ANAXERYL OINT

The combined mechanism of action of Dithranol 0.35% w/w, Ichthammol 0.85% w/w, Resorcinol 0.002%, and Salicylic Acid 0.3% w/w Ointment is as follows Dithranol is the primary active ingredient and is known for its antipsoriatic properties. It works by inhibiting DNA synthesis and mitotic activity in the skin, slowing down the rapid cell division and growth associated with psoriasis. Ichthammol, derived from shale rocks, has anti-inflammatory and keratolytic effects, helping to reduce skin inflammation and break down thick scales. Resorcinol acts as a keratolytic agent, promoting the shedding of dead skin cells and reducing the thickness of psoriatic plaques. It also has mild antiseptic properties. Salicylic acid, another keratolytic agent, helps to soften and remove the scales and hyperkeratotic lesions associated with psoriasis. It enhances the penetration of other ingredients into the skin and has anti-inflammatory properties, further contributing to reducing skin inflammation and irritation. Together, these components work synergistically to alleviate the symptoms of psoriasis by regulating cell proliferation, reducing inflammation, and promoting the shedding of excess skin cells.

Topical anti-psoriatic agents.

Ointment

The following are the uses of Dithranol 0.35%w/w, Ichthammol 0.85%w/w, Resorcinol 0.002, Salicylic Acid 0.3%w/w Ointment:

• Used for the treatment of psoriasis, helping to slow down the growth of skin cells and reducing inflammation.
• Used to soothe and relieve skin irritation, itching, and inflammation caused by various skin conditions.
• Used for its keratolytic properties, aiding in the softening and removal of hard, scaly skin lesions.
• Used for its ability to treat a range of skin disorders, particularly those with hyperkeratosis.
• Used for managing chronic eczema and other skin conditions by reducing symptoms and promoting healing.
• Used for its antiseptic and anti-inflammatory properties, providing relief for minor skin infections.
• Used in the treatment of seborrheic dermatitis, helping to control symptoms and manage flare-ups.
• Used to promote the shedding of dead skin cells and improve skin texture in various dermatological conditions.

In the case of an overdose of Dithranol 0.35%w/w, Ichthammol 0.85%w/w, Resorcinol 0.002, and Salicylic Acid 0.3%w/w Ointment, the primary concern is potential skin irritation and allergic reactions. Symptoms may include severe redness, itching, blistering, or swelling at the application site. In the event of an overdose, promptly wash the affected area with mild soap and water to remove the excess ointment. Seek medical advice if symptoms persist or worsen, especially if there is difficulty breathing or swallowing.

In the case of a missed dose of Dithranol 0.35% w/w, Ichthammol 0.85% w/w, Resorcinol 0.002, and Salicylic Acid 0.3% w/w Ointment, it is recommended to apply the medication as soon as you remember. If it is close to the time for your next application, skip the missed dose and continue with your regular schedule. Do not apply extra ointment to make up for the missed dose, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for further guidance on adjusting your treatment plan.

To apply the Dithranol 0.35%w/w, Ichthammol 0.85%w/w, Resorcinol 0.002, Salicylic Acid 0.3%w/w Ointment, gently clean and dry the affected area, then apply a thin layer of the ointment, covering the skin completely, and repeat this process as directed by your healthcare provider, typically once or twice daily.

Following are the conditions/situations when Dithranol 0.35%w/w, Ichthammol 0.85%w/w, Resorcinol 0.002, Salicylic Acid 0.3%w/w Ointment should not be used:

• Avoid using this ointment if you have a known allergy or sensitivity to any of its ingredients, including Dithranol, Ichthammol, Resorcinol, or Salicylic Acid.
• Do not apply to broken or severely damaged skin, open wounds, or areas affected by eczema or other skin conditions without consulting a healthcare professional.
• Should not be used on mucous membranes or in the eyes.
• Avoid using this ointment on children without medical supervision.
• Discontinue use and consult a doctor if skin irritation, redness, or severe burning sensation occurs at the application site.
• Do not use this ointment if you are taking medications that may interact with its components, such as anticoagulants or medications affecting the skin's sensitivity to sunlight.
• Not recommended for individuals with a history of photosensitivity reactions.

The side effects of Dithranol 0.35%w/w, Ichthammol 0.85%w/w, Resorcinol 0.002, Salicylic Acid 0.3%w/w Ointment may include:

• Skin irritation or redness at the application site
• Burning or stinging sensation
• Itching or rash
• Dryness or peeling of the skin
• Temporary skin discoloration
• Increased sensitivity to sunlight
• Allergic reactions (rare) such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat.

Following are the precautions and warnings for Dithranol 0.35%w/w, Ichthammol 0.85%w/w, Resorcinol 0.002, Salicylic Acid 0.3%w/w Ointment:

• Avoid contact with eyes, mouth, and open wounds. In case of accidental contact, rinse thoroughly with water.
• This ointment is for external use only and should not be ingested.
• Wash your hands thoroughly after applying the ointment to avoid accidental transfer to sensitive areas.
• Do not use on broken or infected skin, and discontinue use if irritation or sensitivity occurs.
• Keep out of reach of children. If accidentally ingested, seek medical attention immediately.
• Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as they may advise caution or alternative treatments.
• This ointment may cause skin discoloration or staining; avoid contact with clothing and fabrics.

Following are the drug interaction considerations for Dithranol 0.35%w/w, Ichthammol 0.85%w/w, Resorcinol 0.002, and Salicylic Acid 0.3%w/w Ointment:

• This combination may increase skin sensitivity, especially when used with other topical agents like benzoyl peroxide or retinoids, potentially causing skin irritation or increased photosensitivity.
• Concomitant use with systemic retinoids or other medications that cause photosensitivity (e.g., certain antibiotics, diuretics) may increase the risk of sunburn and skin reactions.
• Salicylic acid may interact with anticoagulants, increasing the risk of bleeding. Monitoring is advised when used with medications like warfarin.
• Dithranol can enhance the effects of other keratolytic agents, potentially leading to excessive skin peeling and irritation.
• Topical use with corticosteroids may mask the signs of skin irritation or infection, requiring careful monitoring.
• The ointment's keratolytic effect may be enhanced by other medications that increase skin sensitivity, such as certain chemotherapy drugs.
• When combined with other medications containing salicylates, there is a potential risk of salicylate toxicity, especially in children.

Following are the food interactions for Dithranol 0.35%w/w, Ichthammol 0.85%w/w, Resorcinol 0.002, Salicylic Acid 0.3%w/w Ointment:

• Avoid alcohol-based beverages or products, as alcohol can increase skin dryness and irritation, especially when used with Salicylic Acid.
• Caffeine intake should be monitored, as it may interact with Resorcinol and affect its effectiveness.
• Avoid spicy foods, as they can cause skin flushing and exacerbate skin conditions, potentially interacting with Ichthammol.
• Grapefruit and its derivatives can impact the metabolism of certain compounds; consult your pharmacist for potential interactions with the ingredients in this ointment.
• Dairy products may influence the absorption of Salicylic Acid; consult your healthcare provider for personalized advice.
• Avoid high-fat meals, as they may delay the absorption of certain active components in the ointment.
• Stay hydrated by drinking adequate water to support the skin's natural processes when using this ointment.

Dithranol 0.35%w/w, Ichthammol 0.85%w/w, Resorcinol 0.002, Salicylic Acid 0.3%w/w Ointment should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. Avoid extreme temperatures by not storing it in hot environments like near a stove or inside a car during hot weather. Dispose of any unused or expired ointment responsibly; do not pour it down the drain or flush it. Consult a pharmacist for guidance on proper disposal methods. Keep the ointment out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Dithranol, Ichthammol, Resorcinol, and Salicylic Acid Ointment:

• Apply a thin layer of the ointment to the affected area as directed by your doctor or pharmacist.
• Wash your hands before and after applying the ointment to maintain hygiene.
• Gently cleanse the affected skin before application to ensure better absorption.
• Avoid applying the ointment on broken or irritated skin to prevent further irritation.
• Do not cover the treated area with bandages or tight clothing to allow it to breathe.
• Store the ointment at room temperature, away from direct sunlight and moisture.
• Inform your doctor if you experience excessive skin irritation or if symptoms persist.