tumors to improve symptoms and quality of life.
• Used for managing certain types of leukemia and lymphoma.
• Used for preventing the spread of cancer to other parts of the body.
• Used as part of a combination therapy with other cancer medications.
• Used for reducing the risk of cancer recurrence after initial treatment.

In the case of an overdose of Doxorubicin HCl 50MG Injection, prompt medical intervention is necessary. Symptoms may include an intensified version of the drug's side effects, such as severe nausea, vomiting, and potentially life-threatening heart issues. Medical professionals should closely monitor the patient's vital signs and provide supportive care. Immediate treatment can significantly impact the patient's recovery and minimize the long-term consequences of this potent medication.

In the case of a missed dose of Doxorubicin HCl 50MG Injection, it is important to consult your healthcare provider for guidance. Generally, if a dose is missed, it is best to skip the missed dose and continue with the next scheduled dose as directed. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, inform your doctor, who can advise on adjusting the dosing schedule to ensure the treatment remains effective.

To administer Doxorubicin HCl 50MG Injection, reconstitute the powder with the provided sterile diluent, gently swirl the vial to ensure complete dissolution, and withdraw the medication into a syringe; then slowly inject it intravenously over 5-10 minutes, ensuring the injection site is clean and as directed by your healthcare professional.

Following are the conditions or circumstances when Doxorubicin HCl 50MG Injection should not be administered:

• Not recommended for patients with a known hypersensitivity or severe allergic reaction to Doxorubicin HCl or any of its excipients.
• Contraindicated in patients with a history of severe heart disease, including those with impaired heart function or previous heart damage.
• Should not be used in patients with a low white blood cell count (neutropenia) or a history of bone marrow suppression.
• Not suitable for pregnant or breastfeeding women due to potential harm to the fetus or infant.
• Avoid in patients with active infection, as it may mask the signs of infection.
• Not recommended for patients with a history of previous treatment with doxorubicin or other anthracyclines, as it may increase the risk of cardiac toxicity.
• Doxorubicin HCl should not be used in patients with a known tumor invasion of the skin at the injection site.
• Contraindicated in patients with a history of radiation therapy to the chest area.

The side effects of Doxorubicin HCl 50MG Injection may include:

• Nausea and vomiting
• Hair loss (alopecia)
• Mouth sores
• Diarrhea
• Fatigue and weakness
• Skin reactions, such as rash or hand-foot syndrome
• Heart problems, including decreased heart function and abnormal heart rhythms
• Bone marrow suppression, leading to low blood cell counts

Following are the precautions and warnings for Doxorubicin HCl 50MG Injection:

• This medication should be administered under the strict supervision of a qualified healthcare professional due to its potential for serious side effects.
• Not recommended for patients with a known hypersensitivity to Doxorubicin or other anthracyclines.
• Cardiovascular function should be closely monitored during and after treatment. Doxorubicin may cause cardiomyopathy and congestive heart failure.
• Regular blood tests are required to monitor liver and kidney function, as well as blood cell counts, due to potential toxicity.
• Avoid in patients with a history of severe liver or kidney impairment, as dosage adjustments may be necessary.
• Doxorubicin can cause severe myelosuppression, leading to decreased white blood cell counts and increased risk of infection. Close monitoring is essential.
• Not recommended for use during pregnancy as it may cause harm to the fetus. Effective contraception is advised for both male and female patients.
• Exercise caution when administering to elderly patients, as they may be more susceptible to side effects and toxicity.

Following are the drug interactions for Doxorubicin HCl 50MG Injection:

• Concurrent use with other cardiotoxic medications (e.g., cyclophosphamide, trastuzumab) can increase the risk of heart damage and arrhythmias.
• Doxorubicin may reduce the effectiveness of live vaccines, and vaccination with live vaccines should be avoided during treatment.
• Interactions with bone marrow suppressants (e.g., cytarabine, cisplatin) can increase the risk of myelosuppression and infection.
• The risk of bleeding may increase when combined with anticoagulants like warfarin or heparin.
• Caution is advised when using with other ototoxic drugs (e.g., cisplatin, aminoglycosides), as it may enhance hearing loss.
• Anticonvulsants like phenytoin or carbamazepine may decrease the effectiveness of Doxorubicin.
• Doxorubicin can increase the concentration of certain medications, including some antibiotics (clarithromycin) and antifungals (ketoconazole).

Following are the food interactions for Doxorubicin HCl 50MG Injection:

• Grapefruit and grapefruit juice consumption should be avoided as they can alter the metabolism of Doxorubicin, potentially leading to increased toxicity.
• Alcohol should be strictly avoided as it can enhance the risk of liver damage and worsen the side effects of the medication.
• Avoid high-fat meals as they may interfere with the absorption and distribution of the drug, potentially affecting its effectiveness.
• Black cohosh supplements may interact, leading to increased cardiotoxicity.
• Limit or avoid foods rich in tyramine (aged cheeses, cured meats) as Doxorubicin can inhibit monoamine oxidase, potentially causing a hypertensive crisis.
• Green tea and its extracts might reduce the effectiveness of Doxorubicin due to their antioxidant properties.
• Vitamin E supplements should be used with caution as they may also interfere with the anticancer activity of the drug.
• Always consult your healthcare provider for specific dietary recommendations during Doxorubicin treatment.

Doxorubicin HCl 50MG Injection should be stored in a controlled environment, specifically in a cool and dry place at room temperature, ensuring protection from light and moisture. It is crucial to maintain the integrity of the medication by keeping it in its original packaging, tightly sealed, and away from direct exposure to air. When handling and storing this injection, always exercise caution and adhere to safety guidelines to prevent accidental contact or contamination. Disposal of unused or expired medication should be done responsibly; do not flush or pour it down the drain. Contact your healthcare provider or pharmacist for guidance on proper disposal methods to ensure environmental safety. Keep this medication out of children's reach to prevent accidental exposure and potential harm.

Following are the quick tips for Doxorubicin HCl 50MG Injection:

• Administer the injection under medical supervision for accurate dosage and safe administration.
• Ensure the injection is prepared and handled by trained medical professionals.
• Follow the prescribed dosage and treatment schedule for best results.
• Avoid missing doses; if a dose is missed, consult your doctor for instructions.
• Do not stop the medication without consulting your healthcare provider.
• Inform your doctor about all medications you are taking to prevent drug interactions.
• Report any unusual symptoms or side effects to your healthcare team immediately.
• Store the injection as directed, away from sunlight and moisture.