ARTEDOXIN P TAB (6+2)

Artesunate 50mg tablets primarily act by interfering with the parasite's mitochondrial membrane, specifically targeting the Plasmodium species responsible for malaria. This interference leads to the production of reactive oxygen species and free radicals, which cause severe damage to the parasite's cellular components, ultimately resulting in its destruction. The artesunate molecule undergoes metabolic activation within the body, forming reactive intermediates that bind to specific parasite proteins, disrupting vital cellular processes and inhibiting the growth and replication of the Plasmodium parasite. This mechanism of action makes artesunate highly effective in treating malaria, particularly in severe cases or those caused by drug-resistant strains.

Artesunate 50mg

Antimalarial medication

Tablet

The following are the uses of Artesunate 50mg Tablet:

• Used for treating severe malaria, especially in cases of resistance to other antimalarial drugs.
• Used for rapidly reducing malaria parasite load in the blood.
• Used for managing severe malaria complications, such as cerebral malaria.
• Used for treating malaria in regions with high levels of drug resistance.
• Used as an alternative treatment when other antimalarials are not available or tolerated.
• Used in combination with other antimalarials for improved efficacy.
• Used for reducing the risk of malaria transmission in endemic areas.

In the case of an overdose of Artesunate 50mg Tablets, immediate medical intervention is necessary. Symptoms may include severe nausea, vomiting, and in extreme cases, organ failure. Quick action is vital, as an overdose can lead to life-threatening complications. Medical professionals should be contacted promptly to establish the severity of the overdose and administer appropriate treatment to counteract the effects of the excess medication. Timely response can significantly improve the chances of a successful recovery.

In the case of a missed dose of Artesunate 50mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have missed multiple doses, contact your healthcare provider for guidance on how to safely resume your medication and ensure the treatment remains effective.

To take Artesunate 50mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions when Artesunate 50mg Tablet should not be used:

• Must not be used in patients with a known allergy to Artesunate or other artemisinin-based compounds.
• Not suitable for individuals with severe liver disease or liver failure.
• Should not be used as a standalone treatment for severe malaria; it should be used in combination with other antimalarial drugs.
• Not recommended for patients with prolonged QT intervals or heart rhythm disorders.
• Contraindicated in individuals with a history of severe gastrointestinal disorders or who are at risk of severe vomiting.
• Should be avoided during pregnancy, especially in the first trimester, unless the potential benefits outweigh the risks.
• Not suitable for breastfeeding mothers, as it may pass into breast milk and harm the nursing infant.
• Not recommended for patients with a history of severe skin reactions to medications.
• Should be used with caution in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

The side effects of Artesunate 50mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Dizziness
• Headache
• Allergic reactions (such as rash, itching, or hives)
• Decreased appetite
• Abnormal liver function tests
• Palpitations

Following are the precautions and warnings for Artesunate 50mg Tablet:

• This medication is intended for the treatment of severe malaria and should only be used under medical supervision.
• Artesunate should not be used in patients with a known allergy to the drug or its components.
• Patients with a history of liver or kidney disease should use this medication with caution and under medical supervision, as these conditions may affect the metabolism and elimination of the drug.
• Close monitoring of liver function is necessary during treatment, as Artesunate can cause liver-related side effects.
• Artesunate may cause dizziness or drowsiness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• It is essential to complete the full course of treatment as prescribed, even if symptoms improve, to ensure complete eradication of the malaria parasite.
• Pregnant and breastfeeding women should consult their doctor before taking Artesunate, as the risks and benefits should be carefully considered.
• Keep this medication out of reach of children and store it in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Artesunate 50mg Tablet:

• Artesunate can interact with other antimalarial drugs like chloroquine or mefloquine, leading to reduced effectiveness or increased side effects.
• Concomitant use with certain antibiotics, such as doxycycline or tetracycline, may result in decreased absorption of Artesunate.
• The effect of Artesunate may be reduced when taken with antacids containing calcium or magnesium. Separate dosing is recommended.
• Artesunate can increase the risk of bleeding when taken with anticoagulants like warfarin or heparin. Close monitoring is required.
• Interactions with immunosuppressants like cyclosporine or tacrolimus can alter drug levels and increase toxicity.
• Caution is advised when combining Artesunate with anti-seizure medications, as it may affect their metabolism and efficacy.
• Artesunate may reduce the efficacy of hormonal contraceptives, requiring additional contraceptive measures.

Following are the food interactions for Artesunate 50mg Tablet:

• Artesunate may interact with grapefruit, as grapefruit juice can affect the absorption and metabolism of the drug, potentially increasing its levels in the blood. Avoid consuming grapefruit or grapefruit products while on this medication.
• Alcohol consumption is generally not recommended during malaria treatment. Alcohol may reduce the effectiveness of Artesunate and increase the risk of side effects, particularly liver-related issues.
• Fatty foods may slightly delay the absorption of Artesunate, but this is not a significant concern. However, for faster absorption, it is best to take the tablet on an empty stomach or with a light meal.
• Dairy products, especially milk, might potentially interact with Artesunate, leading to reduced absorption. Consider separating milk intake from Artesunate dosing by a few hours.
• Avoid high-fat meals as they can slow down the absorption of Artesunate, potentially affecting its effectiveness.
• Caffeinated beverages like coffee and tea might potentially stimulate the liver, increasing the metabolism of Artesunate, which could lower its effectiveness.
• Always follow the advice of your healthcare provider regarding dietary restrictions or specific food interactions while taking Artesunate.
• No significant food interactions have been reported with Artesunate, but maintaining a balanced diet is essential for overall health during treatment.

Artesunate 50mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, ensuring it remains out of reach of children and pets. Maintain a consistent room temperature, avoiding excessive heat, moisture, or direct sunlight as these conditions can degrade the medication. Always keep the tablets in their original packaging, tightly sealed, to preserve their integrity and prevent contamination. Regularly check the expiration date, and dispose of expired or unused tablets promptly. When disposing of Artesunate tablets, do not flush them or throw them into the trash; instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for guidance on safe and environmentally responsible disposal methods. Proper storage and disposal practices are crucial to maintaining the effectiveness of the medication and ensuring the safety of both the user and the environment.

Following are the quick tips for Artesunate 50mg Tablet:

• Take the tablet as directed by your doctor, typically once daily or as prescribed.
• Consume the tablet orally, preferably with a glass of water.
• Ensure you complete the full course of medication, even if you feel better.
• Maintain a consistent time for taking the tablet each day.
• Store the medication in a cool, dry place, away from direct sunlight.
• Inform your doctor about any other medications you are taking to avoid potential interactions.
• Do not crush or chew the tablet; swallow it whole for optimal absorption.
• Seek immediate medical attention if you experience severe side effects or allergic reactions.