ALGAPHAN TAB

Paracetamol 120mg Tablet primarily exerts its analgesic and antipyretic effects through its active metabolite, which is believed to inhibit the synthesis of prostaglandins, particularly in the central nervous system. This inhibition occurs by blocking the cyclooxygenase (COX) enzyme, although paracetamol's selectivity for COX inhibition is not as pronounced as that of traditional non-steroidal anti-inflammatory drugs (NSAIDs). The reduction in prostaglandin synthesis is thought to decrease the sensitivity of pain receptors and the set point of the hypothalamic thermoregulatory center, thereby alleviating pain and reducing fever. Additionally, paracetamol may also modulate serotonin and endocannabinoid systems, contributing to its analgesic properties, but these mechanisms are less well understood compared to its impact on prostaglandin synthesis.

Analgesic/Antipyretic

Tablet

The following are the uses of Paracetamol 120mg Tablet:

• Used for relieving mild to moderate pain such as headaches, toothaches, and post-vaccination fever.
• Used to reduce fever and manage discomfort associated with colds and flu.
• Effective for easing menstrual cramps and providing temporary relief.
• Helps alleviate pain and inflammation in conditions like osteoarthritis.
• Can be used to lower a high temperature and ease aches in children, but dosage should be carefully determined by weight.
• Provides relief from discomfort after medical procedures or minor surgeries.
• Useful for managing chronic pain conditions under medical supervision.
• May be used as an alternative to NSAIDs for those with certain sensitivities or conditions.

In the case of an overdose of Paracetamol 120mg Tablets, it is important to recognize the signs and act promptly. Symptoms may include nausea, vomiting, abdominal pain, and potential liver damage. Seek medical assistance immediately if an overdose is suspected. Quick action can help prevent severe complications, as early treatment is crucial for managing the toxic effects and minimizing the potential harm caused by excessive paracetamol intake. Timely intervention can significantly improve the outcome.

In the case of a missed dose of Paracetamol 120mg Tablet, it is generally advised to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to safely resume your medication regimen. It is important to maintain a consistent dosing routine for optimal effectiveness and safety.

To take the Paracetamol 120mg Tablet, place the tablet on your tongue and swallow it with a glass of water, preferably with or after a meal, as directed by your healthcare professional, ensuring you follow the prescribed dosage and frequency for your specific condition.

Following are the conditions/situations when Paracetamol 120mg Tablet should not be taken:

• Do not take if you have a known allergy or hypersensitivity to paracetamol or any of the excipients in the tablet.
• Avoid if you have severe liver impairment or active liver disease, as paracetamol is primarily metabolized in the liver.
• Not recommended for individuals with severe kidney impairment, as the excretion of paracetamol and its metabolites may be affected.
• Should not be used in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, as paracetamol may cause hemolysis.
• Contraindicated in patients with acute alcohol intoxication or chronic alcohol abuse, as it may increase the risk of liver damage.
• Avoid prolonged use without medical supervision, as long-term use may lead to liver or kidney problems.
• Do not exceed the recommended dose, as an overdose of paracetamol can cause severe liver damage.
• Not suitable for individuals who have previously experienced a skin reaction or respiratory problems after taking paracetamol.

The side effects of Paracetamol 120mg Tablet may include:

• Skin rash or itching
• Nausea and vomiting
• Stomach pain
• Loss of appetite
• Dark-colored urine
• Jaundice (yellowing of the skin or eyes)
• Allergic reactions (e.g., hives, swelling)
• Liver damage (rare)

Following are the precautions and warnings for Paracetamol 120mg Tablet:

• Do not exceed the recommended dosage, as excessive use can lead to liver damage.
• Consult a healthcare professional before use if you have liver or kidney disease, as Paracetamol metabolism may be affected.
• Avoid long-term use without medical supervision, as prolonged use can increase the risk of side effects.
• Paracetamol may interact with other medications, so inform your doctor about all the medicines you are taking.
• Alcohol consumption should be avoided or limited while taking Paracetamol to prevent potential liver damage.
• This medication is generally safe for use during pregnancy and breastfeeding, but consult your doctor for personalized advice.
• If symptoms persist or worsen, seek medical attention immediately, as it may indicate an underlying condition.
• Keep out of reach of children to prevent accidental overdose.

Following are the drug interactions for Paracetamol 120mg Tablet:

• Paracetamol can interact with warfarin, a blood thinner, potentially reducing its effectiveness and increasing the risk of bleeding.
• When taken with other central nervous system (CNS) depressants like opioids or benzodiazepines, it may enhance their effects, leading to increased sedation and respiratory depression.
• The hepatotoxicity risk may increase when combined with other potentially liver-damaging medications, such as certain anticonvulsants or alcohol.
• Anticonvulsant medications may decrease paracetamol's effectiveness by inducing liver enzymes that metabolize it more quickly.
• Prolonged use with chloramphenicol, a type of antibiotic, may increase the risk of bone marrow suppression.
• It may reduce the effectiveness of antidiabetic medications, requiring closer monitoring of blood glucose levels.
• Paracetamol can affect the results of certain laboratory tests, including urine glucose tests, which may show false negatives.

Following are the food interactions for Paracetamol 120mg Tablet:

• Avoid excessive alcohol consumption while taking this medication, as it may increase the risk of liver damage, especially with long-term use.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Paracetamol, potentially leading to increased drug levels in the body.
• High-fat meals may slightly delay the absorption of Paracetamol, but it generally does not significantly impact its effectiveness.
• Caffeine-containing beverages like coffee and tea can enhance the pain-relieving effects of Paracetamol, but excessive caffeine intake should be avoided due to potential side effects.
• Spicy foods are not known to interact directly with Paracetamol, but they may irritate the stomach and exacerbate gastrointestinal side effects in some individuals.
• Avoid excessive consumption of foods high in vitamin K (e.g., leafy greens) while taking Paracetamol, as it may reduce the medication's anticoagulant effects if used for this purpose.
• Certain herbal supplements, such as St. John's Wort, may interact with Paracetamol's metabolism, potentially affecting its effectiveness and increasing the risk of side effects.
• Always consult your healthcare provider for specific dietary recommendations when taking Paracetamol, especially if you have any medical conditions or are taking other medications.

Paracetamol 120mg Tablets should be stored in a cool, dry location, ideally at room temperature, ensuring protection from direct sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid storage in hot environments like near stoves or inside bathrooms, as temperature fluctuations can impact the medication's effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult your pharmacist or healthcare professional for appropriate disposal methods. Keep the medication securely stored, out of children's reach, to prevent accidental consumption. This ensures the safety and efficacy of the medication throughout its shelf life.

Following are the quick tips for Paracetamol 120mg Tablet:

• Consult your doctor before use, especially if you have liver or kidney issues.
• Take the tablet as directed by your healthcare professional.
• Ensure you read the label for dosage instructions and do not exceed the recommended dose.
• Swallow the tablet with a full glass of water for easy swallowing.
• Avoid alcohol consumption while taking this medication.
• If you experience any allergic reactions or severe skin reactions, seek medical attention immediately.
• Store the tablets in a cool, dry place, away from direct sunlight.