Aminomux (90mg) 1 Vial Injection

Pamidronate Disodium's primary mechanism of action involves inhibiting osteoclast-mediated bone resorption. It binds to hydroxyapatite bone matrix, disrupting osteoclast activity and function. By selectively inhibiting osteoclasts, the medication reduces bone resorption, increases bone mineral density, and helps prevent bone loss. This action is particularly beneficial in conditions where excessive bone breakdown occurs, such as osteoporosis and Paget's disease.

Bisphosphonate

injection

The following are the uses of Pamidronate Disodium 90mg injection:

• Used for treating hypercalcemia, a condition of high calcium levels in the blood, often associated with cancer.
• Used for managing bone pain and fractures caused by bone metastases in cancer patients.
• Used for Paget's disease of bone, to reduce bone pain and prevent further bone damage.
• Used for treating osteoporosis, especially in postmenopausal women, to reduce the risk of bone fractures.
• Used for managing bone complications in patients with multiple myeloma.
• Used for preventing bone loss and fractures in immobilized patients or those with certain medical conditions.
• Used for treating osteogenesis imperfecta, a genetic bone disorder, to improve bone density and reduce fracture risk.

In the case of an overdose of Pamidronate Disodium 90mg injection, it is crucial to seek medical assistance promptly. Overdose symptoms may include severe bone, joint, or muscle pain, as well as gastrointestinal issues like nausea, vomiting, and diarrhea. Medical professionals should be informed about the amount ingested, and they may recommend immediate gastric lavage or provide supportive care to manage symptoms and prevent further complications.

In the case of a missed dose of Pamidronate Disodium 90mg injection, it is important to contact your healthcare provider for guidance. They will advise you on whether to administer the missed dose as soon as possible or if it is safer to simply wait until the next scheduled dose. Do not double the dose to make up for a missed one unless specifically instructed to do so by your healthcare provider. It is crucial to maintain a consistent dosing schedule for this medication, so try to take it at the same time each day.

To administer Pamidronate Disodium 90mg injection, reconstitute the powder with the provided sterile diluent, gently swirl the vial to ensure complete dissolution, and withdraw the medication into a syringe, then inject it slowly into the intravenous infusion bag, ensuring the entire dose is delivered over a period of 2 to 24 hours as directed by your healthcare professional.

Following are the conditions/situations when Pamidronate Disodium 90mg injection should not be administered:

• Should not be used in patients with known hypersensitivity or allergy to Pamidronate Disodium or any of its excipients.
• Contraindicated in patients with severe renal impairment (kidney failure) or those receiving dialysis.
• Not recommended for individuals with low blood calcium levels (hypocalcemia).
• Should not be used during pregnancy or in breastfeeding women.
• Not suitable for patients with active dental issues or those undergoing dental procedures.
• Contraindicated in patients with severe bone, joint, or muscle pain.
• Should not be administered if the patient has a history of severe gastrointestinal disorders.

The side effects of Pamidronate Disodium 90mg injection may include:

• Fever and flu-like symptoms
• Bone pain
• Nausea and vomiting
• Fatigue and weakness
• Low blood pressure
• Kidney impairment
• Muscle cramps
• Joint pain

Following are the precautions and warnings for Pamidronate Disodium 90mg injection:

• This medication should not be administered to patients with known hypersensitivity or allergy to Pamidronate Disodium or any of its excipients.
• Kidney function should be closely monitored during treatment, as Pamidronate Disodium can cause renal impairment.
• Caution is advised in patients with pre-existing kidney disease, as dosage adjustments may be necessary.
• It is recommended to maintain adequate hydration before and after the injection to reduce the risk of kidney damage.
• Patients should be closely monitored for hypocalcemia (low calcium levels) and appropriate measures should be taken to manage it.
• Avoid extravasation (leakage outside the vein) during infusion as it may lead to tissue damage.
• Pregnant and breastfeeding women should consult their doctor before using this medication, as it may have potential risks to the fetus or infant.
• Patients with a history of recent dental surgery or dental disorders should inform their healthcare provider before treatment.

Following are the drug interactions for Pamidronate Disodium 90mg injection:

• Renal toxicity can be increased when used with other nephrotoxic drugs like aminoglycosides, amphotericin B, or nonsteroidal anti-inflammatory drugs (NSAIDs).
• Concomitant use with diuretics, especially loop diuretics, may increase the risk of renal impairment.
• The risk of hypocalcemia may be elevated when used with other drugs that lower calcium levels, such as certain anticonvulsants (e.g., phenytoin, phenobarbital) or corticosteroids.
• Pamidronate can decrease the absorption of oral medications like iron, zinc, or calcium supplements, so separate administration by at least 2 hours.
• Thrombocytopenia risk may be increased when used with other drugs known to affect platelet function, such as heparin or clopidogrel.
• May reduce the efficacy of vaccines, especially live attenuated vaccines, when administered concurrently.
• Use with caution in patients taking antineoplastic agents, as it may increase the risk of bone pain and other skeletal complications.

Following are the food interactions for Pamidronate Disodium 90mg injection:

• Avoid consuming calcium-rich foods like dairy products (milk, cheese, yogurt), calcium-fortified foods, and calcium supplements within 48 hours of the injection, as Pamidronate can decrease calcium absorption.
• Maintain adequate hydration before and after the injection, ensuring you drink plenty of fluids, preferably water, to reduce the risk of kidney damage.
• Avoid alcohol consumption, as it can increase the risk of kidney problems and may also interact with the medication, affecting its effectiveness.
• Grapefruit and grapefruit juice should be avoided, as they may interfere with the metabolism of the medication, potentially increasing its levels in the blood.
• Avoid high-sodium foods and beverages, as Pamidronate can increase sodium levels in the blood, especially in patients with kidney impairment.
• There is no specific food interaction with Pamidronate Disodium injection, but it is generally recommended to maintain a balanced diet to support overall health during treatment.
• Consult your healthcare provider for personalized dietary advice, especially if you have any specific dietary restrictions or medical conditions.

Pamidronate Disodium 90mg injection should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 20°C and 25°C (68°F to 77°F). Protect the injection from direct sunlight, as exposure to light can degrade its potency. Store it in its original packaging, ensuring the container is tightly sealed to maintain sterility. It is crucial not to freeze the injection, as this can alter its composition. Always check the expiration date before use, and dispose of any unused or expired medication responsibly. When disposing of the injection, do not discard it in regular household trash or pour it down the drain. Instead, contact your local waste management authority or healthcare provider for guidance on safe disposal methods to minimize environmental impact. Keep the medication out of reach of children and pets to prevent accidental exposure.

Following are the quick tips for Pamidronate Disodium 90mg injection:

• Follow your doctor's instructions for the injection procedure and dosage.
• Ensure the injection is administered by a healthcare professional.
• Stay well-hydrated before and after the injection.
• Inform your doctor about any allergies or medical conditions.
• Avoid alcohol and maintain a healthy diet during treatment.
• Report any side effects or unusual symptoms immediately.
• Store the injection as directed, away from direct sunlight and moisture.
• Do not reuse needles or syringes; dispose of them safely.