Artem Plus (30/180mg) 30ml Suspension

Artemether and Lumefantrine work synergistically to combat malaria. Artemether, a derivative of artemisinin, exerts its effect by disrupting the parasite's digestive vacuole, inhibiting the metabolism of the malaria parasite, and causing its rapid destruction. It primarily targets the early stages of the parasite's lifecycle, including the ring and trophozoite forms. Lumefantrine, a long-acting partner drug, reinforces this action by interfering with the parasite's energy production and inhibiting the synthesis of essential proteins, further weakening and eliminating the malaria parasites, particularly during their later stages of development.

Artemether 30mg, Lumefantrine 180mg

Antimalarial medication.

Suspension

The following are the uses of Artemether 30mg, Lumefantrine 180mg Syrup/Suspension:

• Used for the treatment of acute, uncomplicated Plasmodium falciparum malaria.
• Used to treat malaria in adults and children over 5kg in weight.
• Used when other antimalarial medications are not suitable or have failed.
• Used for its effectiveness against the parasite's life cycle stages.
• Used to reduce fever and improve symptoms quickly.
• Used to prevent the recurrence of malaria symptoms.
• Used as an alternative for patients who cannot tolerate oral tablets.

To be taken as per doctor's prescription

In the case of an overdose of Artemether 30mg and Lumefantrine 180mg Syrup/Suspension, immediate medical intervention is necessary. Symptoms may include severe nausea, vomiting, and in extreme cases, organ damage or failure. The severity of the reaction depends on the amount ingested, and medical professionals should be contacted promptly. Treatment involves managing symptoms and providing supportive care to prevent further complications. It is crucial to seek professional help quickly to ensure the best possible outcome.

In the case of a missed dose of Artemether 30mg and Lumefantrine 180mg Syrup/Suspension, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed with your treatment.

To administer Artemether 30mg and Lumefantrine 180mg Syrup/Suspension, shake the bottle well, draw the prescribed dose using the provided measuring device, and give it to the patient orally, following the dosage instructions provided by the healthcare professional for the duration of the treatment.

Following are the conditions/situations when Artemether 30mg and Lumefantrine 180mg Syrup/Suspension should not be used:

• Not recommended for individuals with a known allergy to Artemether, Lumefantrine, or any other similar antimalarial medications.
• Should not be administered to patients with a history of prolonged QT interval or heart rhythm disorders.
• Contraindicated in individuals with severe liver impairment or active liver disease.
• Not suitable for patients with severe gastrointestinal disorders that affect drug absorption.
• Should be avoided in newborns and infants under 3 months of age due to potential risks.
• Not recommended for individuals with a known deficiency of an enzyme called G6PD (glucose-6-phosphate dehydrogenase).
• Contraindicated during breastfeeding as it may pass into breast milk and harm the baby.

The side effects of Artemether 30mg and Lumefantrine 180mg Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Dizziness or vertigo
• Headache
• Fatigue and weakness
• Skin rashes or itching
• Altered taste sensation

Following are the precautions and warnings for Artemether 30mg, Lumefantrine 180mg Syrup/Suspension:

• Do not use if you are allergic to any of the ingredients, including artemether and lumefantrine.
• This medication should be used with caution in patients with liver or kidney disease, as it may require dosage adjustments.
• Avoid alcohol consumption during the treatment period as it may increase the risk of side effects.
• Patients should be monitored for any signs of neurotoxicity, such as dizziness, headache, or blurred vision, and medical advice should be sought if these occur.
• It is essential to complete the full course of treatment as prescribed, even if symptoms improve, to ensure complete eradication of the parasite.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as it may have potential risks to the fetus or infant.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Artemether 30mg, Lumefantrine 180mg Syrup/Suspension:

• Concomitant use with certain antiretroviral drugs like efavirenz, nevirapine, or ritonavir-boosted protease inhibitors can reduce the effectiveness of artemether-lumefantrine, leading to treatment failure.
• It may decrease the plasma concentrations of oral contraceptives, potentially reducing their effectiveness. Consider alternative or additional contraceptive methods during treatment.
• Artemether can increase the effects of anti-diabetic medications, leading to hypoglycemia. Monitor blood glucose levels closely.
• Co-administration with certain antibiotics like rifampicin or rifabutin can reduce the effectiveness of artemether-lumefantrine.
• Lumefantrine is metabolized by CYP3A4, and inhibitors of this enzyme (e.g., ketoconazole, clarithromycin) can increase its blood levels, potentially leading to adverse effects.
• The syrup may reduce the effectiveness of anti-seizure medications, such as phenytoin or carbamazepine, by affecting their metabolism.
• Concurrent use with certain anti-malaria drugs like mefloquine or chloroquine may alter the therapeutic response and increase the risk of side effects.

Following are the food interactions for Artemether 30mg, Lumefantrine 180mg Syrup/Suspension:

• Fat-rich meals can significantly increase the absorption of Artemether and Lumefantrine, potentially leading to higher blood concentrations. Consuming a high-fat meal with the medication may result in increased drug exposure.
• Grapefruit and grapefruit juice should be avoided as they can inhibit the CYP3A4 enzyme, which is involved in the metabolism of Artemether. This inhibition can lead to elevated drug levels in the blood, increasing the risk of side effects.
• Alcohol consumption should be avoided as it may reduce the effectiveness of the medication and increase the risk of adverse effects, particularly related to the central nervous system.
• Consuming foods rich in piperine, such as black pepper, may increase the bioavailability of both Artemether and Lumefantrine. This can result in higher drug levels in the body.
• The medication should be taken with food to enhance the absorption of Lumefantrine, ensuring optimal treatment outcomes.
• Dairy products, especially those high in fat, might interact with the medication. It is advisable to separate the medication and dairy consumption by a few hours to minimize potential interactions.
• Avoid excessive consumption of Seville oranges and their products, as they contain compounds that can affect drug metabolism, potentially altering the effectiveness of the medication.
• While not a specific food interaction, maintaining a consistent and balanced diet is essential during the treatment to support overall health and recovery.

Artemether 30mg, Lumefantrine 180mg Syrup/Suspension should be stored in a controlled environment, preferably at room temperature between 20-25°C (68-77°F), away from direct sunlight and moisture. Keep the syrup tightly sealed in its original container to maintain its integrity and prevent contamination. It is crucial not to freeze the medication. Always refer to the expiry date on the packaging and dispose of any unused or expired syrup responsibly; do not discard it in wastewater or household garbage. When disposing of the medication, follow local guidelines or consult a healthcare professional for appropriate methods. Ensure that the medication is stored safely, out of the reach of children, to prevent accidental consumption.

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Following are the quick tips for Artemether 30mg, Lumefantrine 180mg Syrup/Suspension:

• Ensure you take the syrup as directed by your doctor for best treatment outcomes.
• Before each use, shake the bottle vigorously to mix the medication thoroughly.
• Administer the syrup with a glass of water; avoid tea, coffee, or dairy products for better absorption.
• Maintain a consistent schedule for taking the medication, preferably at the same time daily.
• If stomach discomfort occurs, consider taking the syrup with food or post-meals.
• Store the medication safely, away from children's reach, to prevent accidental ingestion.
• Do not hesitate to consult your healthcare provider for any queries or concerns regarding your treatment.