Alendroflex D (70mg/2800IU) 4 Tablets

Alendroflex D (70mg/2800IU) 4 Tablets

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  • Manufacturer NOVINS INTERNATIONAL
  • Generic Name

    Alendronate 70mg, Cholecalciferol 70mcg

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Alendronate, a component of the Alendronate 70mg, Cholecalciferol 70mcg Tablet, is a bisphosphonate medication that primarily acts by inhibiting osteoclast-mediated bone resorption. It does so by binding to the surface of active bone-resorbing sites, thus preventing the breakdown of bone tissue. This mechanism promotes bone mineralization and increases bone density. Cholecalciferol, also known as Vitamin D3, is essential for calcium absorption and bone metabolism. It works by binding to the vitamin D receptor in the body, which then promotes the absorption of calcium in the intestines and the reabsorption of calcium in the kidneys, ultimately contributing to the maintenance of bone health. When combined, these two components synergistically work to prevent bone loss and promote overall bone strength.

  • Ingredients

    Alendronate 70mg, Cholecalciferol 70mcg

  • Drug Class

    Bisphosphonate, Vitamin D

  • Dosage Form

    Oral

  • Uses

    The following are the uses of Alendronate 70mg, Cholecalciferol 70mcg Tablet:

    • Used for treating osteoporosis, strengthening bones, and reducing the risk of fractures.
    • Used for managing Paget's disease of bone, a condition affecting bone metabolism.
    • Used for correcting vitamin D deficiency, essential for calcium absorption and bone health.
    • Used for preventing and treating bone loss in various medical conditions.
    • Used for improving bone density and reducing pain in osteoporosis patients.
    • Used for supporting bone health and preventing fractures in postmenopausal women.
    • Used for promoting bone healing and recovery after fractures or bone surgeries.
  • In case of Overdose

    In the case of an overdose of Alendronate 70mg and Cholecalciferol 70mcg Tablets, individuals may experience a range of symptoms. These can include gastrointestinal issues such as nausea, vomiting, and abdominal pain. Excessive vitamin D intake from Cholecalciferol may lead to hypercalcemia, resulting in symptoms like muscle weakness, frequent urination, and kidney problems. It is important to promptly seek medical advice and treatment if an overdose is suspected, as early intervention can help manage these symptoms effectively.

  • Missed Dose

    In the case of a missed dose of Alendronate 70mg, take it as soon as you remember, but avoid taking it too close to your next scheduled dose. If it's almost time for your next dose, skip the missed one and continue with your regular schedule. For Cholecalciferol 70mcg Tablet, if a dose is missed, take it as soon as you remember, but if it's close to your next dose, skip the missed dose and continue with your regular dosing schedule. It's important not to double the dose to make up for a missed one.

  • How To Use

    To take Alendronate 70mg and Cholecalciferol 70mcg Tablet, swallow the tablet whole with a full glass of plain water first thing in the morning, at least 30 minutes before eating or drinking anything else, and remain upright without lying down for at least 30 minutes after taking the medication to ensure optimal absorption.

  • When Not to Use

    Following are the conditions/situations when Alendronate 70mg, Cholecalciferol 70mcg Tablet should not be taken:

    • Should not be taken by individuals with a known hypersensitivity or allergy to Alendronate, Cholecalciferol, or any of the tablet's components.
    • Not suitable for patients with certain esophageal disorders, such as difficulty swallowing or narrowing of the esophagus.
    • Contraindicated in patients with severe kidney disease or low blood calcium levels (hypocalcemia).
    • Should not be used by individuals who are unable to stand or sit upright for at least 30 minutes after taking the tablet.
    • Not recommended for patients with certain dental issues, such as jawbone problems or those who are planning dental surgery.
    • Avoid use in patients with a history of esophageal ulcers or inflammation (esophagitis).
    • Should not be taken by individuals who have had certain types of gastric surgery.
  • Side Effects

    The side effects of Alendronate 70mg, Cholecalciferol 70mcg Tablet may include:

    • Osteonecrosis of the jaw (a serious condition affecting the jawbone)
    • Esophageal ulcers or irritation
    • Difficulty swallowing
    • Nausea and vomiting
    • Abdominal pain
    • Bone, muscle, or joint pain
    • Flu-like symptoms (such as fever and muscle aches)
    • Skin rash or itching
  • Precautions & Warnings

    Here are the precautions and warnings for Alendronate 70mg, Cholecalciferol 70mcg Tablet:

    • Patients with a known allergy to alendronate or cholecalciferol should not take this medication.
    • This medication should be taken on an empty stomach, and patients should remain upright (sitting, standing, or walking) for at least 30 minutes after taking the tablet to reduce the risk of esophageal irritation.
    • Individuals with difficulty swallowing or digestive issues may be at higher risk of esophageal problems, so caution is advised.
    • It is important to ensure adequate vitamin D and calcium intake while taking this medication to support bone health.
    • Patients with kidney disease or low blood calcium levels should use this medication with caution and under medical supervision.
    • This medication may cause osteonecrosis of the jaw, especially in patients with dental issues or invasive dental procedures. Regular dental check-ups are recommended.
    • Pregnant and breastfeeding women should consult their doctor before taking this medication, as it may affect fetal development and pass into breast milk.
    • Patients should inform their healthcare provider about all medications they are currently taking to avoid potential drug interactions.
  • Drug Interactions

    Following are the drug interactions for Alendronate 70mg, Cholecalciferol 70mcg Tablet:

    • Concomitant use with other bisphosphonates or vitamin D analogs may lead to increased bone mineral density effects and potential hypercalcemia.
    • Antacids containing calcium, magnesium, or aluminum can reduce the absorption of Alendronate, so separate their administration by at least 30 minutes.
    • Thiazide diuretics may increase the risk of hypocalcemia, and monitoring of calcium levels is recommended.
    • Corticosteroids can decrease bone mineral density, and caution is advised when used with Alendronate.
    • Some medications like phenytoin, phenobarbital, and rifampin may reduce the effectiveness of vitamin D (Cholecalciferol).
    • Calcium supplements or calcium-rich foods should be taken at a different time of day to ensure optimal absorption of both Alendronate and calcium.
    • Certain medications affecting the gastrointestinal tract, such as proton pump inhibitors or H2 blockers, might alter the absorption of Alendronate.
  • Food Interactions

    Following are the food interactions for Alendronate 70mg and Cholecalciferol 70mcg Tablet:

    • Avoid excessive caffeine intake, as it may interfere with calcium absorption, potentially reducing the effectiveness of Cholecalciferol.
    • High-fiber foods like whole grains, legumes, and certain vegetables can decrease the absorption of Alendronate. Consume them at least 30 minutes after taking the medication.
    • Dairy products rich in calcium, such as milk, cheese, and yogurt, can bind with Alendronate, reducing its absorption. Avoid taking the medication with these foods.
    • Foods fortified with Vitamin D should be consumed with caution, as excessive intake combined with Cholecalciferol supplementation can lead to vitamin D toxicity.
    • Alcohol may negatively impact bone health and potentially interfere with the absorption of Alendronate and Cholecalciferol. It's advisable to limit alcohol consumption.
    • Maintain a balanced diet rich in fruits and vegetables to support overall bone health and ensure optimal nutrient absorption.
    • Avoid taking the medication with mineral-rich foods like spinach, rhubarb, and nuts, as they can interfere with Alendronate absorption.
    • Grapefruit and grapefruit juice may not have a direct interaction, but due to their effect on liver enzymes, they might influence the metabolism of certain medications. Consult your healthcare provider for personalized advice.
  • Storage/Disposal

    Alendronate 70mg and Cholecalciferol 70mcg tablets should be stored in a cool and dry place, preferably at room temperature (25°C/77°F). Keep the medication in its original container, tightly sealed, to maintain its integrity and protect it from moisture. Avoid exposing the tablets to direct sunlight or heat sources, as they can degrade the medication. It is crucial to dispose of any unused or expired tablets properly by following local guidelines or consulting a pharmacist. Do not flush or pour them into the drainage system. Keep the medication away from children and pets to prevent accidental ingestion. Always check the expiry date before use, and ensure the tablets are not damaged or discolored.

  • Quick Tips, if any

    Following are the quick tips for Alendronate 70mg, Cholecalciferol 70mcg Tablet:

    • Take the tablet first thing in the morning on an empty stomach with a full glass of water.
    • Stay upright for at least 30 minutes after taking the tablet to prevent irritation to the esophagus.
    • Avoid taking other medications or food for at least 30 minutes after taking the tablet.
    • Maintain good oral hygiene and schedule regular dental check-ups while using this medication.
    • Inform your doctor if you have any dental issues or undergo any dental procedures.
    • Do not lie down or recline immediately after taking the tablet.
    • Store the medication at room temperature, away from moisture and heat.
    • Do not share the medication with others, even if they have similar symptoms.

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