ADRIBLASTINA IMP 10MG INJ

Doxorubicin HCl, a potent chemotherapy medication, exerts its mechanism of action through multiple pathways. It primarily acts as a DNA intercalator, inserting itself between DNA base pairs, which disrupts the DNA helix and interferes with vital cellular processes like replication and transcription. This interference leads to DNA damage and triggers cell cycle arrest, predominantly at the G2/M phase, ultimately resulting in cell death. Furthermore, Doxorubicin generates reactive oxygen species (ROS) that contribute to cellular stress and damage, particularly affecting cancer cells due to their higher metabolic rates and weaker antioxidant defenses. This dual mechanism of action makes Doxorubicin HCl a powerful tool in cancer treatment, targeting cancer cells through DNA disruption and oxidative stress.

Doxorubicin HCl 10MG

Anthracycline antibiotic

Injection

The following are the uses of Doxorubicin HCl 10MG Injection:

• Used for treating various types of cancer, including breast, ovarian, bladder, and lung cancers.
• Used for slowing or stopping the growth of cancer cells.
• Used for shrinking tumors to improve patient symptoms.
• Used as part of chemotherapy regimens to enhance overall treatment effectiveness.
• Used for its ability to interfere with DNA replication in rapidly dividing cells.
• Used to manage certain types of leukemia and lymphoma.
• Used as an adjuvant therapy to reduce the risk of cancer recurrence.

In the case of an overdose of Doxorubicin HCl 10MG Injection, immediate medical intervention is necessary. Symptoms may include severe nausea, vomiting, and a significant decrease in white blood cell count, leaving the patient vulnerable to infections. Cardiac issues such as arrhythmias and congestive heart failure may also occur. Prompt treatment involves supportive care, managing symptoms, and potentially administering specific antidotes under medical supervision to mitigate the effects of the overdose.

In the case of a missed dose of Doxorubicin HCl 10MG Injection, it is important to consult your healthcare provider or oncologist promptly. They will provide specific instructions for your situation. Generally, it is recommended to administer the missed dose as soon as possible, but if it is close to the time for your next scheduled dose, you may be advised to skip the missed dose to maintain the treatment schedule. Never double the dose to make up for a missed one without medical guidance.

To administer Doxorubicin HCl 10MG Injection, ensure the medication is prepared by a healthcare professional; they will dissolve the powder with the provided diluent and mix it thoroughly, then inject the solution intravenously, typically over 5-10 minutes, following the prescribed dosage and schedule determined by your doctor.

Here are the conditions or situations when Doxorubicin HCl 10MG Injection should not be used:

• Should not be administered to patients with a known allergy or hypersensitivity to Doxorubicin HCl or any of its components.
• Contraindicated in patients with severe heart diseases, including congestive heart failure, recent heart attack, or severe arrhythmias.
• Not recommended for individuals with severe liver impairment or active liver disease.
• Avoid in patients with a history of previous radiation therapy to the chest area.
• Should not be used during pregnancy as it may cause harm to the fetus.
• Contraindicated in patients with a low white blood cell count (neutropenia) or low platelet count (thrombocytopenia).
• Not suitable for individuals with active infection or severe immunodeficiency.

The side effects of Doxorubicin HCl 10MG Injection may include:

• Nausea and vomiting
• Hair loss (alopecia)
• Mouth sores
• Fatigue and weakness
• Skin reactions, such as rash or itching
• Decreased appetite
• Heart damage (cardiotoxicity), which may lead to an irregular heartbeat or heart failure
• Increased risk of infection due to a decrease in white blood cells

Following are the precautions and warnings for Doxorubicin HCl 10MG Injection:

• This medication is a potent anticancer drug and should be used with extreme caution. It should only be administered by trained medical professionals in a controlled medical setting.
• Doxorubicin can cause severe myelosuppression, leading to decreased white blood cell, red blood cell, and platelet counts. Regular blood tests are necessary to monitor these levels.
• Patients may experience severe nausea and vomiting. Antiemetic medications may be prescribed to manage these side effects.
• Cardiotoxicity is a serious concern, including the potential for irreversible heart damage. Regular cardiac monitoring is essential, and patients with pre-existing heart conditions are at higher risk.
• Doxorubicin can cause hair loss, which is usually temporary but may be permanent in some cases.
• It may cause discoloration of the skin, nails, and mucous membranes, which is more noticeable in areas exposed to sunlight. Sun protection is advised.
• This drug should be used with caution in patients with liver disease, as it is metabolized by the liver.
• Doxorubicin can harm unborn babies; pregnant women should avoid it. Effective contraception is essential during treatment.

Following are the drug interactions for Doxorubicin HCl 10MG Injection:

• Co-administration with other cardiotoxic medications (e.g., cyclophosphamide, trastuzumab) may increase the risk of cardiac toxicity and heart failure.
• Doxorubicin can enhance the myelosuppressive effects of other chemotherapy drugs, leading to increased risk of neutropenia and thrombocytopenia.
• The use of Doxorubicin with radiation therapy can exacerbate radiation-induced skin reactions and tissue damage.
• Avoid concurrent use with live vaccines, as Doxorubicin may diminish the immune response to vaccination.
• Caution is advised when combining with drugs that affect liver function, as Doxorubicin is metabolized by the liver.
• Interactions with immunosuppressants may lead to increased immunosuppression and potential for infections.
• Doxorubicin may decrease the effectiveness of hormonal contraceptives, requiring alternative methods of birth control.

Following are the food interactions for Doxorubicin HCl 10MG Injection:

• Avoid grapefruit and grapefruit juice as they can alter the drug's metabolism, leading to increased levels of Doxorubicin in the body and potentially enhancing its side effects.
• Alcohol consumption should be limited or avoided as it may increase the risk of liver toxicity and exacerbate the side effects of Doxorubicin.
• Avoid high-fat meals as they may interfere with the absorption of Doxorubicin, potentially reducing its effectiveness.
• Ensure adequate hydration before and after the injection to reduce the risk of kidney damage.
• Avoid foods rich in Vitamin K (like spinach, kale, and broccoli) as Doxorubicin can interact with Vitamin K, affecting blood clotting.
• Patients should maintain a balanced diet rich in antioxidants to help manage the oxidative stress caused by the medication.
• Certain herbal supplements like St. John's Wort may interact with Doxorubicin, so it's best to consult a healthcare professional before taking any herbal remedies.
• No significant food interactions directly impact the drug's action, but individual responses may vary, so monitoring for any unusual reactions is essential.

Doxorubicin HCl 10MG Injection should be stored with utmost care, preferably in a secure and designated medication storage area. Maintain a cool and dry environment, ideally at room temperature, ensuring protection from direct sunlight and moisture. Keep the injection in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Avoid placing it in bathrooms or near heat-emitting appliances, as temperature fluctuations can impact its efficacy. Always adhere to the expiration date, and when disposing of the injection, refrain from flushing or pouring it down the drain. Consult your pharmacist or healthcare provider for environmentally friendly disposal methods. Lastly, ensure the medication is stored out of children's reach to prevent accidental exposure.

Following are the quick tips for Doxorubicin HCl 10MG Injection:

• Administer the injection under medical supervision; do not self-inject.
• Ensure the injection is prepared and handled by trained medical professionals.
• Follow the prescribed dosage and schedule provided by your healthcare provider.
• Avoid contact with skin and eyes during preparation and administration.
• Do not reuse needles, syringes, or other injection materials.
• Dispose of all injection materials properly according to local guidelines.
• Inform your doctor if you experience any side effects or unusual symptoms.
• Store the injection as directed, away from light and moisture.