Aparox (300mg) 10 Tablets

Aparox (300mg) 10 Tablets

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  • Manufacturer SIZA INT LTD
  • Generic Name Roxithromycin

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Roxithromycin 300mg Tablet exerts its antibacterial effect through multiple mechanisms. Primarily, it binds to the 50S subunit of bacterial ribosomes, thereby inhibiting protein synthesis. This binding interferes with the translocation step, preventing the ribosome from moving along the messenger RNA, which is crucial for the production of essential proteins in bacteria. Roxithromycin is particularly effective against gram-positive bacteria and some gram-negative bacteria, as it can penetrate their cell walls and reach the ribosomes. The drug's ability to disrupt bacterial protein synthesis leads to bacterial growth inhibition and, ultimately, cell death. This mechanism of action contributes to its effectiveness in treating various bacterial infections.

  • Ingredients

    Roxithromycin
  • Drug Class

    Macrolide antibiotic

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Roxithromycin 300mg Tablet:

    • Used for treating bacterial infections such as respiratory tract infections, skin infections, and soft tissue infections.
    • Used for managing acute flare-ups of chronic bronchitis.
    • Used for treating travelers' diarrhea caused by certain bacteria.
    • Used for preventing and treating Mycobacterium avium complex (MAC) infections in HIV-positive patients.
    • Used for controlling and reducing the symptoms of acne vulgaris.
    • Used for managing ear, nose, and throat infections.
    • Used for addressing gastrointestinal infections caused by susceptible bacteria.
    • Used for the treatment of Legionnaires' disease.
  • In case of Overdose

    In the case of an overdose of Roxithromycin 300mg Tablets, individuals may experience an increase in the severity of common side effects such as gastrointestinal disturbances, including nausea, vomiting, and diarrhea. Other potential symptoms of overdose may include headache, dizziness, and skin rashes. It is important to seek medical advice if an overdose is suspected, as prompt intervention can help manage symptoms and prevent potential complications. The healthcare provider may recommend supportive measures and monitor the individual's vital signs to ensure a safe recovery.

  • Missed Dose

    In the case of a missed dose of Roxithromycin 300mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you have missed multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen without compromising its effectiveness. It is recommended to set a daily reminder to help you stay on track with your medication.

  • How To Use

    To take Roxithromycin 300mg Tablet, swallow the tablet whole with a full glass of water, preferably with food, once or twice a day as directed by your healthcare professional, ensuring you complete the full prescribed course.

  • When Not to Use

    Here are the conditions and situations when Roxithromycin 300mg Tablet should not be used:

    • Must not be taken by individuals who are allergic to Roxithromycin or similar antibiotics like Erythromycin, Clarithromycin, or any other macrolide antibiotics.
    • Not suitable for patients with severe liver impairment or active liver disease.
    • Contraindicated in patients with a history of jaundice or liver problems caused by previous use of Roxithromycin or similar antibiotics.
    • Should not be used in individuals with a known or suspected prolongation of the QT interval (a heart-related condition).
    • Avoid using in patients with severe kidney disease or those on dialysis.
    • Not recommended for children weighing less than 40 kg.
    • Do not administer to patients with a history of myasthenia gravis.
  • Side Effects

    The side effects of Roxithromycin 300mg Tablet may include:

    • Nausea and vomiting
    • Diarrhea
    • Abdominal pain or discomfort
    • Skin rash or itching
    • Headache
    • Dizziness
    • Altered taste sensation
    • Hearing disturbances
  • Precautions & Warnings

    Following are the precautions and warnings for Roxithromycin 300mg Tablet:

    • Allergic reactions may occur; discontinue use and seek medical attention if you experience symptoms like rash, itching, or difficulty breathing.
    • This medication may cause liver problems; monitor liver function and inform your doctor if you have existing liver issues.
    • Roxithromycin can interact with other drugs, including anticoagulants and antacids, so inform your doctor about all medications you are taking.
    • It may cause diarrhea, and in some cases, it can be severe. Contact your doctor if you experience persistent or severe diarrhea.
    • Avoid prolonged exposure to sunlight and wear protective clothing, as this medication may increase photosensitivity.
    • Patients with myasthenia gravis should exercise caution, as Roxithromycin may worsen muscle weakness.
    • Inform your doctor if you have a history of cardiac issues, as this medication has been associated with cardiac side effects.
    • Do not exceed the prescribed dosage, as it may increase the risk of adverse effects.
  • Drug Interactions

    Following are the drug interactions for Roxithromycin 300mg Tablet:

    • Avoid with drugs metabolized by CYP3A4 (e.g., midazolam, cisapride, ergotamine, simvastatin), as it may increase their levels and risk of adverse effects.
    • Concomitant use with digoxin may increase digoxin levels, requiring close monitoring.
    • Theophylline levels may rise, leading to potential toxicity.
    • Antacids containing aluminum or magnesium can reduce Roxithromycin absorption, so separate administration by at least 2 hours.
    • May increase concentration of terfenadine, astemizole, and cisapride, potentially causing cardiac arrhythmias.
    • H2-receptor antagonists and proton pump inhibitors may decrease Roxithromycin absorption.
    • Caution with drugs that prolong QT interval, as Roxithromycin may also affect cardiac repolarization.
  • Food Interactions

    Following are the food interactions for Roxithromycin 300mg Tablet:

    • Avoid consuming grapefruit and grapefruit juice as they can increase the drug concentration in the body, potentially leading to an increased risk of side effects.
    • Alcohol consumption should be minimized or avoided as it may cause liver damage and increase the risk of adverse effects.
    • Dairy products like milk, cheese, and yogurt may decrease the absorption of Roxithromycin, so take the medicine at least 2 hours before or after consuming dairy.
    • Avoid high-fat meals as they can delay the absorption of Roxithromycin, affecting its effectiveness.
    • Avoid caffeine-rich beverages like coffee and energy drinks as they may increase the metabolism of Roxithromycin, reducing its efficacy.
    • Herbal supplements like St. John's Wort should be used cautiously as they may decrease Roxithromycin levels in the body.
    • Always inform your healthcare provider about your dietary habits to ensure the medication's effectiveness and safety.
    • Maintain a balanced diet to support your overall health during the medication course.
  • Storage/Disposal

    Roxithromycin 300mg Tablets should be stored in a cool and dry place, preferably at room temperature (around 25°C/77°F). Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity and protect it from moisture. Avoid exposure to direct sunlight, heat, or freezing temperatures, as this can degrade the medication. It is crucial to discard any unused or expired tablets according to local guidelines and regulations. Do not flush or pour them into water bodies; instead, consult your pharmacist or local waste management authority for appropriate disposal options. Keep the medication out of children's reach to prevent accidental consumption.

  • Quick Tips, if any

    Following are the quick tips for Roxithromycin 300mg Tablet:

    • Take the tablet as directed by your doctor, typically with or after food.
    • Ensure you complete the full prescribed course, even if symptoms improve.
    • Maintain a consistent time for taking the tablet each day.
    • Avoid crushing or chewing the tablet; swallow it whole with water.
    • Inform your doctor if you have liver or kidney disease before taking this medication.
    • Store the tablets in a cool, dry place, away from direct sunlight.
    • Do not share this medication with others, even if their symptoms are similar.

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