Amsart-H 5/160/25mg

The combination of Hydrochlorothiazide 25mg, Amlodipine 5mg, and Valsartan 160mg in a single tablet exhibits a synergistic effect in treating hypertension. Hydrochlorothiazide acts as a diuretic, promoting the excretion of sodium and water, which helps to lower blood volume and reduce blood pressure. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into smooth muscle cells, leading to vasodilation and decreased peripheral resistance. Valsartan, an angiotensin II receptor blocker, competitively blocks the angiotensin II type 1 receptor, resulting in relaxation of blood vessels and reduced blood pressure by inhibiting the potent vasoconstrictive effects of angiotensin II. Together, these mechanisms effectively lower blood pressure by targeting different pathways involved in hypertension.

Hydrochlorothiazide 25mg, Amlodipine 5mg, valsartan 160mg

Angiotensin II Receptor Blocker, Calcium Channel Blocker, Diuretic

Tablet

The following are the uses of Hydrochlorothiazide 25mg, Amlodipine 5mg, valsartan 160mg Tablet:

• Used for managing high blood pressure, helping to lower and control hypertension.
• Used for treating hypertension-related conditions, including heart disease and kidney problems.
• Used for reducing fluid retention and swelling, particularly in cases of heart or kidney issues.
• Used for improving blood flow and relaxing blood vessels, aiding in overall cardiovascular health.
• Used for preventing complications associated with high blood pressure, such as stroke and heart attack.
• Used for regulating blood pressure in patients with a history of hypertension.
• Used for long-term management of blood pressure and cardiovascular health.

In the case of an overdose of Hydrochlorothiazide 25mg, Amlodipine 5mg, and valsartan 160mg tablets, individuals may experience symptoms such as excessive urination, dizziness, and a significant drop in blood pressure. This can lead to hypotension, causing lightheadedness and potential fainting. Other possible effects include an irregular heartbeat, electrolyte imbalances, and in severe cases, kidney dysfunction. Prompt medical intervention is essential to manage these symptoms and prevent further complications, especially if multiple medications are involved in the overdose.

In the case of a missed dose of Hydrochlorothiazide 25mg, it is generally recommended to take the missed dose as soon as you remember, unless it is close to the time for your next scheduled dose. If it is almost time for your next dose, skip the missed one and continue with your regular dosing schedule. For Amlodipine 5mg, if a dose is missed, take it as soon as you remember, but if it is close to the time for your next dose, skip the missed dose and proceed with the regular schedule. In the event of a missed dose of valsartan 160mg, take the missed dose as soon as possible, but if it is near the time for the next dose, it is advisable to skip the missed dose and maintain the regular dosing routine.

To take the combination tablet containing Hydrochlorothiazide 25mg, Amlodipine 5mg, and Valsartan 160mg, swallow the tablet whole with a glass of water, preferably at the same time each day, as directed by your healthcare provider. It is important to follow the prescribed dosage and not break or chew the tablet to ensure the medication's effectiveness.

Following are the conditions/situations when Hydrochlorothiazide 25mg, Amlodipine 5mg, and Valsartan 160mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to any of the active ingredients Hydrochlorothiazide, Amlodipine, or Valsartan.
• Contraindicated in patients with a history of angioedema (swelling under the skin) induced by previous use of ACE inhibitors or Amlodipine.
• Not suitable for individuals with severe renal impairment or patients with a history of diabetic nephropathy.
• Should not be used in patients with severe hepatic impairment.
• Contraindicated during pregnancy or breastfeeding.
• Avoid in patients with severe hypotension (low blood pressure).
• Not recommended for individuals with obstructive jaundice or biliary cirrhosis.

The side effects of Hydrochlorothiazide 25mg, Amlodipine 5mg, and Valsartan 160mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Nausea and vomiting
• Increased sensitivity to sunlight
• Skin rash or itching
• Muscle cramps
• Swelling in the legs or ankles

Following are the precautions and warnings for Hydrochlorothiazide 25mg, Amlodipine 5mg, and Valsartan 160mg Tablet:

• Individuals with known allergies to any of the components, including hydrochlorothiazide, amlodipine, or valsartan, should not take this medication.
• This medication may cause dizziness; patients should be cautious when performing tasks that require alertness, such as driving or operating heavy machinery.
• Regular monitoring of kidney function is necessary, especially in patients with pre-existing kidney problems, as these drugs can affect renal function.
• Electrolyte levels should be monitored, and patients should be aware of the risk of electrolyte imbalances, particularly in hot weather or during intense exercise.
• Patients with liver disease should exercise caution, as amlodipine is metabolized by the liver, and its effects may be altered.
• Valsartan may cause fetal harm; pregnant women should not take this medication, and effective birth control methods should be used.
• Breastfeeding women should consult their healthcare provider, as these drugs may pass into breast milk.
• Elderly patients may be more sensitive to the effects of these medications, particularly with blood pressure changes, and should be monitored closely.

Following are the drug interactions for Hydrochlorothiazide 25mg, Amlodipine 5mg, and Valsartan 160mg Tablet:

• Lithium levels can be increased, leading to lithium toxicity. Close monitoring of lithium levels is necessary.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the blood pressure-lowering effect and worsen kidney function.
• Antidiabetic medications (e.g., insulin, sulfonylureas) may have their effects enhanced, potentially causing hypoglycemia.
• The risk of angioedema may be increased when combined with ACE inhibitors.
• Hypokalemia may be exacerbated when used with corticosteroids or other potassium-depleting agents.
• The antihypertensive effect may be reduced when taken with non-potassium-sparing diuretics.
• The bioavailability of valsartan may be decreased when taken with antacids containing aluminum and magnesium hydroxide.

Following are the food interactions for Hydrochlorothiazide 25mg, Amlodipine 5mg, and Valsartan 160mg Tablet:

• Avoid excessive salt intake (sodium) as Hydrochlorothiazide is a diuretic and can increase sodium loss. Consuming high-salt foods may reduce the medication's effectiveness.
• Potassium-rich foods like bananas, oranges, and spinach are essential as Hydrochlorothiazide can cause potassium loss.
• Limit alcohol consumption as Amlodipine may increase its effects, leading to dizziness and low blood pressure.
• Grapefruit and grapefruit juice should be avoided with Valsartan, as they can increase the drug's blood levels, potentially causing an increased risk of side effects.
• Maintain a balanced diet; avoid high-fat meals, as they can affect the absorption of these medications.
• Stay hydrated, but avoid excessive fluid intake, as Hydrochlorothiazide may increase urination frequency.
• No significant food interactions are reported to directly impact the absorption of these medications, but it's best to follow healthcare provider guidelines.

Hydrochlorothiazide 25mg, Amlodipine 5mg, and Valsartan 160mg tablets should be stored in a cool, dry place, preferably at room temperature, away from direct sunlight and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing the tablets to high temperatures or humidity, such as in the bathroom or near kitchen appliances, as this can degrade their quality. Always check the expiration date, and if the medication is no longer needed or has expired, proper disposal is crucial. Do not flush or pour the medication down the drain; instead, consult a pharmacist or healthcare professional for safe disposal options. Ensure that the tablets are kept securely away from children to prevent accidental consumption.

Following are the quick tips for Hydrochlorothiazide 25mg, Amlodipine 5mg, and Valsartan 160mg Tablet:

• Always take the medication as directed by your doctor; do not alter the dosage without medical advice.
• Ensure you stay well-hydrated while taking these tablets.
• Take the tablet at the same time each day to maintain a consistent routine.
• Avoid taking with citrus juices as they may interfere with absorption.
• Store the medication in a cool, dry place, away from direct sunlight.
• Inform your doctor about all other medications you are taking to prevent potential interactions.
• Regularly monitor your blood pressure and kidney function while on this medication.