ALBUMAN 20% 50ML INJ

Human Albumin injection works primarily by restoring and maintaining intravascular volume. It is a colloid that exerts osmotic pressure within the blood vessels, helping to draw and retain fluid in the circulatory system. The albumin protein in the injection is similar to the naturally occurring albumin in the human body, and it acts as a carrier protein, binding and transporting various substances such as lipids, hormones, and certain drugs. By increasing plasma volume, it helps improve microvascular perfusion and ensures adequate blood supply to vital organs and tissues. This mechanism is particularly beneficial in conditions where hypovolemia or low albumin levels are present, aiding in the maintenance of circulatory stability and supporting tissue oxygenation.

Human Albumin

Plasma volume expander

injection

The following are the uses of Human Albumin injection:

• Used for restoring blood volume in trauma, burns, and surgery patients, improving circulation.
• Used for treating severe hypovolemia, providing volume expansion.
• Used in liver diseases to improve circulation and nutrient supply.
• Used for stabilizing blood pressure during critical care.
• Used post-transplant to support organ function and recovery.
• Used in nephrotic syndrome to manage edema and low albumin levels.
• Used to treat severe malnutrition, aiding nutrient absorption.

In the case of an overdose of Human Albumin injection, the primary concern is fluid overload. Symptoms may include difficulty breathing, swelling in the extremities, and increased blood pressure. Treatment involves monitoring fluid intake and output, ensuring proper ventilation, and potentially administering diuretics to manage fluid balance. Prompt medical assessment is vital to determine the severity of the overdose and initiate appropriate supportive care.

In the case of a missed dose of Human Albumin injection, it is important to contact your healthcare provider or seek medical advice promptly. The appropriate action for a missed dose may vary depending on the specific treatment plan and the reason for using the injection. Your healthcare provider will be able to guide you on whether to administer the missed dose or simply continue with the next scheduled dose, ensuring that you receive the correct treatment and minimizing any potential risks associated with missed doses.

To administer the Human Albumin injection, clean the injection site with an alcohol swab, insert the needle at a 45-degree angle, inject the prescribed dose slowly, and then gently remove the needle and apply pressure with a sterile gauze pad to prevent any bleeding.

Following are the conditions when Human Albumin injection should be avoided or used with caution:

• Not to be administered to patients with a known hypersensitivity or severe allergic reaction to human albumin or any excipients in the formulation.
• Avoid use in patients with severe anemia or severe hypovolemia, as it may exacerbate these conditions.
• Contraindicated in patients with severe heart failure or severe hypertension, as it may overload the circulatory system.
• Should not be used in patients with a history of stroke or recent cardiovascular events.
• Avoid use in patients with severe kidney disease or on dialysis, as it may affect fluid balance.
• Not recommended for patients with a known history of anaphylactic reactions to human blood products.
• Contraindicated in patients with severe respiratory distress syndrome.
• Should not be administered to patients with a known history of immunoglobulin A (IgA) deficiency or antibodies to IgA.
• Not suitable for patients with severe liver disease or acute liver failure.

The side effects of Human Albumin Injection may include:

• Allergic reactions such as hives, itching, or rash.
• Fever or chills.
• Nausea and vomiting.
• Rapid or pounding heartbeat.
• Difficulty breathing or chest pain.
• Swelling or fluid overload, particularly in individuals with heart or kidney conditions.
• Hypotension (low blood pressure).
• Pain, swelling, or redness at the injection site.

Here are the precautions and warnings for Human Albumin Injection:

• Human Albumin should be administered under medical supervision with access to appropriate monitoring and supportive care facilities.
• Ensure accurate volume and rate of administration, as rapid infusion may result in cardiovascular overload, especially in vulnerable patients.
• Monitor for signs of circulatory overload, particularly in patients with cardiovascular disease or hypertension.
• Not recommended for patients with severe anemia or cardiac disease due to potential volume overload.
• Patients with a history of allergic reactions to albumin products or any component of the formulation should be carefully evaluated.
• May interfere with certain laboratory tests, so inform laboratories of recent albumin administration.
• Use with caution in neonates, especially premature infants, due to the risk of fluid and electrolyte imbalances.
• Consult healthcare professionals for specific guidelines and dosage adjustments based on individual patient needs.

Following are the drug interactions for Human Albumin injection:

• May interact with ACE inhibitors, potentially leading to increased hypotensive effects, especially in patients with intravascular volume depletion.
• Use with caution alongside anticoagulants as it may enhance anticoagulant effect.
• When combined with sympathomimetic agents, it can lead to increased blood pressure and reduced diuretic effectiveness.
• Human Albumin can interact with diuretics, causing decreased diuretic effect and potential fluid overload.
• May reduce the effectiveness of vaccines, especially live-attenuated vaccines, due to its immune-modulating properties.
• Can interact with heparin, increasing the risk of bleeding.
• May decrease the effectiveness of platelet inhibitors, requiring careful monitoring.

Following are the food interactions for Human Albumin Injection:

• Avoid excessive salt (sodium) intake as Human Albumin may cause sodium retention, leading to fluid build-up.
• Restrict fluid intake as directed by your healthcare provider to prevent fluid overload.
• Patients with liver disease should limit protein intake, and Human Albumin, being a protein, should be used with caution.
• Alcohol should be consumed in moderation, as it can affect liver function and potentially impact the metabolism of albumin.
• Avoid grapefruit and grapefruit juice, as they may interfere with albumin metabolism and increase the risk of adverse effects.
• Ensure an adequate diet to maintain nutritional balance, especially in long-term Human Albumin therapy.
• Consult a dietician or healthcare provider for personalized dietary recommendations during Human Albumin treatment.

Storage and disposal of Human Albumin injection require specific attention to maintain its integrity and ensure safety. Store the injection at room temperature, between 20-25°C (68-77°F), in a dry and dark place, away from direct sunlight and heat sources. Avoid freezing the injection as it may affect its potency. Always keep the injection in its original packaging to protect it from light and moisture. Before administration, inspect the solution for any discoloration or particulate matter; discard if any abnormalities are noticed. Do not use the injection if the seal is broken or damaged. Dispose of any unused or expired Human Albumin injection through a medicine take-back program or by following local guidelines for pharmaceutical waste disposal, ensuring it is out of reach of children and pets.

Following are the quick tips for Human Albumin Injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the correct dosage and injection site as prescribed.
• Store the injection at room temperature, away from direct sunlight.
• Do not use if the solution appears cloudy or contains particles.
• Report any signs of allergic reaction or severe side effects immediately.
• Dispose of used needles and syringes safely in designated sharps containers.
• Keep a record of injection dates and dosage for future reference.