Anifed Retard (20mg) 50 Tablets

Nifedipine, a 20mg tablet, acts as a calcium channel blocker, primarily targeting L-type calcium channels in vascular smooth muscle cells. Its mechanism of action involves blocking the entry of extracellular calcium into these cells, leading to smooth muscle relaxation. By inhibiting calcium influx, nifedipine promotes vasodilation, particularly in the peripheral and coronary arteries. This dilation reduces vascular resistance, resulting in decreased blood pressure and improved blood flow to the heart. The selective action on vascular smooth muscle makes nifedipine effective in treating hypertension and angina, as it directly impacts the regulation of vascular tone and reduces the workload on the heart.

Calcium channel blocker

Tablet

The following are the uses of Nifedipine 20mg Tablet:

• Used for managing high blood pressure, effectively lowering and controlling hypertension.
• Used for treating angina, providing relief from chest pain and discomfort.
• Used for preventing angina attacks, allowing for better management of the condition.
• Used for relaxing and widening blood vessels, improving blood flow and circulation.
• Used for treating Raynaud's phenomenon, reducing the severity and frequency of attacks.
• Used for managing preterm labor, helping to relax the uterus and delay premature contractions.
• Used for maintaining cardiovascular health, supporting overall heart and blood vessel function.
• Used for managing certain types of headaches, particularly those related to blood vessel constriction.

Take as per doctor's prescription

In the case of an overdose of Nifedipine 20mg Tablets, it is important to recognize the potential severity of this situation. Overdosing on Nifedipine can lead to symptoms such as low blood pressure, dizziness, and even fainting. If you suspect an overdose, seek medical advice promptly. Prompt action may include contacting a healthcare professional or emergency services, who can provide guidance on the necessary steps to address the overdose and ensure the individual's well-being. Timely intervention is crucial in managing the potential risks associated with Nifedipine overdose.

In the case of a missed dose of Nifedipine 20mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or adjust the dosage accordingly. It is advisable to maintain a consistent dosing routine to ensure the effectiveness of the treatment.

To take Nifedipine 20mg Tablet, swallow the tablet whole with a glass of water, following the prescribed dosage as directed by your healthcare provider, typically once daily, and ensure you do not crush, chew, or break the tablet to maintain its effectiveness.

Nifedipine 20mg Tablet should not be used in the following conditions:

• Avoid using this medication if you have a known allergy to Nifedipine or other calcium channel blockers.
• Do not take this tablet if you have unstable angina (chest pain) or within the first month of a heart attack.
• Contraindicated in individuals with severe hypotension (very low blood pressure).
• Not suitable for patients with aortic stenosis (narrowing of the aortic valve in the heart).
• Should not be used if you have a heart condition called 'cardiogenic shock'.
• Avoid if you have severe coronary artery disease.
• Do not use Nifedipine 20mg Tablet if you have a condition called 'Sick sinus syndrome'.

The side effects of Nifedipine 20mg Tablet may include:

• Dizziness
• Headache
• Nausea and vomiting
• Fatigue and weakness
• Flushing (warmth and redness in the face)
• Peripheral edema (swelling in the legs and ankles)
• Rapid heart rate (tachycardia)
• Gastrointestinal discomfort

Following are the precautions and warnings for Nifedipine 20mg Tablet:

• Not recommended for individuals with known allergies to Nifedipine or other calcium channel blockers.
• Patients with liver or kidney disease should use with caution and under medical supervision, as dosage adjustments may be necessary.
• May cause dizziness or lightheadedness, so caution is advised when performing tasks requiring alertness.
• Elderly patients may be more sensitive to the effects and should start with a lower dose.
• Not recommended for children unless prescribed by a pediatrician.
• Should be used with caution during pregnancy and breastfeeding, only if the potential benefits outweigh the risks.
• Patients with heart conditions, such as aortic stenosis or unstable angina, should use this medication with caution and under medical supervision.

Following are the drug interactions for Nifedipine 20mg Tablet:

• Concomitant use with CYP3A4 inducers (e.g., rifampin, St. John's Wort) may decrease Nifedipine levels, reducing its effectiveness.
• Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) can increase Nifedipine concentrations, leading to enhanced effects and potential side effects.
• Grapefruit juice should be avoided as it can inhibit CYP3A4 and increase Nifedipine levels.
• Beta-blockers may have an additive effect on lowering blood pressure when used with Nifedipine, requiring close monitoring.
• The use of Nifedipine with other calcium channel blockers may lead to increased hypotension and cardiac depression.
• Combining Nifedipine with digoxin can increase digoxin levels, requiring careful monitoring of digoxin concentrations.
• Anticonvulsants like phenytoin or carbamazepine may decrease Nifedipine levels, potentially reducing its therapeutic effect.

Following are the food interactions for Nifedipine 20mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they can increase the blood levels of Nifedipine, potentially leading to an increased risk of side effects.
• Alcohol consumption should be minimized as it may cause excessive lowering of blood pressure and increase the sedative effects of Nifedipine.
• High-fat meals may slightly decrease the absorption of Nifedipine, so it is best to take the medication on an empty stomach or with a low-fat meal.
• Avoid excessive consumption of licorice as it may decrease the effectiveness of Nifedipine by reducing potassium levels in the body.
• Avoid or limit the intake of Seville oranges (often used in marmalades) as they contain compounds that can affect the metabolism of Nifedipine.
• Be cautious with natural licorice-containing products as they may interact with Nifedipine, affecting blood pressure and heart rate.
• Avoid large amounts of St. John's Wort as it may decrease Nifedipine levels in the body, reducing its effectiveness.
• Consult your healthcare provider about any specific dietary restrictions or recommendations while taking Nifedipine to ensure optimal treatment outcomes.

Nifedipine 20mg Tablets should be stored in a secure and dry location, preferably at room temperature, ensuring protection from light and moisture. The original container should be used to safeguard the tablets from potential contamination. It is crucial to avoid placing the medication in bathrooms or areas exposed to heat, such as near stoves or radiators, as temperature fluctuations can compromise its effectiveness. Prior to using the tablets, always verify the expiration date on the packaging. When disposing of unused or expired tablets, refrain from flushing them down the toilet or pouring them into drains. Instead, consult a pharmacist or healthcare professional for guidance on appropriate disposal methods. Additionally, keep the medication out of children's reach to prevent accidental ingestion.

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Following are the quick tips for Nifedipine 20mg Tablet:

• Consult your doctor for the right dosage and duration of this medication.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• Take it at the same time each day to maintain consistent blood levels.
• If you experience dizziness, rise slowly from a sitting or lying position.
• Avoid grapefruit and its juice during treatment.
• Inform your doctor about all medications you are taking.
• Store in a cool, dry place, away from direct sunlight.
• Do not share this medication with others; it is prescribed specifically for your condition.