Alphadex Balm

Alphadex Balm

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  • Generic Name DEXMEDETOMIDINE

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Dexmedetomidine, the active ingredient in the balm, acts as a highly selective alpha-2 adrenergic receptor agonist. When applied, it stimulates these receptors in the skin, leading to a decrease in sympathetic nervous system activity. This results in peripheral vasoconstriction, which can help reduce inflammation and provide a soothing effect. The balm's mechanism of action is focused on its ability to modulate the body's adrenergic response, promoting localized blood vessel constriction and potentially offering relief from various skin conditions or discomforts.

  • Ingredients

    DEXMEDETOMIDINE
  • Drug Class

    Alpha-2 adrenergic agonist.

  • Dosage Form

    Balm

  • Uses

    The following are the uses of DEXMEDETOMIDINE balm:

    • Used for providing sedation in intensive care settings, helping critically ill patients requiring mechanical ventilation to remain calm and comfortable.
    • Used for procedural sedation during non-intubated head and neck surgery, ensuring patient comfort during the procedure.
    • Used for sedation in awake fiberoptic intubation, facilitating the intubation process while keeping the patient relaxed.
    • Used for sedation during MRI scans, allowing patients to remain still and comfortable during the procedure.
    • Used for managing agitation and ensuring patient cooperation during various medical procedures.
    • Used for short-term sedation in critically ill patients, aiding in their overall management and care.
    • Used for facilitating diagnostic procedures by keeping patients relaxed and cooperative.
  • In case of Overdose

    In the case of an overdose of DEXMEDETOMIDINE, immediate medical intervention is necessary. Symptoms may include severe bradycardia, hypotension, and respiratory depression. Treatment should focus on supportive care, including maintaining an open airway, managing cardiovascular instability, and providing ventilation support if required. It is crucial to monitor vital signs and provide appropriate respiratory and cardiovascular support until the effects of the overdose subside.

  • Missed Dose

    In the case of a missed dose of DEXMEDETOMIDINE balm, it is important to act promptly. If you remember within a short time after the missed application, apply the balm as soon as possible. However, if a significant amount of time has passed, it is generally recommended to skip the missed dose and continue with the next scheduled application. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. Consult your healthcare professional if you have any concerns or if you miss multiple doses.

  • How To Use

    To administer the DEXMEDETOMIDINE balm, apply a thin layer to the affected area of the skin, gently massaging it in a circular motion until it is fully absorbed, following the prescribed dosage and application frequency provided by your healthcare professional.

  • When Not to Use

    Following are the conditions/situations when DEXMEDETOMIDINE balm should not be used:

    • Avoid using in individuals with a known hypersensitivity or allergy to dexmedetomidine or any of the ingredients in the balm.
    • Do not apply to open wounds, broken skin, or severely irritated skin.
    • Contraindicated in individuals with severe cardiovascular diseases, such as severe bradycardia or heart block.
    • Should not be used in patients with a history of Raynaud's phenomenon or severe peripheral vascular disease.
    • Avoid using in patients with respiratory depression or severe respiratory conditions.
    • Not recommended for individuals with severe kidney disease or those on dialysis.
    • Do not use in children or elderly patients without medical supervision, as they may be more sensitive to the effects.
    • Contraindicated during breastfeeding, as the effects on breastfed infants are unknown.
    • Do not apply to the face or mucous membranes.
    • Avoid using in patients with a history of severe skin reactions or skin disorders.
  • Side Effects

    The side effects of DEXMEDETOMIDINE balm may include:

    • Drowsiness or sedation
    • Bradycardia (slow heart rate)
    • Hypotension (low blood pressure)
    • Dry mouth
    • Nausea and vomiting
    • Dizziness or lightheadedness
    • Headache
    • Skin irritation or rash at the application site
  • Precautions & Warnings

    Following are the precautions and warnings for DEXMEDETOMIDINE balm:

    • Avoid contact with eyes and mucous membranes. In case of accidental contact, immediately flush with water.
    • Do not apply on broken or irritated skin. Seek medical attention if irritation persists.
    • This balm is for external use only. Do not ingest or apply to open wounds.
    • Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.
    • Discontinue use and consult a healthcare professional if you experience any unusual symptoms or allergic reactions.
    • Use with caution in individuals with a history of skin sensitivity or allergies. A patch test is recommended before widespread application.
    • Do not use if the seal is broken or the packaging appears tampered with. Check the expiration date before use.
    • Consult a healthcare provider if you have any underlying medical conditions or are taking other medications to ensure safe usage.
  • Drug Interactions

    Following are the drug interactions for DEXMEDETOMIDINE balm:

    • Dexmedetomidine may interact with other central nervous system depressants, such as opioids, benzodiazepines, or alcohol, leading to enhanced respiratory depression and sedation.
    • The effect of dexmedetomidine can be reduced by medications that stimulate the central nervous system, including stimulants and certain antidepressants.
    • Drugs that inhibit the CYP2A6 enzyme, like fluvoxamine, may increase dexmedetomidine plasma concentrations, requiring dose adjustments.
    • Dexmedetomidine can decrease blood pressure, and its effect may be potentiated when used with other antihypertensive medications.
    • Barbiturates can decrease the sedative effects of dexmedetomidine, requiring close monitoring during co-administration.
    • Co-administration with other alpha-2 adrenergic agonists may result in additive effects and potential overdose.
    • Drugs that prolong the QT interval, when used with dexmedetomidine, should be monitored due to the potential for QT prolongation.
    • Anticonvulsants may alter the pharmacokinetics of dexmedetomidine, requiring dosage adjustments.
  • Food Interactions

    Following are the food interactions to consider with Dexmedetomidine balm:

    • Avoid consuming grapefruit or grapefruit juice as it may interfere with the metabolism of Dexmedetomidine, potentially leading to increased blood levels and enhanced effects.
    • Alcohol consumption should be minimized or avoided as it can exaggerate the sedative and hypotensive effects of Dexmedetomidine, causing excessive drowsiness and a significant drop in blood pressure.
    • Caffeine-rich foods and beverages like coffee, tea, and energy drinks should be consumed with caution as Dexmedetomidine may enhance their stimulant effects, leading to increased heart rate and blood pressure.
    • Spicy foods can potentially interact with Dexmedetomidine, causing skin irritation or exacerbating any existing skin sensitivity, especially if applied near the application site.
    • Foods rich in tyramine, such as aged cheeses, cured meats, and certain types of beer, should be avoided as they may interact with Dexmedetomidine, potentially leading to increased blood pressure.
    • Avoid consuming large amounts of chocolate, as it contains compounds that can interact with Dexmedetomidine, affecting its metabolism and potentially causing increased side effects.
    • High-fat meals may delay the absorption of Dexmedetomidine, leading to a potential reduction in its effectiveness, so it is advisable to apply the balm at least 2 hours before or after such meals.
    • Always consult your healthcare provider for personalized advice regarding specific food interactions and their management.
  • Storage/Disposal

    DEXMEDETOMIDINE balm should be stored in a secure and controlled environment, specifically in a cool and dry place away from direct sunlight, heat, and moisture. It is crucial to keep the balm in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Always check the expiration date on the packaging to ensure the medication's effectiveness and safety. When it comes to disposal, do not flush or pour the balm down the drain or toilet; instead, consult your local pharmacist or healthcare provider for appropriate disposal guidelines. Keep the balm out of children's reach to prevent accidental exposure, as it is intended for external use only. Proper storage and disposal practices are essential to ensure the safety and efficacy of DEXMEDETOMIDINE balm.

  • Quick Tips, if any

    Following are the quick tips for DEXMEDETOMIDINE balm:

    • Wash your hands before and after applying the balm for hygiene and to avoid contamination.
    • Clean and dry the affected area before application for better absorption.
    • Apply a thin layer of the balm as directed by your healthcare professional.
    • Avoid applying the balm on broken or irritated skin.
    • Do not cover the treated area with bandages or tight clothing to allow it to breathe.
    • Store the balm at room temperature, away from direct sunlight and moisture.
    • Consult your healthcare provider if you experience any unusual side effects or if symptoms worsen.

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