Amoxi-Clav (500/125mg) 6 Tablets

Co-Amoxiclav 625mg Tablet is a combination antibiotic that contains amoxicillin and clavulanic acid. Amoxicillin belongs to the penicillin group of antibiotics and works by inhibiting the synthesis of bacterial cell walls. It specifically targets the penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan strands in the bacterial cell wall. This interference weakens the cell wall, leading to cell lysis and bacterial death. Clavulanic acid, on the other hand, is a beta-lactamase inhibitor. It protects amoxicillin from being broken down by bacterial enzymes called beta-lactamases, which some bacteria produce as a defense mechanism. By inhibiting beta-lactamase, clavulanic acid extends the spectrum of activity of amoxicillin, making it effective against a wider range of bacteria, including those that produce beta-lactamase and would otherwise be resistant to amoxicillin alone.

Co-Amoxiclav 625mg

Antibiotic.

Tablet

The following are the uses of Co-Amoxiclav 625mg Tablet:

• Used for treating severe bacterial infections such as pneumonia, skin and soft tissue infections, and urinary tract infections.
• Used to combat bacterial infections that are resistant to regular antibiotics.
• Used in cases of acute bacterial sinusitis, effectively clearing the infection.
• Used for the treatment of acute flare-ups of chronic bronchitis, reducing symptoms and bacterial presence.
• Used to address middle ear infections, providing relief and eliminating the bacteria causing the infection.
• Used for certain types of dental infections, aiding in reducing pain and inflammation.
• Used as a prophylactic measure to prevent infections in high-risk situations, such as before surgeries or for patients with weakened immune systems.

To be used as per doctor's prescription

In the case of an overdose of Co-Amoxiclav 625mg Tablets, immediate medical attention is necessary. Symptoms may include nausea, vomiting, diarrhea, and skin rashes. The severity of these symptoms can vary based on the amount ingested. It is crucial to seek medical help promptly, as overdoses can lead to potential complications, particularly in individuals with kidney or liver issues. Prompt action ensures the best possible outcome in such situations.

In the case of a missed dose of Co-Amoxiclav 625mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you have missed multiple doses, consult your healthcare provider for further guidance, as they may recommend adjusting your dosage or provide specific instructions to ensure you receive the full benefits of the medication.

To take Co-Amoxiclav 625mg Tablet, swallow the tablet whole with a full glass of water, ensuring you complete the full course as prescribed by your healthcare provider, typically taken every 8 hours or as directed.

Here are the conditions or situations when Co-Amoxiclav 625mg Tablet should not be taken:

• Avoid if you are allergic to any penicillin antibiotic or beta-lactamase inhibitors.
• Do not use if you have a history of severe allergic reactions (anaphylaxis) to any other beta-lactam antibiotics.
• Contraindicated in patients with a previous history of liver problems or jaundice associated with amoxicillin/clavulanic acid use.
• Should not be used if you have severe kidney disease.
• Avoid if you have mononucleosis.
• Not suitable for individuals with a history of gastrointestinal diseases, especially colitis or any other inflammatory bowel disease.
• Do not take if you have recently received or are about to receive a live vaccine.

The side effects of Co-Amoxiclav 625mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Skin rash or itching
• Fatigue or drowsiness
• Headache
• Vaginal itching or discharge
• Allergic reactions (such as hives, swelling, or difficulty breathing)
• Liver problems (jaundice, dark urine)

Following are the precautions and warnings for Co-Amoxiclav 625mg Tablet:

• Do not take if you have a known allergy to penicillin antibiotics or any other ingredients in the tablet.
• Inform your doctor about any previous allergic reactions to antibiotics, especially if you have experienced severe reactions like anaphylaxis.
• Caution is advised for patients with kidney or liver problems, as dosage adjustments may be necessary.
• Prolonged use may lead to an increased risk of superinfections, such as oral or vaginal candidiasis.
• Co-Amoxiclav may reduce the effectiveness of contraceptive pills, so additional contraceptive measures are recommended.
• This medication should be used with caution in elderly patients, as they may be more susceptible to side effects.
• Always complete the full course of antibiotics as prescribed, even if you feel better before finishing the medication.

Following are the drug interactions for Co-Amoxiclav 625mg Tablet:

• Probenecid and allopurinol may reduce the elimination of amoxicillin, increasing the risk of side effects.
• Co-amoxiclav can reduce the effectiveness of oral contraceptives, requiring alternative birth control methods.
• Concurrent use with anticoagulants like warfarin may increase bleeding risk, requiring close monitoring.
• The risk of kidney damage may be elevated when used with cyclosporine.
• Methotrexate levels can be increased, potentially raising the risk of methotrexate toxicity.
• Live bacterial vaccines may be affected, leading to reduced vaccine efficacy.
• The effectiveness of mycophenolate may be reduced when taken with Co-amoxiclav.

Following are the food interactions for Co-Amoxiclav 625mg Tablet:

• Avoid excessive alcohol consumption while taking this medication as it may increase the risk of liver problems and stomach irritation.
• Limit or avoid grapefruit and grapefruit juice as they can affect the metabolism of the drug, leading to increased levels of the antibiotic in the body.
• Dairy products like milk, yogurt, and cheese may reduce the absorption of amoxiclav, so it is best to separate their intake by a few hours.
• Consuming high-fat meals may delay the absorption of the medication, so it is advisable to take the tablet before or after meals.
• Avoid vitamin C supplements or foods rich in vitamin C around the time of medication intake as they can potentially interfere with the antibiotic's effectiveness.
• Do not consume any iron-rich foods or supplements simultaneously as they can decrease the absorption of the medication.
• Certain beverages like tea and coffee may hinder the absorption of amoxiclav, so it's best to avoid them around the time of medication intake.
• Follow the dosage instructions provided by your healthcare professional to ensure the medication's effectiveness.

Co-Amoxiclav 625mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring it remains protected from direct sunlight and moisture. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent exposure to external contaminants. It is crucial not to store them in the bathroom or near heat-emitting appliances, as temperature fluctuations can impact their effectiveness. Dispose of any unused or expired tablets responsibly; do not flush them or pour them down the drain. Consult your pharmacist or healthcare professional for appropriate disposal methods, and always keep medications out of children's reach to prevent accidental ingestion. Proper storage and disposal are essential for safety and environmental considerations.

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Following are the quick tips for Co-Amoxiclav 625mg Tablet:

• Always take the tablet as directed by your doctor.
• Ensure you complete the full course of medication, even if you feel better.
• Take the tablet with a full glass of water to aid swallowing.
• It can be taken with or without food, but taking it with food may reduce stomach upset.
• Avoid crushing or chewing the tablet; swallow it whole.
• Store the medication in a cool, dry place, away from sunlight and moisture.
• Regularly monitor your health and inform your doctor of any persistent side effects.