ARIXTRA INJ 2.5MG 0.5ML

The mechanism of action of Fondaparinux Sodium is specifically designed to inhibit factor Xa, a key enzyme in the coagulation cascade. By binding to factor Xa, it blocks the conversion of prothrombin to thrombin, thereby preventing the formation of fibrin clots. This action effectively inhibits thrombus development without directly affecting platelet function. Fondaparinux selectively targets factor Xa, offering a targeted approach to anticoagulation therapy.

Fondaparinux Sodium 5MG

Anticoagulant

Injection

The following are the uses of Fondaparinux Sodium 5MG Injection:

• Used for preventing blood clots in patients undergoing knee, hip, or abdominal surgeries.
• Used to treat blood clots in the lungs (pulmonary embolism) and legs (deep vein thrombosis).
• Used for long-term prevention of blood clots in cancer patients.
• Used for reducing the risk of blood clots in patients with restricted mobility.
• Used as an alternative to heparin in patients with certain medical conditions.
• Used to prevent blood clots during hemodialysis.
• Used for its anti-inflammatory properties in certain vascular conditions.

In the case of an overdose of Fondaparinux Sodium 5MG Injection, prompt medical attention is required. Symptoms may include excessive bleeding, prolonged clotting time, and potential bruising or hematomas. Treatment should focus on managing bleeding complications and supporting vital functions. Medical professionals should closely monitor the patient's coagulation status and provide appropriate interventions to control bleeding and stabilize the patient's condition.

In the case of a missed dose of Fondaparinux Sodium 5MG Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your medication schedule and ensure the best treatment outcome.

To administer Fondaparinux Sodium 5MG Injection, carefully remove the outer packaging, attach the provided syringe to the vial, draw out the prescribed dose, and inject it subcutaneously into the abdomen or thigh as directed by your healthcare professional, ensuring the injection site is clean and dry.

Following are the conditions when Fondaparinux Sodium 5MG Injection should not be used:

• Should not be used in patients with known allergies or hypersensitivity to Fondaparinux or any of its components.
• Contraindicated in patients with active major bleeding or a high risk of bleeding.
• Not recommended for individuals with severe kidney disease or end-stage renal disease.
• Should not be used in patients with heparin-induced thrombocytopenia (HIT) or a history of HIT.
• Contraindicated during pregnancy, especially during cesarean section or other surgical procedures.
• Not suitable for patients with severe blood disorders or a low platelet count.
• Should not be used in patients with an indwelling catheter in the spine or other similar procedures.
• Contraindicated in patients with uncontrolled high blood pressure.

The side effects of Fondaparinux Sodium 5MG Injection may include:

• Bleeding or easy bruising
• Injection site reactions (pain, redness, swelling)
• Fever
• Allergic reactions (rash, itching, hives)
• Thrombocytopenia (low platelet count)
• Increased blood pressure
• Hepatic (liver) abnormalities
• Localized skin necrosis (tissue damage) at the injection site

Following are the precautions and warnings for Fondaparinux Sodium 5MG Injection:

• Do not use if you are allergic to Fondaparinux or any other ingredients in the injection.
• Caution is advised for patients with a history of bleeding disorders, as it may increase the risk of bleeding.
• Close monitoring is required for patients with severe kidney disease, as dosage adjustments may be necessary.
• Not recommended for patients with active major bleeding or uncontrolled blood pressure.
• Patients undergoing spinal/epidural anesthesia or spinal puncture should be closely monitored for signs of spinal hematoma.
• Elderly patients may be more susceptible to bleeding risks, so caution is advised.
• Fondaparinux should be used with caution in obese patients, as proper dosing is essential.

Following are the drug interactions for Fondaparinux Sodium 5MG Injection:

• Thrombolytic agents, glycoprotein IIb/IIIa inhibitors, and other anticoagulants can increase the risk of bleeding when used concurrently.
• Non-steroidal anti-inflammatory drugs (NSAIDs) may enhance the risk of bleeding, and close monitoring is necessary.
• Platelet inhibitors like clopidogrel and aspirin also intensify the risk of bleeding.
• Fondaparinux should be used cautiously with drugs affecting hemostasis, such as thrombin inhibitors.
• Medications that alter renal function may influence the elimination of Fondaparinux, requiring dosage adjustments.
• Drugs that significantly affect platelet function may further increase the risk of bleeding.
• Patients taking other medications that increase the risk of spinal/epidural hematoma, such as anti-platelet agents, should be closely monitored.

Following are the food interactions for Fondaparinux Sodium 5MG Injection:

• Avoid alcohol consumption during treatment as it can increase the risk of bleeding complications.
• Grapefruit and grapefruit juice should be consumed with caution as they may interact with Fondaparinux, affecting its metabolism and potentially altering its effectiveness.
• Avoid high-fat meals as they can decrease the absorption of Fondaparinux, reducing its effectiveness.
• Foods rich in vitamin K like spinach, kale, and broccoli should be consumed in moderation as vitamin K can counteract the anticoagulant effect of Fondaparinux.
• Garlic, ginger, and ginkgo supplements may increase the risk of bleeding when taken with Fondaparinux.
• Avoid cranberry juice as it may affect the anticoagulant effect of Fondaparinux.
• Consult your healthcare provider about any herbal supplements or natural remedies you are taking, as some may interact with the medication.
• Always follow dietary recommendations provided by your doctor to ensure the medication's effectiveness.

Fondaparinux Sodium 5MG Injection should be stored in a controlled environment, preferably at room temperature between 20-25°C (68-77°F), in its original packaging to maintain stability. Protect it from excessive heat, direct sunlight, and moisture to ensure its effectiveness. Always check the expiration date before use and discard any expired medication. When disposing of unused or expired injections, do not flush or pour them into drainage systems. Instead, follow local guidelines or consult a healthcare professional for appropriate disposal methods to minimize environmental impact. Keep the medication out of children's reach to prevent accidental exposure.

Following are the quick tips for Fondaparinux Sodium 5MG Injection:

• Administer the injection as directed by your doctor; accuracy is crucial.
• Ensure the injection is given subcutaneously as instructed.
• Confirm the dose is correct before administration.
• Dispose of used needles and syringes safely.
• Do not inject if the solution is cloudy or discolored.
• Inform your doctor if you have kidney problems or are pregnant/breastfeeding.
• Store the medication as directed, away from children.
• Seek immediate medical attention if severe bleeding occurs.