Angiocard SR (2.5mg) 30 Capsules

Glyceryl Trinitrate, also known as nitroglycerin, has a primary mechanism of action that involves the release of nitric oxide (NO) in the body. When administered, it rapidly enters the bloodstream and undergoes enzymatic conversion to nitric oxide, primarily in the vascular smooth muscle cells. Nitric oxide then activates soluble guanylate cyclase, leading to an increase in cyclic guanosine monophosphate (cGMP) levels. This increase in cGMP causes smooth muscle relaxation, particularly in the walls of blood vessels. The relaxation of vascular smooth muscle results in vasodilation, which lowers blood pressure by reducing peripheral resistance and decreasing the workload on the heart. This mechanism is particularly beneficial in conditions where rapid vasodilation is required, such as in the management of angina pectoris and acute heart failure.

Glyceryl Trinitrate 0.5mg

vasodilator

Capsule

The following are the uses of Glyceryl Trinitrate 0.5mg Capsule:

• Used for managing and preventing chest pain in conditions like Angina.
• Used to treat and provide relief from severe heart failure.
• Used to lower blood pressure in emergency situations.
• Used for the treatment of Angina attacks.
• Used to prevent and manage chest pain during physical activities or stress.
• Used to relax and dilate blood vessels, improving blood flow.
• Used for the immediate relief of acute symptoms in Angina.
• Used as a short-term treatment to control and alleviate chest discomfort.

In the case of an overdose of Glyceryl Trinitrate 0.5mg Capsules, individuals may experience severe headaches, dizziness, and a sudden drop in blood pressure. Symptoms can include rapid or irregular heartbeat, flushing, and even fainting. Promptly seek medical assistance if you suspect an overdose, as it may lead to more serious complications. Emergency treatment involves monitoring vital signs, maintaining hydration, and administering medications to counteract the effects of the overdose.

In the case of a missed dose of Glyceryl Trinitrate 0.5mg Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. It is crucial to maintain consistency with this medication for optimal effectiveness.

To use Glyceryl Trinitrate 0.5mg Capsule, place the capsule under your tongue (sublingually) and allow it to dissolve completely, following the dosage instructions provided by your healthcare professional, usually starting with one capsule as directed for the treatment of angina attacks.

Here are the conditions or situations when Glyceryl Trinitrate 0.5mg Capsule should not be taken:

• Should not be used in individuals with a known allergy to Glyceryl Trinitrate or nitrates.
• Contraindicated in patients with severe anemia, as it can worsen oxygen supply.
• Avoid using in individuals with recent head injury or increased intracranial pressure.
• Not recommended for patients with certain heart conditions like severe aortic stenosis, hypertrophic obstructive cardiomyopathy, or constrictive pericarditis.
• Should not be used in individuals with severe hypotension (very low blood pressure).
• Contraindicated during the acute phase of a heart attack (myocardial infarction).
• Not suitable for patients with acute glaucoma.

The side effects of Glyceryl Trinitrate 0.5mg Capsule may include:

• Severe headaches
• Dizziness or lightheadedness
• Skin rashes or itching
• Rapid or irregular heartbeat
• Flushing (feeling warm or reddening of the skin)
• Nausea and vomiting
• Weakness and fatigue
• Drop in blood pressure

Following are the precautions and warnings for Glyceryl Trinitrate 0.5mg Capsule:

• Do not use if you have an allergy to Glyceryl Trinitrate or other nitrates. Severe reactions may occur.
• Exercise caution in patients with low blood pressure as this medication can cause a further drop in blood pressure, leading to dizziness or fainting.
• Patients with a recent head injury, brain hemorrhage, or increased intracranial pressure should use with caution as it can increase intracranial pressure.
• Avoid consuming alcohol while taking this medication as it may enhance the blood pressure-lowering effect and increase the risk of dizziness or fainting.
• This medication may cause reflex tachycardia (increased heart rate) and should be used with caution in patients with angina pectoris.
• Patients with severe anemia should use it with caution as it can reduce oxygen delivery to tissues.
• Glyceryl Trinitrate capsules should be stored in a tightly closed container, protected from light, and kept at room temperature.

Following are the drug interactions for Glyceryl Trinitrate 0.5mg Capsule:

• Alcohol consumption can enhance the blood pressure-lowering effect of glyceryl trinitrate, leading to potential hypotension.
• When combined with phosphodiesterase type 5 inhibitors (e.g., sildenafil, tadalafil), the vasodilatory effects may be additive, resulting in significant blood pressure drop.
• Medications like beta-blockers, calcium channel blockers, and ACE inhibitors, when used with glyceryl trinitrate, can cause excessive blood pressure reduction.
• The use of glyceryl trinitrate with other nitrates or nitric oxide donors may result in additive vasodilatory effects and hypotension.
• Glyceryl trinitrate may interact with certain antihypertensive drugs, increasing the risk of orthostatic hypotension.
• It can interact with diuretics, potentially causing electrolyte imbalances and exacerbating hypotensive effects.
• Caution is advised when using glyceryl trinitrate with drugs that affect platelet function, as this may increase bleeding risk.

Following are the food interactions for Glyceryl Trinitrate 0.5mg Capsule:

• Avoid drinking alcohol while taking this medication as it can cause severe headaches and low blood pressure.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the effect of Glyceryl Trinitrate, leading to an excessive drop in blood pressure.
• High-fat meals may delay the absorption of the drug, potentially reducing its effectiveness.
• Caffeine intake should be monitored as it can constrict blood vessels, counteracting the medication's effect.
• Avoid large meals or heavy food as they can increase the workload on the heart, especially after taking the medication.
• Stay hydrated by drinking enough water to maintain blood volume and prevent low blood pressure.
• Certain foods rich in nitrates, like beetroot and spinach, might interact with the medication, affecting blood vessel dilation.

Glyceryl Trinitrate 0.5mg Capsules should be stored in a cool and dry place, preferably in a medicine cabinet or a designated storage area. Keep the capsules in their original packaging, tightly sealed, to protect them from moisture and light. It is crucial to maintain a consistent room temperature, avoiding exposure to direct sunlight, heat, or freezing conditions, as these can degrade the medication. Do not store the capsules in the bathroom or kitchen, as these areas often experience temperature fluctuations. Always check the expiration date, and dispose of any unused or expired capsules responsibly. Do not flush them down the toilet or throw them into the trash; instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for guidance on safe disposal methods. Keep the medication out of the reach of children and pets to prevent accidental ingestion.

Following are the quick tips for Glyceryl Trinitrate 0.5mg Capsule:

• Store the capsules in a cool, dry place, away from direct sunlight.
• Ensure you are aware of potential side effects and inform your doctor if any occur.
• Take the capsule as soon as you experience chest pain, as directed by your doctor.
• Do not exceed the prescribed dosage without medical advice.
• Avoid alcohol consumption while using this medication.
• Consult your doctor if you have any underlying medical conditions before taking this medicine.
• Inform your healthcare provider about all medications you are currently taking.