Artem (80mg/1ml) 6 Ampoule Injections

Artemether, the active component in the Artemether 80mg/1ml injection, exhibits a rapid and potent mechanism of action against malaria parasites. It selectively targets the parasite's mitochondria, disrupting their energy production and membrane potential. Artemether rapidly induces the production of reactive oxygen species and oxidative stress within the parasite, leading to rapid parasite death. This mechanism is particularly effective against the asexual forms of the Plasmodium parasite, including those that cause the most severe and life-threatening forms of malaria. The drug's ability to rapidly clear parasites from the bloodstream makes it a valuable component in the treatment of malaria, especially in combination with other antimalarial agents.

Artemether 80mg/1ml

Antimalarial

injection

The following are the uses of Artemether 80mg/1ml injection:

• Used for treating severe malaria, especially in cases where the parasite has become resistant to other antimalarial drugs.
• Used for rapid reduction of high parasite load in the blood, effectively killing the malaria-causing organisms.
• Used for managing cerebral malaria, a life-threatening complication, by reducing parasite count in the brain.
• Used for treating acute and life-threatening symptoms associated with malaria, such as fever and chills.
• Used for preventing the progression of malaria, especially in regions with high drug-resistant parasite prevalence.
• Used for providing quick relief in severe malaria cases, improving overall patient health and recovery.
• Used for its fast-acting property, allowing for prompt medical intervention in critical malaria situations.

To be taken as per doctor's prescription

In the case of an overdose of Artemether 80mg/1ml injection, prompt medical attention is necessary. Symptoms may include an increase in existing side effects such as nausea, vomiting, and dizziness, or more severe reactions like difficulty breathing and seizures. Treatment involves managing these symptoms and providing supportive care. It is crucial to contact a healthcare professional or go to the nearest emergency department immediately if an overdose is suspected. Timely intervention can significantly impact the patient's recovery.

In the case of a missed dose of Artemether 80mg/1ml injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not administer a double dose to make up for a missed one. It is crucial to follow the prescribed dosing regimen to ensure the effectiveness of the treatment. If you have any concerns or questions about missed doses, consult your healthcare provider for guidance.

To administer Artemether 80mg/1ml injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the entire contents of the prefilled syringe intramuscularly, ensuring proper needle disposal afterward.

Following are the conditions when Artemether 80mg/1ml injection should not be administered:

• Must not be used in individuals with a known allergy to Artemether or any other artemisinin-based compounds.
• Contraindicated in patients with a history of prolonged QT interval or heart rhythm disorders.
• Not suitable for individuals with severe liver impairment or active liver disease.
• Should be avoided in patients with severe kidney disease or those undergoing dialysis.
• Not recommended for pregnant women, especially during the first trimester, unless the potential benefits outweigh the risks.
• Should not be used in newborns, especially those with low birth weight or premature infants.
• Contraindicated in patients with known glucose-6-phosphate dehydrogenase (G6PD) deficiency.
• Not suitable for individuals with a history of severe seizures or epilepsy.

The side effects of Artemether 80mg/1ml injection may include:

• Nausea and vomiting.
• Itching or rash.
• Diarrhea.
• Dizziness.
• Pain or swelling at the injection site.
• Abnormal liver function tests.
• Decreased appetite and weight loss.
• In rare cases, allergic reactions may occur.

Following are the precautions and warnings for Artemether 80mg/1ml Injection:

• Avoid use in patients with known hypersensitivity to artemether or any other components of the injection.
• Not recommended for use during the first trimester of pregnancy unless the potential benefit justifies the potential risk to the fetus.
• Use with caution in patients with a history of liver or kidney impairment, as dose adjustments may be necessary.
• Monitor for signs of severe allergic reactions or anaphylaxis; if symptoms occur, discontinue immediately and seek medical attention.
• May cause dizziness, headache, or confusion; avoid driving or operating heavy machinery until the effects are known.
• Caution is required in patients with a history of arrhythmias or other heart conditions, as artemether may have effects on the cardiovascular system.
• Regular monitoring of blood counts is recommended, as artemether can cause hematologic side effects like leukopenia or thrombocytopenia.
• Not recommended for the treatment of severe or complicated malaria when intravenous artesunate is more appropriate.
• Use with caution in elderly patients, as they may be more susceptible to side effects.
• Avoid alcohol during treatment, as it may increase the risk of side effects.
• If symptoms worsen or do not improve after treatment, seek immediate medical attention.

Following are the drug interactions for Artemether 80mg/1ml injection:

• Artemether may reduce the effectiveness of antimalarial drugs like chloroquine, mefloquine, and quinine when used together.
• Concomitant use with other medications metabolized by the liver's CYP3A4 enzyme can lead to increased levels of those drugs, e.g., certain calcium channel blockers, antifungal agents, and HIV protease inhibitors.
• Caution is advised when combining Artemether with drugs that prolong the QT interval, such as antiarrhythmics or certain antipsychotics, due to the potential for cardiac arrhythmias.
• The effectiveness of Artemether may be reduced when used with rifampicin, a potent enzyme inducer.
• It can interact with antiretroviral drugs used in HIV treatment, potentially affecting the levels of both medications.
• Artemether may increase the risk of bleeding when taken with anticoagulants or antiplatelet drugs, requiring close monitoring.
• Use with other drugs that suppress bone marrow function should be monitored due to the potential for additive myelosuppression.

Following are the food interactions to consider with Artemether 80mg/1ml injection:

• Artemether is best absorbed when taken on an empty stomach, so it is recommended to avoid food or heavy meals before and after taking the injection.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Artemether, potentially leading to increased drug levels in the body.
• Alcohol consumption should be minimized or avoided as it may decrease the effectiveness of Artemether and increase the risk of side effects.
• Avoid high-fat meals as they can affect the absorption of Artemether, potentially reducing its efficacy.
• Caffeine-rich beverages like coffee and energy drinks may enhance the metabolism of Artemether, which could result in reduced drug levels and potentially impact its effectiveness.
• Avoid excessive consumption of green leafy vegetables and iron-rich foods as they can affect the absorption of Artemether.
• Always inform your healthcare provider about your dietary habits to ensure the optimal effectiveness of the medication.
• Generally, maintaining a balanced diet and staying well-hydrated is advisable when undergoing treatment with Artemether.

Artemether 80mg/1ml injection should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 20-25°C (68-77°F). Protect the injection vials from direct sunlight and moisture to ensure their integrity. Always keep the medication in its original packaging, tightly sealed, to prevent contamination and maintain its sterility. When disposing of unused or expired injections, do not flush or pour them down the drain; instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for appropriate methods. Keep the medication out of children's reach to prevent accidental exposure, as it is strictly for medical use under professional supervision.

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Following are the quick tips for Artemether 80mg/1ml injection:

• Administer the injection under medical supervision for safety and effectiveness.
• Ensure the injection is given intramuscularly or intravenously as directed by the healthcare professional.
• Do not inject if the solution appears cloudy or contains particles.
• Follow the prescribed dosage and duration of treatment as advised by your doctor.
• Inform your doctor about any other medications you are taking to avoid potential interactions.
• Store the injection at room temperature, away from direct sunlight and moisture.
• Dispose of any unused or expired medication properly, do not flush it down the toilet.
• In case of severe side effects or allergic reactions, seek immediate medical attention.