Aromasin (25mg) 15 Tablets

Exemestane 25mg Tablet primarily works by acting as an irreversible, steroidal aromatase inhibitor. It specifically and selectively binds to the aromatase enzyme, which is responsible for the production of estrogen in the body. Upon binding, exemestane forms a permanent, covalent bond with the aromatase enzyme, leading to its deactivation. This inhibition of aromatase results in a significant reduction in estrogen levels, particularly in postmenopausal women, as aromatase is the primary source of estrogen production in this population. By suppressing estrogen production, exemestane effectively blocks the growth and proliferation of hormone-dependent breast cancer cells, making it an important therapeutic agent in the treatment of hormone receptor-positive breast cancer.

Exemestane 25mg

Aromatase inhibitor.

Tablet

The following are the uses of Exemestane 25mg Tablet:

• Used for treating breast cancer in postmenopausal women, particularly hormone-receptor-positive breast cancer.
• Used to prevent the production of estrogen in the body, which can fuel certain types of breast cancer growth.
• Effective in reducing the risk of cancer recurrence after initial treatment.
• Helps manage advanced or metastatic breast cancer that has not responded to other treatments.
• Used as an adjuvant therapy after surgery to lower the chances of cancer returning.
• Can be given to women with early-stage breast cancer to improve survival rates.
• Provides relief from symptoms and slows down the progression of the disease.
• Used in specific cases where breast cancer is dependent on hormones for growth.

In the case of an overdose of Exemestane 25mg Tablets, it is important to recognize the potential risks. Symptoms may include severe nausea, vomiting, and dizziness. If an overdose is suspected, immediate action should be taken. Contact a healthcare professional or a poison control center for guidance and seek medical assistance promptly. They will provide specific instructions and ensure the necessary steps are taken to manage the overdose effectively.

In the case of a missed dose of Exemestane 25mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss several doses, contact your healthcare provider for advice, as they may recommend a temporary adjustment to your dosing regimen to ensure the medication's effectiveness. It's best to establish a routine to help you remember to take your medication at the same time each day.

To take Exemestane 25mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the exact dosage instructions provided by your healthcare professional.

Exemestane 25mg Tablet should not be used in the following conditions:

• Allergic reactions • Patients with a known allergy to Exemestane or any of its ingredients should avoid this medication.
• Pregnancy • Contraindicated in pregnant women as it can cause harm to the developing fetus.
• Breastfeeding • Not recommended for women who are breastfeeding, as it may pass into breast milk.
• Liver disease • Patients with severe liver impairment should not take this medication.
• Hypersensitivity • Should not be used if the patient has a history of severe hypersensitivity reactions to similar medications.
• Estrogen-dependent tumors • This medication is not suitable for individuals with estrogen-dependent tumors, such as certain types of breast cancer.

The side effects of Exemestane 25mg Tablet may include:

• Hot flashes or sweating
• Fatigue or tiredness
• Joint pain or stiffness
• Nausea or vomiting
• Headache
• Increased risk of bone fractures (due to lowered estrogen levels)
• Mood changes or depression
• Weight gain or fluid retention
• Insomnia or difficulty sleeping
• Decreased appetite or taste changes
• Dizziness or lightheadedness

Following are the precautions and warnings for Exemestane 25mg Tablet:

• Not recommended for individuals with a known hypersensitivity or allergy to Exemestane or any of its ingredients.
• Patients with liver or kidney disease should use with caution and under medical supervision, as dose adjustments may be necessary.
• Exemestane may cause bone loss, so regular monitoring of bone density is advised, especially in postmenopausal women.
• Can increase the risk of cardiovascular events; patients with a history of cardiovascular disease should be closely monitored.
• May cause fatigue and dizziness, patients should avoid driving or operating heavy machinery if affected.
• Not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks.
• Elderly patients may be more susceptible to side effects and should be monitored closely.

Following are the drug interactions for Exemestane 25mg Tablet:

• It may reduce the effectiveness of hormonal contraceptives, so alternative methods of contraception are recommended.
• Avoid concurrent use with estrogen-containing medications, as they can counteract the effects of Exemestane.
• Exemestane can decrease the metabolism of drugs metabolized by CYP3A4, leading to increased levels of these drugs, including certain calcium channel blockers and some antiarrhythmics.
• The efficacy of tamoxifen may be reduced when taken with Exemestane, as it can inhibit its active metabolite formation.
• Rifampicin, a strong CYP3A4 inducer, can decrease Exemestane plasma concentrations and may reduce its effectiveness.
• Co-administration with warfarin or other anticoagulants requires monitoring of coagulation parameters due to potential increased bleeding risk.
• Drugs that increase gastric pH, such as proton pump inhibitors, may reduce the absorption of Exemestane, potentially impacting its effectiveness.
• Caution is advised when combining with other CYP3A4 inhibitors, as it may lead to increased Exemestane levels and potential side effects.

Following are the food interactions for Exemestane 25mg Tablet:

• Avoid grapefruit and grapefruit juice as they can inhibit the metabolism of Exemestane, leading to increased drug levels in the body and potentially raising the risk of side effects.
• Limit alcohol consumption as it may increase the risk of liver damage, especially when used for long-term treatment.
• Vitamin E supplements should be used with caution as high doses might interfere with Exemestane's effectiveness.
• High-fat meals may slightly increase the absorption of Exemestane, but this effect is not clinically significant.
• Avoid excessive consumption of foods high in vitamin A and beta-carotene, as Exemestane may increase their levels in the body.
• Ensure adequate calcium and vitamin D intake as Exemestane can lead to reduced bone mineral density.
• Maintain a balanced diet to support overall health and manage potential side effects like weight gain and lipid changes.
• No specific food restrictions are required, but a healthy diet is recommended during Exemestane therapy.

Exemestane 25mg Tablets should be stored in a cool and dry place, preferably in their original container, away from direct sunlight, moisture, and heat. It is crucial to maintain a stable room temperature for optimal storage conditions. Do not refrigerate or freeze the tablets as this may affect their potency. Always check the expiration date before using the medication, and discard any expired or unused tablets appropriately. When disposing of the medication, avoid flushing or pouring it down the drain; instead, consult your pharmacist or local waste disposal guidelines for safe disposal methods. Keep the tablets out of children's reach to prevent accidental consumption.

Following are the quick tips for Exemestane 25mg Tablet:

• Consult your doctor before starting this medication and provide a complete medical history.
• Take the tablet as directed by your doctor, typically once daily after a meal.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Maintain consistency by taking the tablet at the same time each day.
• Do not miss doses; if you miss one, take it as soon as you remember, unless it's almost time for the next dose.
• Inform your doctor about all medications and supplements you're taking to avoid potential interactions.
• Store the tablets at room temperature, away from light and moisture, and keep them out of reach of children.