Amotac (10mg) 20 Tablets

Azathioprine primarily exerts its immunosuppressive effects through the metabolism of its active metabolites. After ingestion, azathioprine is rapidly converted to 6-mercaptopurine (6-MP) in the body. 6-MP is further metabolized through two main pathways. Firstly, it can be converted to thioinosine monophosphate (TIMP), which inhibits the enzyme purine nucleoside phosphorylase, leading to reduced lymphocyte proliferation. Secondly, 6-MP can be converted to 6-thioguanine nucleotides (6-TGN), which interfere with DNA synthesis and repair, causing cytotoxic effects on rapidly dividing cells, including immune cells. This dual mechanism of action contributes to the overall immunosuppressive effect of azathioprine, making it useful in managing autoimmune diseases and preventing organ rejection in transplant patients.

Immunosuppressant

Tablet

The following are the uses of Azathioprine 10mg Tablet:

• Used for suppressing the immune system and treating autoimmune diseases like rheumatoid arthritis and lupus.
• Used for preventing organ rejection in transplant patients.
• Used for managing inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
• Used for treating severe skin conditions like eczema and psoriasis.
• Used for managing autoimmune hepatitis and other liver disorders.
• Used for reducing inflammation in conditions like vasculitis and myositis.
• Used for controlling symptoms of certain blood disorders, such as autoimmune hemolytic anemia.
• Used for supporting the management of rare autoimmune conditions as advised by specialists.

In the case of an overdose of Azathioprine 10mg Tablets, it is crucial to recognize the potential severity of this situation. The effects of an overdose may include severe suppression of the immune system, leading to increased susceptibility to infections. Additionally, gastrointestinal symptoms such as nausea, vomiting, and diarrhea may occur. Prompt medical intervention is essential, including contacting a healthcare professional or a poison control center for guidance on managing the overdose and providing appropriate treatment.

In the case of a missed dose of Azathioprine 10mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses or are unsure about how to manage missed doses, contact your healthcare provider for guidance. They can provide specific instructions based on your medical condition and treatment plan.

To take Azathioprine 10mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions or situations when Azathioprine 10mg Tablet should not be used:

• Must not be taken if you are allergic to azathioprine or any other similar medications.
• Contraindicated in individuals with a severe bone marrow depression.
• Avoid using if you have an active infection as it can worsen the condition.
• Not recommended for individuals with a known deficiency of the enzyme thiopurine methyltransferase (TPMT).
• Should not be used during pregnancy or breastfeeding without medical advice.
• Do not take if you have liver or kidney disease without consulting a doctor.

The side effects of Azathioprine 10mg Tablet may include:

• Nausea and vomiting
• Loss of appetite
• Fatigue and weakness
• Diarrhea
• Skin rashes or itching
• Hair loss
• Increased risk of infections
• Liver problems

Following are the precautions and warnings for Azathioprine 10mg Tablet:

• This medication is not recommended for individuals with known hypersensitivity or severe allergic reactions to Azathioprine or any of its ingredients.
• Regular blood tests are required to monitor blood cell counts and liver function due to the potential for bone marrow suppression and liver toxicity.
• Patients with a history of kidney or liver disease should exercise caution and consult their doctor, as Azathioprine is primarily metabolized in these organs.
• Azathioprine may increase the risk of developing certain types of cancer, especially skin cancer. Regular skin examinations are recommended.
• Avoid exposure to sunlight or UV rays, and use protective measures when outdoors.
• Inform your doctor if you have any infections, as Azathioprine can increase the risk of severe infections and may mask their symptoms.
• Women of childbearing age should use effective contraception while on this medication, as it can cause birth defects if used during pregnancy.
• Breastfeeding is not recommended while taking Azathioprine due to potential risks to the infant.

Following are the drug interactions for Azathioprine 10mg Tablet:

• Azathioprine may interact with other immunosuppressants like ciclosporin, increasing the risk of infections and suppressing bone marrow function.
• The risk of bone marrow suppression and severe infections can be heightened when combined with tumor necrosis factor (TNF) inhibitors such as etanercept or infliximab.
• Allopurinol can significantly increase the levels of Azathioprine, leading to enhanced toxicity. Dose adjustments may be necessary.
• When taken with ACE inhibitors like captopril, Azathioprine may increase the risk of bone marrow suppression and infections.
• Azathioprine can decrease the effectiveness of live vaccines, and live vaccines may cause infections in individuals taking this medication.
• This drug may interact with mycophenolate mofetil, potentially increasing the risk of side effects related to bone marrow suppression.
• Concomitant use with sulfonamides may increase the risk of skin reactions and other side effects.
• Azathioprine may interact with certain antibiotics, affecting their metabolism and potentially leading to increased side effects.

Following are the food interactions for Azathioprine 10mg Tablet:

• Alcohol consumption should be limited as it can increase the risk of liver problems and may interfere with the medication's effectiveness.
• Grapefruit and grapefruit juice should be avoided as they can affect the metabolism of Azathioprine, leading to increased drug levels in the body.
• High-fat meals may slightly decrease the absorption of Azathioprine, so it is best to take the medication on an empty stomach or with a light meal.
• Avoid black elderberry as it may decrease the effectiveness of Azathioprine by stimulating the immune system.
• Green tea and green tea extracts might reduce the therapeutic effect of Azathioprine due to their potential immune-boosting properties.
• Garlic supplements may increase the risk of bleeding when taken with Azathioprine, so consult your doctor before using them.
• Avoid St. John's Wort as it can reduce the levels of Azathioprine in the body, making the medication less effective.
• Consult your doctor or pharmacist if you have a diet rich in purines (found in organ meats, anchovies, and certain beans) as Azathioprine may increase uric acid levels.

Azathioprine 10mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight, moisture, and heat. The original container should be used to keep the tablets, ensuring a tight seal to maintain their integrity. It is crucial not to store the medication in bathrooms or near heat-emitting appliances to prevent degradation. Regularly check the expiration date, and if the tablets are no longer needed or have expired, proper disposal is essential. Avoid flushing them down the toilet or sink; instead, consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Azathioprine 10mg Tablet:

• Consult your doctor before starting this medication and provide a detailed medical history.
• Take the tablet as directed by your doctor, typically once or twice daily.
• Consume the tablet whole with a full glass of water; do not crush or chew.
• Maintain a consistent medication schedule; take it at the same time each day.
• Do not stop taking the medication abruptly without medical advice.
• Regular blood tests may be required to monitor your progress and adjust dosage.
• Inform your doctor about all medications you're taking to prevent interactions.