AMINOMUX 30MG INJ

Pamidronate Disodium, when administered as a 30mg injection, primarily acts by inhibiting osteoclast-mediated bone resorption. It belongs to the class of bisphosphonates, which selectively bind to bone mineral, targeting active bone remodeling sites. By inhibiting osteoclast activity, Pamidronate Disodium reduces the breakdown of bone tissue, leading to a decrease in bone resorption and the release of calcium from bones into the bloodstream. This mechanism helps in the management of conditions characterized by excessive bone resorption, as it promotes a shift in the balance between bone formation and resorption, ultimately contributing to increased bone density and strength.

Bisphosphonate

injection

The following are the uses of Pamidronate Disodium 30mg injection:

• Used for treating hypercalcemia (high calcium levels in the blood) associated with certain types of cancer, such as multiple myeloma and breast cancer.
• Used for managing Paget's disease of bone, a condition where bones become weak and deformed.
• Used for reducing bone pain and preventing fractures in patients with advanced bone metastases.
• Used for treating osteolytic bone lesions caused by multiple myeloma.
• Used for managing hypercalcemia in patients with kidney failure or parathyroid-related disorders.
• Used for improving bone density and reducing fracture risk in certain bone-weakening conditions.
• Used for managing bone complications in patients undergoing bone marrow transplant or stem cell transplant.

In the case of an overdose of Pamidronate Disodium 30mg injection, the severity of symptoms may vary. Common signs include electrolyte imbalances, renal dysfunction, and severe bone, joint, or muscle pain. Immediate medical intervention is necessary, with treatment focused on managing symptoms and providing supportive care. Medical professionals should closely monitor vital signs and administer appropriate therapies to address specific complications. Prompt action is vital to minimize the potential long-term effects of an overdose.

In the case of a missed dose of Pamidronate Disodium 30mg injection, it is important to contact your healthcare provider for guidance. They will advise you on whether to administer the missed dose as soon as possible or simply wait until the next scheduled dose. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss a dose, inform your doctor and follow their instructions to ensure the best course of action for your specific treatment plan.

To administer Pamidronate Disodium 30mg injection, reconstitute the vial with the provided sterile diluent, gently swirl to dissolve, and then inject the entire contents intravenously over a period of 2 to 8 hours, ensuring slow infusion to minimize the risk of adverse effects.

Here are the situations or conditions when Pamidronate Disodium 30mg injection should not be administered:

• Should not be used in patients with known hypersensitivity or allergy to Pamidronate Disodium or any of its excipients.
• Contraindicated in patients with severe renal impairment (kidney disease) where creatinine clearance is less than 30 mL/min.
• Not recommended for patients with low blood calcium levels (hypocalcemia) as it may exacerbate the condition.
• Should not be used in patients with active or untreated vitamin D deficiency.
• Contraindicated during pregnancy as it may cause harm to the fetus.
• Not suitable for patients with severe bone, joint, or muscle pain, especially in the thigh or hip.
• Should be avoided in patients with severe dental problems or those who are undergoing dental surgery, as it may increase the risk of jaw-related side effects.
• Should not be used in patients with parathyroid gland disorders that are not well-controlled.

The side effects of Pamidronate Disodium 30mg injection may include:

• Fever or flu-like symptoms
• Pain at the injection site
• Nausea or vomiting
• Headache
• Dizziness or lightheadedness
• Muscle or joint pain
• Low calcium levels (hypocalcemia), leading to symptoms like muscle cramps, spasms, or tingling
• Weakness or fatigue
• Abdominal pain
• Dehydration or electrolyte imbalances
• Risk of osteonecrosis of the jaw (rare)
• Kidney problems, including renal dysfunction (rare, especially with high doses or prolonged use)
• Rash or skin reactions
• Difficulty swallowing or breathing (rare allergic reaction)

Following are the precautions and warnings for Pamidronate Disodium 30mg injection:

• Not recommended for patients with known hypersensitivity or allergy to Pamidronate Disodium or any of its excipients.
• Renal function should be assessed before administration, and caution should be exercised in patients with renal impairment as dosage adjustments may be necessary.
• Monitor for hypocalcemia during treatment and ensure adequate calcium and vitamin D intake.
• Avoid extravasation as it can cause severe local tissue damage. Ensure the needle is correctly positioned in the vein during infusion.
• Use with caution in patients with severe cardiac disorders, as it may worsen their condition.
• Elderly patients may be more susceptible to adverse effects; dosage adjustments might be required.
• Not recommended for use in pregnant or breastfeeding women unless the potential benefits outweigh the risks.
• Patients should be advised to seek medical attention if they experience any unusual symptoms or severe side effects during or after the infusion.

Following are the drug interactions for Pamidronate Disodium 30mg injection:

• Renal toxicity may be increased when used with other nephrotoxic drugs, such as aminoglycosides or nonsteroidal anti-inflammatory drugs (NSAIDs).
• Concomitant use with other bisphosphonates can increase the risk of hypocalcemia and other bone-related side effects.
• Pamidronate may reduce the efficacy of antineoplastic agents, as it can inhibit tumor cell adhesion and invasion.
• Calcium-containing solutions or products (e.g., calcium supplements, calcium-fortified juices) should be avoided within 24 hours of Pamidronate administration to prevent decreased absorption.
• The use of loop diuretics (e.g., furosemide) may increase the risk of renal toxicity when used with Pamidronate.
• Thiazide diuretics can decrease the excretion of Pamidronate, potentially leading to increased drug levels and toxicity.
• Caution is advised when using Pamidronate with other medications that affect bone metabolism, as it may alter the therapeutic response.

Following are the food interactions for Pamidronate Disodium 30mg injection:

• Avoid excessive caffeine intake as it may interfere with the calcium-regulating effects of Pamidronate, potentially affecting bone health.
• Maintain adequate calcium and vitamin D intake through diet or supplements as recommended by your healthcare provider.
• Ensure a balanced diet rich in fruits, vegetables, and whole grains to support overall health during treatment.
• Avoid high-sodium foods, as Pamidronate can impact sodium levels in the body.
• Stay well-hydrated, especially before and after the injection, to support kidney function.
• Limit alcohol consumption as it may affect bone metabolism and interact with the medication's effects.
• Avoid grapefruit and grapefruit juice as they can alter the metabolism of Pamidronate, potentially affecting its efficacy.
• Follow any dietary recommendations provided by your healthcare team, especially if you have kidney or bone-related conditions.

Pamidronate Disodium 30mg injection should be stored with careful handling in a controlled environment, preferably in a cool and dry place at room temperature, ensuring it remains between 15°C and 30°C. Protect the injection from direct sunlight, heat, and moisture, as these factors can degrade the medication. Always keep the medication in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. When disposing of unused or expired Pamidronate Disodium injection, do not throw it in the trash or pour it down the drain. Instead, contact your healthcare provider or pharmacist for instructions on safe disposal methods to ensure environmental responsibility. Keep the medication away from children and pets to prevent accidental exposure.

Following are the quick tips for Pamidronate Disodium 30mg injection:

• Ensure you receive this injection under medical supervision and as prescribed.
• Inform your doctor about your medical history and current medications.
• Stay well-hydrated before and after the injection to aid in the medication's effectiveness.
• Report any allergic reactions or severe side effects to your healthcare provider immediately.
• Avoid missing doses; maintain a consistent treatment schedule for best results.
• Store the medication properly and out of reach of children.
• Do not reuse needles; dispose of them safely after each injection.