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Arceva (40/240mg) 8 Tablets

Arceva (40/240mg) 8 Tablets

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  • Manufacturer SAMI Pharmaceuticals (Pvt.) Ltd.
  • Generic Name

    Artemether 40mg, Lumefantrine 240mg

Healthwire Pharmacy Ratings & Reviews (1500+)

4.9/ 5
Rs. 468.5 Rs. 503.76 6% OFF
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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • Dosage
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Control Drug
  • Quick Tips, if any
  • Description

    Artemether and Lumefantrine are both active components in the Artemether 40mg, Lumefantrine 240mg Tablet, and they work synergistically to treat malaria. Artemether, a derivative of artemisinin, acts rapidly by disrupting the parasite's digestive vacuole and inhibiting the biocrystallization of heme, which is toxic to the Plasmodium parasite. This process leads to the destruction of the parasite's membrane and ultimately kills the parasite in its erythrocytic stage. Lumefantrine, on the other hand, is a slow-acting component that has a long half-life and acts by inhibiting the Plasmodium parasite's vital functions, such as protein synthesis and metabolic processes. Together, the combination of artemether and lumefantrine provides a potent and effective treatment for malaria by attacking the parasite at different stages of its life cycle.

  • Ingredients

    Artemether 40mg, Lumefantrine 240mg

  • Drug Class

    Antimalarial medication

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Artemether 40mg, Lumefantrine 240mg Tablet:

    • Used for treating uncomplicated malaria caused by Plasmodium falciparum.
    • Used to kill the malaria parasites in the blood, offering relief from symptoms and preventing further complications.
    • Used as a combination therapy, with Artemether eliminating most parasites and Lumefantrine removing any remaining parasites.
    • Used to prevent the recurrence of malaria symptoms.
    • Used for patients who cannot tolerate other antimalarial medications.
    • Used under medical supervision, with dosage and duration tailored to the patient's needs.
    • Used as part of a comprehensive malaria treatment plan, including symptom management and preventive measures.
  • Dosage

    To be taken as per doctor's prescription

  • In case of Overdose

    In the case of an overdose of Artemether 40mg and Lumefantrine 240mg Tablet, individuals may experience an increase in the severity of common side effects such as dizziness, headache, and gastrointestinal issues. More serious effects might include an irregular heartbeat, seizures, or severe allergic reactions. Promptly seek medical advice, and inform the healthcare professional of the specific medication and dosage taken. They will provide guidance on the necessary steps to manage the overdose effectively and ensure appropriate treatment.

  • Missed Dose

    In the case of a missed dose of Artemether 40mg and Lumefantrine 240mg Tablet, it is important to take the medication as soon as possible. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. However, if you miss multiple doses, consult your healthcare provider for guidance, as they may advise you to restart the medication or provide alternative instructions to ensure the treatment's effectiveness.

  • How To Use

    To take Artemether 40mg and Lumefantrine 240mg Tablet, swallow the tablet whole with a glass of water, preferably after a meal, following the dosing schedule provided by your healthcare professional.

  • When Not to Use

    Here are the conditions and situations when Artemether 40mg, Lumefantrine 240mg Tablet should not be used:

    • Avoid if you have a known allergy or hypersensitivity to artemether, lumefantrine, or any other components of the medication.
    • Not recommended for patients with severe liver impairment or liver disease.
    • Should not be used in patients with a history of prolonged QT interval or cardiac arrhythmias.
    • Contraindicated in patients with severe gastrointestinal disorders, as it may affect drug absorption.
    • Not suitable for individuals with a history of seizures or epilepsy.
    • Avoid if you have a known deficiency of an enzyme called glucose-6-phosphate dehydrogenase (G6PD).
    • Should not be used as a standalone treatment for severe malaria; it is recommended in combination with other antimalarial drugs.
    • Not recommended for pregnant women, especially during the first trimester, unless the potential benefits outweigh the risks.
    • Avoid in breastfeeding women, as the drug may pass into breast milk and affect the infant.
  • Side Effects

    The side effects of Artemether 40mg, Lumefantrine 240mg Tablet may include:

    • Nausea and vomiting.
    • Diarrhea.
    • Dizziness or vertigo.
    • Loss of appetite.
    • Muscle or joint pain.
    • Cough.
    • Increased heart rate (tachycardia).
    • Itching or rash.
  • Precautions & Warnings

    Following are the precautions and warnings for Artemether 40mg, Lumefantrine 240mg Tablet:

    • This medication should not be used in patients with a known allergy to artemether, lumefantrine, or any other ingredients in the tablet.
    • Close monitoring of liver function is necessary during treatment, especially in patients with pre-existing liver conditions.
    • Patients with a history of epilepsy or other seizure disorders should exercise caution as this medication may lower the seizure threshold.
    • Not recommended for use during pregnancy, especially in the first trimester, unless the potential benefits outweigh the risks.
    • Breastfeeding women should consult their doctor as it is unknown if the drug passes into breast milk.
    • Patients should complete the full course of treatment to ensure the effective clearance of the infection and to prevent the development of resistance.
    • Artemether-lumefantrine should be used with caution in patients with severe gastrointestinal disorders as it may exacerbate gastrointestinal symptoms.
  • Drug Interactions

    Following are the drug interactions for Artemether 40mg, Lumefantrine 240mg Tablet:

    • Concomitant use with other antimalarial drugs like chloroquine or mefloquine can lead to reduced effectiveness and increased parasite resistance.
    • Rifampicin, a potent enzyme inducer, can decrease the plasma concentrations of lumefantrine, potentially reducing the effectiveness of the treatment.
    • The absorption of lumefantrine may be significantly reduced when co-administered with metoclopramide, a common drug used for nausea and vomiting.
    • Anticonvulsant medications such as phenytoin and carbamazepine can lower the effectiveness of artemether-lumefantrine by increasing its metabolism.
    • Antiretroviral protease inhibitors (e.g., ritonavir) can increase lumefantrine levels, requiring careful monitoring to avoid potential toxicity.
    • Co-administration with efavirenz, a non-nucleoside reverse transcriptase inhibitor, may reduce the effectiveness of lumefantrine due to decreased drug levels.
    • Certain antibiotics like rifabutin can decrease lumefantrine exposure, potentially leading to treatment failure.
  • Food Interactions

    Following are the food interactions for Artemether 40mg, Lumefantrine 240mg Tablet:

    • Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of the medication, leading to increased drug levels in the body.
    • Fatty meals can enhance the absorption of Artemether and Lumefantrine, ensuring better bioavailability. Consider taking the medication with a fatty meal for improved effectiveness.
    • Avoid excessive alcohol consumption as it may increase the risk of side effects such as dizziness and gastrointestinal issues.
    • Spicy foods are not recommended while taking this medication as they may irritate the stomach and potentially worsen gastrointestinal side effects.
    • Dairy products, especially high-fat dairy, can affect the absorption of the medication. Consider separating dairy intake from medication by a few hours to ensure optimal absorption.
    • Caffeine intake should be monitored as it may increase the risk of side effects like nervousness, insomnia, and palpitations.
    • Avoid consuming large amounts of Vitamin K-rich foods (e.g., leafy greens) as Artemether and Lumefantrine may interfere with vitamin K metabolism, affecting blood clotting.
    • Ensure a balanced diet to maintain overall health and support the medication's effectiveness.
  • Storage/Disposal

    Artemether 40mg, Lumefantrine 240mg Tablets should be stored in a cool and dry place, preferably at room temperature, away from sunlight and moisture. Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain their integrity. It is crucial to avoid exposing the medication to heat, so steer clear of storage near ovens or heaters. Regularly check the expiration date, and dispose of any unused or expired tablets responsibly. Proper disposal methods should be followed; do not flush or pour them down the drain. Consult your pharmacist or healthcare professional for guidance on safe disposal practices. Keep the medication securely stored, out of children's reach, to prevent accidental consumption.

  • Control Drug

    No

  • Quick Tips, if any

    Following are the quick tips for Artemether 40mg, Lumefantrine 240mg Tablet:

    • Take the tablet as directed by your doctor, usually once a day for 3 consecutive days.
    • Swallow the tablet whole with a full glass of water, preferably after a meal.
    • Complete the full course of medication as prescribed, even if you feel better after a few doses.
    • Avoid taking antacids or dairy products within 1 hour of taking this medicine.
    • Inform your doctor if you have any liver or kidney issues before starting this medication.
    • Store the tablets in a cool, dry place, away from direct sunlight and moisture.
    • Do not share this medication with others, even if their symptoms appear similar.

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