Amanta 100mg Tablets

Amantadine sulphate 100mg tablets primarily act by inhibiting the M2 proton channel in the influenza A virus. This mechanism is crucial for the virus's replication process. By blocking the M2 channel, amantadine prevents the virus from effectively uncoating and releasing its genetic material into the host cell, thus inhibiting viral replication. Additionally, amantadine may have NMDA receptor antagonist properties, which can modulate glutamate neurotransmission in the brain, although this mechanism is less understood and may contribute to its other therapeutic effects.

Amantadine sulphate 100mg

Antiviral, Antiparkinsonian.

Tablet

The following are the uses of Amantadine sulphate 100mg Tablet:

• Used for treating Parkinson's disease to reduce stiffness, shakiness, and difficulty with movement.
• Used to alleviate symptoms of fatigue and muscle weakness in Multiple Sclerosis patients.
• Used for reducing flu symptoms and speeding up recovery when started within 48 hours of symptoms.
• Used for controlling extrapyramidal symptoms caused by certain antipsychotic medications.
• Used for managing dyskinesia associated with long-term levodopa therapy in Parkinson's patients.
• Used to improve mental alertness and reduce confusion in elderly patients.
• Used to treat drug-induced dystonia, a type of abnormal movement disorder.

In the case of an overdose of Amantadine sulphate 100mg Tablets, individuals may experience a range of symptoms. These can include severe nausea, vomiting, and gastrointestinal disturbances. Additionally, patients may exhibit neurological effects such as confusion, hallucinations, and seizures. It is important to promptly seek medical assistance if an overdose is suspected, as healthcare professionals can provide appropriate treatment and support to manage these adverse effects effectively.

In the case of a missed dose of Amantadine sulphate 100mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss several doses, consult your healthcare professional for advice on how to safely resume your medication regimen, as they may recommend adjusting the dosage or provide specific instructions for catching up on missed doses.

To take Amantadine sulphate 100mg Tablet, swallow the tablet whole with a full glass of water, preferably with or after a meal, once or twice a day as directed by your healthcare professional, ensuring you follow the prescribed dosage instructions.

Following are the conditions when Amantadine Sulfate 100mg Tablet should not be used:

• Should not be used in individuals with a known hypersensitivity or allergy to Amantadine or any of the tablet's components.
• Contraindicated in patients with untreated closed-angle glaucoma.
• Not recommended for individuals with severe kidney disease or kidney impairment.
• Should not be used in patients with severe liver disease or liver cirrhosis.
• Contraindicated during severe high blood pressure.

The side effects of Amantadine Sulfate 100mg Tablet may include:

• Nausea and vomiting
• Loss of appetite
• Dizziness or lightheadedness
• Insomnia
• Constipation or diarrhea
• Dry mouth
• Blurred vision or visual disturbances
• Confusion or hallucinations (more common in elderly patients)

Following are the precautions and warnings for Amantadine Sulfate 100mg Tablet:

• Amantadine should not be used in patients with severe kidney impairment or end-stage renal disease, as it can lead to accumulation of the drug and potential toxicity.
• Patients with a history of seizures or epilepsy should exercise caution, as Amantadine may lower the seizure threshold. Regular monitoring is necessary.
• This medication can cause drowsiness and dizziness, affecting the ability to drive or operate machinery. Avoid such activities until you know how the medication affects you.
• Amantadine may cause orthostatic hypotension, leading to dizziness or lightheadedness. Patients should rise slowly from a sitting or lying position to prevent falls.
• Elderly patients may be more sensitive to the effects of Amantadine, particularly the central nervous system effects. Lower initial doses are recommended.
• Amantadine can cause psychiatric symptoms such as confusion, hallucinations, and agitation. Patients should be monitored for these symptoms, especially those with a history of psychiatric disorders.
• Patients with a history of liver disease should be monitored regularly, as Amantadine is metabolized by the liver and may require dosage adjustments.
• This medication should be used with caution in individuals with a history of cardiovascular disease, as it may affect heart rate and blood pressure. Regular monitoring is advised.

Following are the drug interactions for Amantadine sulfate 100mg Tablet:

• Amantadine may increase the risk of anticholinergic side effects (e.g., dry mouth, blurred vision, constipation, urinary retention) when taken with other anticholinergic drugs (e.g., antihistamines, tricyclic antidepressants).
• The combination of Amantadine with other dopaminergic medications (e.g., levodopa, bromocriptine) may result in an increased risk of side effects like confusion, agitation, and hallucinations. Dose adjustments may be necessary.
• Amantadine can enhance the central nervous system (CNS) effects of other CNS stimulants (e.g., caffeine, methylphenidate), potentially leading to increased agitation, restlessness, or insomnia.
• Concurrent use with other medications that increase dopamine (e.g., monoamine oxidase inhibitors or MAOIs like phenelzine) may cause excessive dopaminergic effects, including severe hypertension, seizures, or agitation.
• Amantadine may interact with antiviral medications (e.g., rimantadine), leading to an increased risk of adverse effects or reduced effectiveness. Caution is advised when used with these drugs.
• The use of Amantadine with other medications that may cause QT interval prolongation (e.g., certain antipsychotics, antiarrhythmic drugs) should be monitored closely as this combination may increase the risk of arrhythmias.
• When used with other drugs that affect kidney function (e.g., diuretics, NSAIDs), Amantadine should be used with caution as renal impairment may lead to increased levels of the drug in the blood, raising the risk of toxicity.
• Amantadine may increase the sedative effects of other CNS depressants (e.g., alcohol, benzodiazepines), leading to excessive sedation or dizziness. Caution is advised when combining these medications.
• The combination of Amantadine with antihypertensive medications may increase the risk of hypotension (low blood pressure), requiring careful monitoring.

Following are the food interactions for Amantadine Sulfate 100mg Tablet:

• Amantadine may cause an increase in appetite, so be mindful of excessive calorie intake and opt for healthy, balanced meals.
• It is advisable to maintain a consistent and healthy diet as the medication can sometimes cause nausea and loss of appetite.
• Avoid consuming grapefruit or grapefruit juice as it may interfere with the medication's metabolism, potentially leading to increased side effects.
• Alcohol consumption should be limited as it can enhance the sedative effects of Amantadine, causing increased drowsiness and dizziness.
• Caffeine intake should be monitored as it may exacerbate certain side effects such as nervousness and insomnia, which are already potential side effects of the medication.
• There is no specific food restriction with Amantadine, but a healthy diet is recommended to maintain overall well-being.
• Always follow the dietary advice provided by your healthcare professional, especially if you have any specific health conditions or dietary restrictions.

Amantadine Sulphate 100mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area. Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. It is crucial to store the medication at room temperature, avoiding extreme heat or cold, as temperature fluctuations can impact its effectiveness. Do not transfer the tablets to a different container, as this may lead to confusion and potential misuse. Always check the expiration date before using any medication, and if the tablets have passed their expiry, dispose of them responsibly. Proper disposal methods include returning them to a pharmacy or following local guidelines for pharmaceutical waste disposal, ensuring they do not contaminate the environment or pose a risk to others.

Following are the quick tips for Amantadine Sulphate 100mg Tablet:

• Consult a doctor for the correct dosage and duration tailored to your medical condition.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Take the tablet with or after meals to minimize stomach irritation.
• Maintain a consistent schedule; if you miss a dose, take it as soon as you remember, unless it's close to your next dose.
• Do not double the dose to make up for a missed one; consult a doctor if you frequently miss doses.
• Inform your doctor about all medications you're taking to avoid potential drug interactions.
• Store the medication at room temperature, away from moisture and heat, and keep it out of children's reach.