Angilingual (0.5mg) 30 Tablets

Glyceryl Trinitrate, also known as nitroglycerin, primarily exerts its therapeutic effects through its conversion to nitric oxide (NO) in the body. This process occurs after the drug is metabolized, mainly in the blood vessels. Nitric oxide is a potent vasodilator, meaning it relaxes and widens blood vessels. Specifically, it acts on the smooth muscle cells in the vascular endothelium by activating soluble guanylate cyclase, which leads to an increase in cyclic guanosine monophosphate (cGMP). This rise in cGMP causes a decrease in intracellular calcium levels, resulting in smooth muscle relaxation. Consequently, blood vessels dilate, leading to reduced vascular resistance and decreased blood pressure. This mechanism is particularly beneficial in conditions where vasodilation is desired, such as in the treatment of angina pectoris, as it enhances blood flow to the heart and reduces the heart's workload.

Glyceryl Trinitrate 0.5mg

Nitrate vasodilator

Tablet

The following are the uses of Glyceryl Trinitrate 0.5mg Tablet:

• Used for treating and preventing chest pain caused by reduced blood flow to the heart, known as angina.
• Used to manage and control acute angina episodes, providing rapid relief.
• Used in emergency situations, such as during a heart attack, to improve blood flow to the heart.
• Used for the treatment of hypertension (high blood pressure) in specific cases.
• Used to prevent and manage chronic stable angina, enabling patients to engage in physical activities with reduced pain.
• Used to treat coronary artery disease by dilating blood vessels and improving blood circulation.
• Used to prevent and manage angina attacks triggered by physical exertion or emotional stress.

In the case of an overdose of Glyceryl Trinitrate 0.5mg Tablets, it is important to recognize the potential symptoms. These may include severe headaches, dizziness, fainting, and a rapid or pounding heartbeat. If an overdose is suspected, seek medical advice promptly. The recommended course of action may involve close monitoring of vital signs and, in severe cases, hospitalization. Quick response and medical intervention are key to managing and minimizing the risks associated with this type of overdose.

In the case of a missed dose of Glyceryl Trinitrate 0.5mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for advice on how to safely resume your medication regimen.

To take the Glyceryl Trinitrate 0.5mg Tablet, place it under your tongue when you experience angina symptoms or as directed by your doctor, allowing it to dissolve completely.

Following are the conditions/situations when Glyceryl Trinitrate 0.5mg Tablet should not be used:

• Must not be taken by individuals with known hypersensitivity or allergy to Glyceryl Trinitrate or similar nitrates.
• Contraindicated in patients with severe anemia, as it can worsen oxygen supply to vital organs.
• Should not be used in individuals with recent head injury or increased intracranial pressure.
• Avoid using in patients with severe hypotension (very low blood pressure) as it can further lower blood pressure.
• Not recommended for individuals with cardiac tamponade (fluid around the heart).
• Contraindicated in patients with pericardial constriction (stiffening of the heart's membrane).
• Should not be used during aortic stenosis (narrowing of the aortic valve in the heart).
• Avoid in patients with hypertrophic obstructive cardiomyopathy (a specific type of heart muscle disease).
• Must not be used in patients with acute myocardial infarction (heart attack) with low filling pressure.
• Not suitable for individuals with coronary artery disease with low-filling pressure.

The side effects of Glyceryl Trinitrate 0.5mg Tablet may include:

• Severe headaches or migraines
• Dizziness or lightheadedness
• Flushing or redness of the skin
• Palpitations or increased heart rate
• Nausea and vomiting
• Sweating
• Weakness or fatigue
• Skin rashes or itching

Following are the precautions and warnings for Glyceryl Trinitrate 0.5mg Tablet:

• Do not use if you are allergic to Glyceryl Trinitrate or any other nitrates.
• This medication is intended for sublingual or buccal use only; do not swallow the tablet.
• Exercise caution if you have low blood pressure as this medication may cause a further drop in blood pressure.
• Patients with a history of heart problems, especially those with recent heart attacks, should use it under close medical supervision.
• Avoid alcohol consumption while taking this medication as it may increase the risk of side effects.
• If you experience severe or persistent headaches, dizziness, or fainting, seek medical attention immediately.
• Store Glyceryl Trinitrate tablets in a cool, dry place, and keep them out of reach of children and pets.

Following are the drug interactions for Glyceryl Trinitrate 0.5mg Tablet:

• Alcohol consumption can increase the hypotensive effects of this medication, leading to excessive dizziness and lightheadedness.
• Nitrates like Glyceryl Trinitrate may interact with phosphodiesterase-5 (PDE-5) inhibitors such as sildenafil, tadalafil, and vardenafil, causing a significant drop in blood pressure.
• Calcium channel blockers, such as amlodipine, can enhance the vasodilatory effects, potentially leading to severe hypotension.
• Beta-blockers, including propranolol, may reduce the effectiveness of Glyceryl Trinitrate by inhibiting its metabolic activation.
• Medications that affect platelet function, like clopidogrel, may increase the risk of bleeding when used concurrently.
• Glyceryl Trinitrate may interact with other vasodilators, resulting in excessive blood pressure reduction.
• Certain medications metabolized by the liver, like phenytoin, may have altered blood levels when used with this drug.

Following are the food interactions for Glyceryl Trinitrate 0.5mg Tablet:

• Grapefruit juice can increase the blood levels of Glyceryl Trinitrate, leading to a potential increase in side effects. It is best to avoid consuming grapefruit or its juice while taking this medication.
• Alcohol consumption should be limited or avoided as it may cause excessive vasodilation, resulting in low blood pressure and increased side effects like dizziness and lightheadedness.
• High-fat meals might slightly delay the absorption of Glyceryl Trinitrate, but it generally has minimal impact on its effectiveness.
• Caffeine-rich beverages like coffee and tea may interact, potentially reducing the effectiveness of the medication. It is advisable to limit caffeine intake.
• Avoid large meals immediately after taking the tablet, as it can affect the absorption rate.
• Do not consume energy drinks or highly caffeinated beverages, as they may interact and cause irregular heart rhythms.
• Certain foods rich in nitrates, such as processed meats, might interact and increase the risk of side effects.

Glyceryl Trinitrate 0.5mg Tablets should be stored in a cool, dry place, preferably at room temperature between 59°F and 86°F (15°C and 30°C). Keep the tablets in their original container, tightly sealed, to protect them from light and moisture. It is crucial not to store them in the bathroom or any other humid environment. Avoid exposure to heat, as it can degrade the medication. Always check the expiration date, and do not use the tablets if they have passed their expiry. For disposal, do not flush the tablets down the toilet or throw them into the trash. Contact your pharmacist or a local waste disposal company for guidance on safe disposal methods. Keep this medication securely locked away from children and pets to prevent accidental consumption.

Following are the quick tips for Glyceryl Trinitrate 0.5mg Tablet:

• Place the tablet under your tongue for rapid absorption.
• Allow the tablet to dissolve completely, do not chew or swallow it.
• Avoid drinking hot beverages immediately after taking the tablet.
• Ensure you are in a sitting or lying position when taking the medication.
• Do not take the tablet if you are already experiencing a severe headache.
• Store the tablets in their original container, protected from light and moisture.
• Consult your doctor if chest pain worsens or persists after taking the tablet.