ALBUMIN 50ML 20% INJ (BIOTEST)

Albumin injection works primarily by increasing colloid osmotic pressure in the circulation. Albumin is a protein that plays a crucial role in maintaining the volume of blood plasma and transporting various substances in the body. When administered, it helps to draw and retain fluid in the blood vessels, thereby increasing blood volume. This mechanism is particularly beneficial in conditions where blood volume is low due to trauma, burns, surgery, or certain diseases. By increasing blood volume, albumin injection helps improve microcirculation, ensures adequate tissue perfusion, and supports the maintenance of normal fluid balance in the body. This action is essential in preventing or treating hypovolemia and shock, and it can also aid in the distribution of other medications or nutrients that are co-administered.

Albumin

plasma volume expander

Injection

The following are the uses of Albumin Injection:

• Used for restoring lost blood volume in trauma, burns, and surgery.
• Used to treat low albumin levels in liver disease, kidney disease, and malnutrition.
• Useful for maintaining blood pressure and fluid balance in critical care settings.
• Used to prevent fluid loss and improve recovery in severe injuries.
• Aids in maintaining osmotic pressure and nutrient transport in the body.
• Used to support blood circulation and organ function during medical procedures.
• Provides essential proteins to promote healing and tissue repair.

In the case of an overdose of Albumin Injection, it is important to seek medical advice promptly. Symptoms of an overdose may include increased blood volume, hypertension, and potential fluid overload. Treatment involves monitoring vital signs, assessing fluid status, and providing supportive care. Prompt medical intervention is key to managing any adverse effects and ensuring patient safety. It is crucial to recognize and address the signs of an overdose to prevent further complications.

In the case of a missed dose of Albumin Injection, it is important to contact your healthcare provider for guidance. Do not double the dose to make up for a missed one. The timing and frequency of albumin injections are crucial, as they are often administered to treat specific medical conditions. Your healthcare provider will determine the appropriate action based on your individual treatment plan and medical history. They may advise you to reschedule the missed dose or provide specific instructions to ensure the treatment remains effective.

To administer the Albumin Injection, draw the prescribed dose into a syringe, ensuring the injection site is clean, and then insert the needle subcutaneously or intramuscularly at a 45-degree angle, slowly pushing the plunger to inject the medication as directed by your healthcare provider.

Following are the conditions/situations when Albumin Injection should not be administered:

• Should not be used in individuals with a known allergy or hypersensitivity to human albumin or any of the excipients in the formulation.
• Contraindicated in patients with severe anemia or severe cardiac and/or pulmonary disease, as it may lead to fluid overload.
• Not recommended for individuals with a history of severe or multiple allergies, as they may be more prone to allergic reactions.
• Should be avoided in patients with severe low blood volume or shock, as it may not effectively restore blood volume.
• Not suitable for patients with conditions where volume expansion is not desired, such as pulmonary edema or severe renal disease.
• Should not be administered to individuals with a history of coagulation disorders or those taking anticoagulant medications, as it may interfere with blood clotting.
• Contraindicated in patients with conditions where increased oncotic pressure is detrimental, such as severe hypertension or hyperviscosity syndromes.

The possible side effects of Albumin Injection may occur in the following forms:

• Allergic reactions such as hives, itching, or difficulty breathing.
• Nausea and vomiting.
• Fever or chills.
• Rapid or weak heartbeat.
• Swelling or edema, particularly in the hands, feet, or face.
• Chest pain or discomfort.
• Decreased urine output.
• Skin rash or itching.

Following are the precautions and warnings for Albumin Injection:

• Allergic reactions are possible; ensure the patient does not have a history of allergies to albumin or any other components in the injection.
• Monitor patients closely for signs of circulatory overload, especially in patients with cardiovascular disease or hypertension.
• Use with caution in patients with severe anemia, as it may mask the underlying condition.
• Do not use if the solution is cloudy or contains particulate matter.
• Not recommended for patients with severe hypoalbuminemia, as it may not be effective in these cases.
• Elderly patients may require careful monitoring due to the potential for increased sensitivity to the injection.
• Patients with a history of cardiac issues should be closely monitored for any cardiac-related complications.

Following are the drug interactions for Albumin Injection:

• Albumin may reduce the effectiveness of other medications such as tricyclic antidepressants, benzodiazepines, and phenytoin, as it can bind to these drugs and decrease their availability.
• Concomitant use with diuretics may lead to volume overload, especially in patients with heart or kidney issues.
• Anticoagulants like heparin or warfarin can have their effects altered, as albumin plays a role in binding and transporting these drugs.
• The effectiveness of insulin and other diabetes medications might be influenced, as albumin is involved in insulin transport.
• Albumin can impact the distribution of highly protein-bound drugs like warfarin, phenytoin, and valproic acid, potentially altering their therapeutic effects.
• In patients receiving albumin and ACE inhibitors, close monitoring is advised due to the potential for hypotension and decreased renal function.
• The use of albumin may reduce the efficacy of vaccines by interfering with the immune response, particularly live-attenuated vaccines.

Following are the food interactions for Albumin Injection:

• Albumin injection may lead to fluid overload, so it is important to monitor fluid intake, especially with high-sodium foods like processed snacks, canned soups, and salty condiments.
• Restrict excessive caffeine consumption from coffee, tea, or energy drinks as it can affect blood volume and hydration status.
• Avoid alcohol as it can impact liver function and potentially interfere with albumin metabolism.
• High-protein foods such as meat, eggs, and dairy can support albumin production and overall protein status.
• Consuming a balanced diet with a variety of fruits, vegetables, and whole grains ensures adequate micronutrients for albumin synthesis.
• Stay hydrated by drinking enough water to maintain proper blood volume and support albumin's osmotic functions.
• Avoid grapefruit and grapefruit juice as they may interfere with drug metabolism, potentially affecting medications administered alongside albumin injection.
• Consult a healthcare professional for personalized dietary advice, especially if there are underlying health conditions or specific treatment protocols.

Albumin Injection should be stored and disposed of carefully to maintain its integrity and ensure safety. Store the injection at room temperature, between 20-25°C (68-77°F), in a dry and dark place, away from direct sunlight and moisture. Keep the vial in its original packaging until ready for use, ensuring it remains sealed and protected from contamination. Do not freeze the injection as it may damage the protein structure. When disposing of unused or expired Albumin Injection, do not throw it in the trash or pour it down the drain. Contact your healthcare provider or pharmacist for instructions on proper disposal methods to protect the environment and prevent misuse. Keep this medication away from children to prevent accidental exposure.

Following are the quick tips for Albumin Injection:

• Administer the injection under medical supervision for best practices.
• Ensure the injection is stored at room temperature, away from direct sunlight.
• Before injection, inspect the solution for any discoloration or particles.
• Use a sterile syringe and needle for the injection process.
• Inject the solution slowly into the vein as directed by your healthcare provider.
• Rotate injection sites to minimize skin irritation and discomfort.
• After injection, properly dispose of used needles and syringes in a designated sharps container.
• Stay hydrated and inform your doctor if you experience any adverse reactions.