AFLOXAN 300MG TAB

Proglumetacin, a component of Proglumetacin 300MG Tablet, is a prodrug that is metabolized in the body to produce the active metabolite, mefenamic acid. Mefenamic acid primarily exerts its anti-inflammatory, analgesic, and antipyretic effects by inhibiting the enzyme cyclooxygenase (COX), which is responsible for the synthesis of prostaglandins. By blocking COX, proglumetacin reduces the production of prostaglandins, which are key mediators of inflammation and pain. This mechanism helps in alleviating symptoms associated with inflammation, such as swelling, redness, and pain, making it effective in managing conditions like rheumatoid arthritis, osteoarthritis, and mild to moderate pain.

Non-steroidal anti-inflammatory drug (NSAID)

Tablet

The following are the uses of Proglumetacin 300MG Tablet:

• Used for relieving pain and reducing inflammation caused by rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
• Used to alleviate acute pain, such as post-operative pain or pain due to dental procedures.
• Effective in reducing swelling and discomfort associated with sports injuries and sprains.
• Helps manage pain and stiffness in the neck, back, and joints.
• Can be used to treat pain and inflammation in conditions like tendonitis and bursitis.
• Provides relief from menstrual cramps and discomfort.
• May be prescribed for short-term pain relief in various other conditions as determined by a healthcare professional.

In the case of an overdose of Proglumetacin 300MG Tablets, individuals may experience symptoms such as gastrointestinal bleeding, kidney damage, or liver dysfunction. Prompt medical intervention is necessary to manage the overdose effectively. Treatment may include gastric lavage, activated charcoal administration, and supportive care to address any organ-related complications. It is crucial to seek emergency medical assistance if an overdose is suspected to ensure appropriate and timely treatment.

In the case of a missed dose of Proglumetacin 300MG Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. It is generally recommended not to double the dose to make up for a missed one. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track. It is always best to consult your healthcare provider for specific instructions regarding missed doses, especially if you miss multiple doses.

To take Proglumetacin 300MG Tablet, swallow the tablet whole with a full glass of water, preferably with or after a meal, once or twice a day as directed by your healthcare professional.

Here are the circumstances under which Proglumetacin 300MG Tablet should be avoided:

• Must not be taken by individuals with a known allergy to Proglumetacin or any non-steroidal anti-inflammatory drugs (NSAIDs).
• Contraindicated in patients with severe kidney or liver impairment.
• Not suitable for individuals who have experienced asthma attacks, hives, or allergic reactions after taking aspirin or other NSAIDs.
• Should be avoided during the last trimester of pregnancy due to potential fetal harm.
• Contraindicated in patients with active peptic ulcers or a history of gastrointestinal bleeding.
• Not recommended for individuals with severe heart failure or high blood pressure that is not controlled by medication.
• Avoid using it just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

The side effects of Proglumetacin 300MG Tablet may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea or constipation
• Dizziness or lightheadedness
• Headache
• Skin rash or itching
• Increased blood pressure
• Allergic reactions (e.g., swelling of the face, lips, or throat)

Following are the precautions and warnings for Proglumetacin 300MG Tablet:

• Do not take this medication if you have a known allergy or hypersensitivity to Proglumetacin or any other non-steroidal anti-inflammatory drugs (NSAIDs).
• Exercise caution if you have a history of gastrointestinal bleeding, ulcers, or other gastrointestinal disorders, as this medication may increase the risk of gastrointestinal complications.
• Patients with cardiovascular disease, hypertension, or a history of stroke/heart attack should use this medication with caution as it may increase the risk of cardiovascular events.
• Proglumetacin may cause renal impairment, especially in patients with pre-existing kidney problems. Regular monitoring of kidney function is advised.
• Avoid using this medication during pregnancy, especially in the third trimester, as it may affect fetal development. Consult your doctor for alternative options.
• This medication may pass into breast milk, therefore, breastfeeding women should use it with caution and consult a healthcare professional.
• If you experience any signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing, discontinue use and seek immediate medical attention.
• Always inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.

Following are the drug interactions for Proglumetacin 300MG Tablet:

• Proglumetacin may interact with ACE inhibitors (e.g., enalapril, lisinopril) and increase the risk of kidney problems, especially in patients with existing kidney disease.
• Combining Proglumetacin with diuretics (e.g., furosemide, hydrochlorothiazide) can reduce their diuretic and antihypertensive effects.
• The risk of gastrointestinal bleeding may increase when Proglumetacin is taken with corticosteroids like prednisone.
• It can interact with anticoagulants (e.g., warfarin, heparin), potentially increasing the risk of bleeding complications.
• Proglumetacin may reduce the effectiveness of beta-blockers (e.g., metoprolol, propranolol) in managing cardiovascular conditions.
• Concomitant use with other NSAIDs or salicylates may lead to increased adverse effects and a higher risk of gastrointestinal toxicity.
• Caution is advised when using Proglumetacin with medications that affect the liver, as it may increase the risk of liver-related side effects.

Following are the food interactions for Proglumetacin 300MG Tablet:

• Alcohol consumption should be avoided as it can increase the risk of gastrointestinal bleeding and liver toxicity.
• Grapefruit and grapefruit juice are to be avoided as they may increase the concentration of the drug in the body, potentially leading to increased side effects.
• Dairy products like milk, cheese, and yogurt can reduce the absorption of Proglumetacin, so it is best to take the medication at least 2 hours before or after consuming dairy.
• Foods rich in vitamin K, such as spinach, broccoli, and kale, may interfere with the blood-thinning effects of Proglumetacin when used for its anti-platelet properties.
• Avoid high-sodium foods, as Proglumetacin can increase sodium retention, and excessive sodium intake may worsen hypertension.
• Limit the consumption of fatty and fried foods as they can increase the risk of gastrointestinal side effects and may interfere with the absorption of the medication.
• Caffeinated beverages like coffee and energy drinks should be consumed in moderation, as they may enhance the stimulatory effects of Proglumetacin on the central nervous system.
• There is no specific food interaction with Proglumetacin regarding sugar intake, but maintaining a balanced diet is advisable to manage overall health.

Proglumetacin 300MG Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, away from direct sunlight, moisture, and heat. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to air and humidity. It is crucial not to store them in the bathroom or kitchen, as these areas can have fluctuating temperatures and humidity levels. Regularly check the expiration date, and if the tablets are past their expiry, do not consume them and dispose of them safely. Proper disposal methods should be followed, such as returning them to a pharmacy or healthcare facility for appropriate waste management, ensuring they are not flushed down the toilet or disposed of in ways that may harm the environment. Keep all medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Proglumetacin 300MG Tablet:

• Consult a doctor for a proper prescription and dosage instructions.
• Swallow the tablet with a full glass of water, do not crush or chew.
• Take the tablet with or after meals to minimize stomach irritation.
• Avoid alcohol consumption while taking this medication.
• Inform your doctor about any other medications or supplements you are using.
• Do not take this medication if you are allergic to proglumetacin or similar drugs.
• Store the tablets in a cool, dry place, away from direct sunlight.
• Seek immediate medical attention if you experience severe side effects.