Aprovel (300mg) 28 Tablets

Irbesartan is an angiotensin II receptor blocker (ARB) that selectively blocks the binding of angiotensin II to AT1 receptors, which are found in many tissues, including vascular smooth muscle and the adrenal glands. Angiotensin II is a potent vasoconstrictor, and by blocking its effects, irbesartan prevents the vasoconstriction and release of aldosterone that normally occur with angiotensin II binding. This mechanism of action leads to relaxation of the blood vessels, resulting in decreased blood pressure. Irbesartan 300mg specifically blocks the AT1 receptor, which is responsible for the vasopressor effects of angiotensin II, including the release of aldosterone, catecholamines, and vasopressin. This action reduces peripheral vascular resistance, leading to decreased blood pressure without affecting the heart rate.

Irbesartan 300mg

Angiotensin II receptor blocker

Tablet

The following are the uses of Irbesartan 300mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used to lower blood pressure and protect the kidneys
• Used for patients with heart issues, reducing the risk of heart attack or stroke
• Used to manage diabetic kidney disease
• Used to improve blood flow and reduce the workload on the heart
• Used to treat kidney disease caused by diabetes
• Used to prevent diabetic retinopathy
• Used to improve cardiovascular health in patients with hypertension

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Heart failure- Take 300mg once daily
• Hypertension- Take 150mg-300mg once daily
• Diabetic nephropathy- Take 300mg once daily

In the case of an overdose of Irbesartan 300mg Tablets, individuals may experience symptoms such as low blood pressure, increased heart rate, and dizziness. It is important to recognize that the severity of symptoms can vary depending on the amount ingested. If an overdose is suspected, it is advisable to seek medical advice promptly. Treatment may involve monitoring vital signs, providing supportive care, and ensuring the individual's hydration. Prompt action can help mitigate potential health risks associated with an overdose of this medication.

In the case of a missed dose of Irbesartan 300mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. If you miss multiple doses, contact your healthcare professional for advice, as they may recommend adjusting your dosage or provide specific instructions for catching up on missed doses safely.

To take Irbesartan 300mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, as directed by your healthcare provider, typically once daily, and it can be taken with or without food.

The following are the conditions when Irbesartan 300mg Tablet should not be taken:

• Must not be used in individuals with a known allergy to Irbesartan or any other angiotensin II receptor blockers (ARBs).
• Not suitable for individuals with a history of severe liver impairment or liver disease.
• Should not be used during pregnancy or breastfeeding.
• Contraindicated in patients with severe bile duct obstruction or bile duct narrowing.
• Not recommended for children under the age of 18 years.
• Avoid in patients with severe kidney disease or those on dialysis.

The side effects of Irbesartan 300mg Tablet may include:

• Dizziness
• Fatigue or tiredness
• Diarrhea
• Nausea
• Muscle cramps
• Joint pain
• Increased potassium levels in the blood
• Elevated liver enzymes

Following are the precautions and warnings for Irbesartan 300mg Tablet:

• Not recommended for individuals with a known allergy or hypersensitivity to Irbesartan or any other angiotensin II receptor blockers.
• Patients with a history of liver or kidney disease should exercise caution and consult a doctor, as Irbesartan may require dosage adjustments in such cases.
• Dehydrated patients or those with low blood volume should be monitored closely as Irbesartan can affect blood pressure regulation.
• Caution is advised for patients with a history of heart disease or congestive heart failure, as Irbesartan may affect their condition.
• Irbesartan may cause dizziness or lightheadedness, so patients should be cautious when standing up or performing tasks that require alertness.
• The use of Irbesartan during pregnancy and breastfeeding should be carefully considered and discussed with a healthcare professional.
• This medication may cause an increase in potassium levels, so regular monitoring is necessary, especially for patients with existing kidney problems.

Following are the drug interactions for Irbesartan 300mg Tablet:

• Irbesartan can increase the blood levels of lithium, leading to lithium toxicity. Close monitoring of lithium levels is necessary.
• The blood pressure-lowering effect of Irbesartan may be reduced when used with NSAIDs (e.g., ibuprofen, naproxen).
• When combined with diuretics, especially potassium-sparing diuretics, Irbesartan may cause elevated potassium levels in the blood.
• Taking Irbesartan with ACE inhibitors may further decrease blood pressure and increase the risk of kidney impairment.
• The antihypertensive effect of Irbesartan may be reduced by corticosteroids, which can increase blood pressure.
• The use of Irbesartan with other antihypertensive medications may result in additive blood pressure reduction.
• Irbesartan may increase the blood concentration of certain medications metabolized by the liver, including some antidepressants and antipsychotics.

Following are the food interactions for Irbesartan 300mg Tablet:

• Irbesartan can be taken without regard to meals, so it can be consumed with or without food.
• Avoid high-sodium foods as Irbesartan is a sodium-controlled medication.
• Limit alcohol consumption as it may increase the risk of lowering blood pressure, especially when first starting the medication.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed in moderation as Irbesartan can increase potassium levels.
• Grapefruit and grapefruit juice should be avoided as they may decrease the effectiveness of Irbesartan by altering its metabolism.
• No significant interactions with dairy products or calcium-rich foods have been reported.
• Always follow your doctor's advice regarding dietary restrictions and recommendations while taking Irbesartan.
• Stay hydrated by drinking enough fluids, especially if you experience dizziness or lightheadedness.

Irbesartan 300mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring it is protected from direct sunlight and moisture. Keep the tablets in their original packaging or container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial not to expose the medication to extreme temperatures, so avoid storing it in hot places like near a stove or inside a car. Always check the expiration date, and if the tablets are expired or no longer needed, do not flush them down the toilet or throw them into the garbage. Instead, consult your pharmacist or healthcare provider for guidance on safe disposal methods to protect the environment and prevent accidental consumption. Keep the medication away from children and pets at all times.

Following are the quick tips for Irbesartan 300mg Tablet:

• Consult your doctor before starting this medication to ensure it's suitable for you.
• Take the tablet orally as directed, typically once daily.
• Consistency is key; aim to take it at the same time each day.
• Swallow the tablet whole with a glass of water; do not crush or chew.
• Ensure you stand up slowly from a sitting or lying position to prevent dizziness.
• Regular blood pressure checks are essential while on this medication.
• Inform your doctor of all medications you are taking to avoid potential interactions.

Irbesartan is a medication that helps to manage high blood pressure, reducing the risk of stroke and heart attacks. It is important to note that blood pressure should be monitored while taking Irbesartan to ensure the medication is working effectively. Lab tests are crucial to monitor kidney function by keeping track of potassium levels, creatinine levels, and potassium-creatinine ratios. A blood cell count and lipid profile may also be requested by your doctor to check for any abnormalities. Depending on individual age and health history factors, lab tests may vary, so it is important to communicate with your healthcare provider to determine which specific tests are required to ensure your safety and well-being while taking Irbesartan.