Arceva (20/120mg) 16 Tablets

Artemether and Lumefantrine are both active components in the Artemether 20mg, Lumefantrine 120mg Tablet, and they work synergistically to combat malaria. Artemether, a derivative of artemisinin, exerts its antimalarial effect by reacting with intracellular heme (iron-containing component of malaria parasite metabolism), leading to the formation of toxic compounds that damage the parasite's membranes and inhibit its growth. This action primarily affects the later stages of the parasite's life cycle, particularly the mature forms. Lumefantrine, on the other hand, acts by inhibiting the parasite's ability to metabolize and break down vital nutrients, thereby disrupting its energy production and growth. This combination therapy is highly effective as it targets different stages of the parasite's life cycle, preventing resistance and ensuring rapid clearance of the malaria parasites from the bloodstream.

Artemether 20mg, Lumefantrine 120mg

Antimalarial medication.

Tablet

The following are the uses of Artemether 20mg, Lumefantrine 120mg Tablet:

• Used for treating acute, uncomplicated Plasmodium falciparum malaria.
• Used to kill the malaria parasite, which infects red blood cells.
• Used in cases where the parasite is resistant to other antimalarial drugs.
• Used to prevent and treat a specific type of malaria caused by a parasite.
• Used to reduce fever and other malaria symptoms.
• Used for both adults and children, with dosage adjusted according to weight.
• Used under medical supervision, with regular monitoring for side effects.
• Used as a combination therapy, requiring completion of the full course as prescribed.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Artemether Recommended dosage for treatment of malaria is approximately 5mg per kg of body weight per day, divided into 2-3 doses per day, taken after food for 3 days
• Artemether Recommended dosage for prevention of malaria is approximately 2.5mg per kg of body weight per day, divided into 2 doses per day, taken after food
• Lumefantrine Recommended dosage for treatment of malaria is approximately 10mg per kg of body weight per day, divided into 2 doses per day, taken with food for 3 days
• Lumefantrine should not be taken alone or with other antimalarials unless prescribed by a physician experienced in the treatment of malaria
• Lumefantrine is not recommended for children weighing less than 5 kg or 7.5 lb

In the case of an overdose of Artemether 20mg and Lumefantrine 120mg tablets, individuals may experience intensified side effects such as nausea, vomiting, dizziness, and headaches. More severe symptoms could include difficulty breathing, seizures, or an irregular heartbeat. It is crucial to seek immediate medical assistance and inform healthcare professionals about the overdose, as they can provide appropriate treatment and monitoring to manage any adverse reactions and ensure the patient's safety.

In the case of a missed dose of Artemether 20mg and Lumefantrine 120mg Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. However, if you have missed multiple doses, contact your healthcare provider for guidance on how to proceed, as they may recommend adjusting your dosage or provide specific instructions to ensure the treatment remains effective.

To take Artemether 20mg and Lumefantrine 120mg tablets, swallow the tablets whole with a glass of water, preferably after a meal or with a snack, following the dosage instructions provided by your healthcare professional.

Here are the conditions or situations when Artemether 20mg, Lumefantrine 120mg Tablet should not be used:

• Should not be used in individuals with a known allergy to artemether, lumefantrine, or any other similar antimalarial medications.
• Contraindicated in patients with a history of prolonged QT interval or other heart rhythm disorders.
• Not recommended for individuals with severe liver or kidney disease.
• Should not be used in patients with a history of seizures or epilepsy.
• Contraindicated during breastfeeding, as the medication may pass into breast milk and harm the nursing infant.
• Not suitable for individuals with a known blood disorder or a history of low blood sugar (hypoglycemia).
• Should be avoided in patients with a known allergy to other anti-parasitic medications.
• Do not use if you have a history of severe skin reactions to similar medications.

The side effects of Artemether 20mg, Lumefantrine 120mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Dizziness
• Headache
• Loss of appetite
• Muscle or joint pain
• Itching or rash
• Abnormal liver function tests

Following are the precautions and warnings for Artemether 20mg, Lumefantrine 120mg Tablet:

• This medication should not be taken by individuals with a known allergy to artemether, lumefantrine, or related compounds.
• Patients with a history of cardiac issues, such as heart disease or arrhythmias, should use this medication with caution and under medical supervision.
• Artemether-lumefantrine may cause dizziness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Patients with liver or kidney disease should inform their doctor, as dose adjustments may be necessary.
• The use of this medication should be closely monitored in elderly patients, as they may be more susceptible to side effects.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as it may have potential risks for the fetus and infant.
• It is important to complete the full course of treatment to ensure the effectiveness of the medication and prevent the development of drug-resistant parasites.

Following are the drug interactions for Artemether 20mg, Lumefantrine 120mg Tablet:

• Co-administration with rifampicin can reduce the plasma concentration of artemether and lumefantrine, potentially reducing their effectiveness.
• Use with efavirenz, nevirapine, or other strong CYP3A4 inducers may decrease the levels of lumefantrine, reducing its therapeutic effect.
• Artemether may increase the effects of anticoagulants, such as warfarin, requiring close monitoring of prothrombin time.
• Concomitant use with halofantrine can cause prolonged QT interval and arrhythmias. Avoid this combination.
• Drugs that prolong the QT interval, such as quinidine, should be used cautiously due to the risk of arrhythmias.
• Lumefantrine can inhibit CYP3A4, potentially increasing the levels of other drugs metabolized by this enzyme, including midazolam and atorvastatin.
• The absorption of lumefantrine may be reduced by antacids containing aluminum or magnesium hydroxide, decreasing its effectiveness.

Following are the food interactions for Artemether 20mg, Lumefantrine 120mg Tablet:

• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of the medication, leading to increased drug levels in the body.
• A high-fat meal can enhance the absorption of Artemether, thus increasing its bioavailability. It is recommended to take the medication with food to improve absorption.
• Fatty foods can enhance the absorption of Lumefantrine, so taking the tablet with a meal can improve its effectiveness.
• Avoid excessive alcohol consumption as it may interfere with the liver's ability to metabolize the medication, potentially affecting its efficacy.
• Caffeinated beverages may slightly reduce the absorption of Artemether, so consider reducing caffeine intake during treatment.
• Avoid bitter or strong-tasting foods/drinks like grapefruit, pomegranate, or bitter vegetables, as they may interfere with the taste and reduce the effectiveness of the medication.
• There is no specific food restriction with this medication, but maintaining a balanced diet is essential for overall health during treatment.
• Consult your healthcare provider for personalized advice on dietary considerations while taking this medication.

Artemether 20mg, Lumefantrine 120mg Tablets should be stored in a cool and dry place, preferably at room temperature (below 25°C/77°F). Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain their stability and protect them from moisture. Avoid exposure to direct sunlight or heat sources, as high temperatures can degrade the medication. It is crucial to check the expiration date before use and dispose of any expired or unused tablets responsibly. Do not flush or pour them into water sources; instead, follow local guidelines for pharmaceutical waste disposal. Always keep medicines secure and out of children's reach to prevent accidental consumption.

Following are the quick tips for Artemether 20mg, Lumefantrine 120mg Tablet:

• Take the tablet as directed by your doctor, usually once a day for three consecutive days.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Complete the full course of medication, even if you start feeling better.
• Take the tablet with food or a milky drink to enhance absorption.
• Avoid grapefruit and grapefruit juice while on this medication.
• Inform your doctor if you have any other medical conditions or are taking other medications.
• Store the tablets in a cool, dry place, away from direct sunlight.

When taking Artemether 20mg and Lumefantrine 120mg, it is important to undergo laboratory tests to ensure your body responds adequately to the medication and to monitor any potential side effects. The tests outlined below can help you do so.First, routine blood tests measure the level of malaria infection in your body, which helps your doctor assess whether the dosage of these drugs should be adjusted. These tests also examine your liver and kidney function to ensure they can handle the medication without undue stress. Moreover, they evaluate your blood cell count, including red and white cells, to identify any abnormalities. Secondly, the consistent monitoring of vital signs such as blood pressure, heart rate, and body temperature is crucial in identifying any potential adverse reactions to the medication. Thirdly, periodic assessments of your peripheral blood picture and electrolytes within your body help ensure you sustain optimal health while treating malaria. These tests serve a vital purpose in detecting any hidden complications, such as kidney dysfunction or electrolyte imbalances, which are potential side effects of the medication. In conclusion, scheduling laboratory tests while taking Artemether 20mg and Lumefantrine 120mg is vital to closely monitor your health and ensure the medication works effectively according to your body's response. These tests are an invaluable tool to identify potential risks and adverse reactions, allowing your healthcare provider to take any necessary corrective steps, thus ensuring a more controlled recovery from malaria.