Apresoline (25mg) 84 Tablets

Hydralazine HCl tablets act as a direct-acting vasodilator, primarily targeting smooth muscle cells in blood vessels. The mechanism of action involves the drug's ability to inhibit the binding of calcium ions to calmodulin, which is crucial for the contraction of smooth muscle cells. By interfering with calcium-calmodulin interactions, hydralazine relaxes the vascular smooth muscle, leading to peripheral vasodilation. This relaxation of blood vessels results in reduced vascular resistance, decreased arterial blood pressure, and improved blood flow, particularly in conditions like hypertension where there is elevated blood pressure. The selective action on vascular smooth muscle makes hydralazine effective in lowering blood pressure without directly affecting the heart's contractility.

HYDRALAZINE HCl

Antihypertensive

Tablet

The following are the uses of HYDRALAZINE HCl Tablet:

• Used for treating severe hypertension
• Used to lower blood pressure in emergencies
• Used for managing high blood pressure during pregnancy
• Used to improve blood flow in Raynaud's disease
• Used for heart failure treatment
• Used to reduce complications in aortic dissection
• Used to prevent and treat chronic heart failure symptoms
• Used to manage blood pressure in preeclampsia and eclampsia

In the case of an overdose of HYDRALAZINE HCl Tablets, individuals may experience symptoms such as severe hypotension, bradycardia, and dizziness. The severity of these effects can vary depending on the amount ingested. It is crucial to seek medical assistance promptly, where healthcare professionals can provide appropriate treatment and support to manage the overdose, including monitoring vital signs and administering necessary interventions. Timely action is essential to prevent potential complications.

In the case of a missed dose of HYDRALAZINE HCl Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen.

To take HYDRALAZINE HCl Tablets, swallow the tablet whole with a glass of water, following the prescribed dosage instructions provided by your healthcare professional, typically taken two to four times a day or as directed by your doctor.

Following are the conditions when HYDRALAZINE HCl Tablet should not be used:

• Should not be taken by individuals with a known allergy to hydralazine or any other ingredients in the medication.
• Contraindicated in patients with coronary artery disease who have suffered a recent heart attack.
• Not recommended for individuals with severe kidney disease or renal impairment.
• Should not be used if you have a history of lupus or systemic lupus erythematosus (SLE).
• Contraindicated in patients with aortic or mitral valve stenosis.
• Not suitable for individuals with pheochromocytoma, a rare tumor of the adrenal gland.
• Should be avoided during the first trimester of pregnancy and breastfeeding.
• Do not use in patients with cerebral or coronary insufficiency.

The side effects of HYDRALAZINE HCl Tablet may include:

• Headache
• Dizziness
• Nausea and vomiting
• Loss of appetite
• Diarrhea
• Skin rashes or itching
• Chest pain or discomfort
• Rapid or irregular heartbeat

Following are the precautions and warnings for HYDRALAZINE HCl Tablet:

• This medication should be used with caution in patients with kidney disease, as it may require dosage adjustments to prevent potential kidney damage.
• Patients with a history of heart disease, particularly those with coronary artery disease, should be closely monitored during treatment.
• HYDRALAZINE HCl can cause a sudden and significant drop in blood pressure, leading to dizziness and fainting. Patients should exercise caution when standing up, especially from a lying or sitting position.
• It may cause a condition called Lupus-like syndrome, which can lead to joint pain, rash, and fever. Discontinue use and seek medical attention if these symptoms occur.
• Elderly patients may be more sensitive to the effects of this medication, particularly the drop in blood pressure.
• Not recommended for use during pregnancy unless clearly needed. It may have potential risks to the fetus.
• Breastfeeding women should consult their healthcare provider as it may pass into breast milk and affect nursing infants.

Following are the drug interactions for HYDRALAZINE HCl Tablet:

• When combined with other antihypertensive medications, such as beta-blockers or diuretics, it may cause excessive blood pressure reduction.
• The effectiveness of HYDRALAZINE can be reduced by drugs like rifampin, which induce certain liver enzymes.
• It can interact with tricyclic antidepressants, potentially increasing their levels and leading to more pronounced side effects.
• Using it with other vasodilators might result in excessive blood pressure reduction and increased risk of hypotension.
• Sympathomimetic agents, including epinephrine, may counteract the effects of HYDRALAZINE, leading to reduced blood pressure control.
• Nitrates, when used with HYDRALAZINE, can cause additive vasodilation, possibly resulting in severe hypotension.
• Alcohol consumption can enhance the blood pressure-lowering effect of HYDRALAZINE, potentially causing dizziness or lightheadedness.
• Drugs that affect the renin-angiotensin system, such as ACE inhibitors, may have an additive effect on blood pressure reduction.

Following are the food interactions for HYDRALAZINE HCl Tablet:

• Avoid consuming large amounts of tyramine-rich foods like aged cheeses, cured meats, fermented foods, and certain types of beans. Tyramine can increase blood pressure and interact with the medication.
• Limit your intake of sodium-rich foods as sodium can counteract the blood pressure-lowering effects of HYDRALAZINE.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed in moderation as HYDRALAZINE can increase potassium levels in the body.
• Grapefruit and grapefruit juice should be avoided as they may affect the metabolism of the drug.
• Alcohol may increase the blood pressure-lowering effect of HYDRALAZINE, so it's best to limit or avoid alcohol consumption.
• Caffeine-rich beverages like coffee and energy drinks might interfere with blood pressure control and should be consumed in moderation.
• There is no specific diet restriction, but maintaining a balanced and healthy diet is recommended for overall well-being.

Hydralazine HCl tablets should be stored in a cool, dry location, ideally at room temperature, ensuring protection from direct sunlight and moisture. Maintain the medication in its original, tightly sealed container to prevent contamination. Avoid storage in bathrooms or near heat-emitting appliances like stoves or radiators, as temperature fluctuations can compromise the drug's integrity. Prior to administration, verify the packaging for the expiration date, and responsibly dispose of any unused or expired tablets. Refrain from flushing them down the toilet or pouring them down the drain; instead, consult a pharmacist or healthcare professional for appropriate disposal guidelines. It is crucial to keep the medication securely stored and out of the reach of children to prevent accidental ingestion.

Following are the quick tips for HYDRALAZINE HCl Tablet:

• Consult your doctor for the right dosage and duration of treatment.
• Swallow the tablet whole with a glass of water; do not crush or chew.
• Take the tablet as directed, usually 2 to 4 times a day, at evenly spaced intervals.
• Maintain a consistent schedule to ensure the medication's effectiveness.
• If you experience side effects like dizziness, lie down until it passes.
• Inform your doctor if you have any heart, kidney, or liver conditions.
• Store the medication at room temperature, away from moisture and heat.