Artequine (40/320mg) 8 Tablets

Dihydroartemisinin and Piperaquine Phosphate Tablet is a combination medication used to treat malaria. Dihydroartemisinin, derived from artemisinin, exerts its antimalarial effects by targeting the parasite's endoperoxides, which undergo cleavage within the parasite, generating reactive oxygen species that damage the parasite's proteins and lipids, ultimately leading to their destruction. Piperaquine, on the other hand, interferes with the parasite's DNA replication and transcription by inhibiting the plasmodial enzyme plasmodial topoisomerase II, effectively preventing the replication and spread of the malaria parasite within the body. This dual mechanism of action makes the combination highly effective in treating malaria caused by various Plasmodium species.

Antimalarial Combination

Tablet

The following are the uses of Dihydroartemisinin, Piperaquine Phosphate Tablet:

• Used for treating uncomplicated Plasmodium falciparum malaria
• Used to combat malaria parasites in the blood
• Used for reducing malaria-related fever and other symptoms
• Used for preventing the spread and replication of malaria parasites
• Used to manage and control malaria infections
• Used for its potent antimalarial properties
• Used to support recovery and prevent malaria recurrence

In the case of an overdose of Dihydroartemisinin, Piperaquine Phosphate Tablets, individuals may experience intensified side effects associated with the medication. These side effects can include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea, as well as potential neurological symptoms like dizziness, headaches, and in severe cases, seizures. Prompt medical attention is necessary to manage these symptoms effectively, and individuals should seek professional advice for appropriate treatment and monitoring.

In the case of a missed dose of Dihydroartemisinin, Piperaquine Phosphate Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. It is crucial to maintain a consistent dosing regimen, so if you miss a dose, consult your healthcare provider for guidance on how to adjust your medication schedule to ensure optimal treatment.

To take Dihydroartemisinin, Piperaquine Phosphate Tablets, swallow the prescribed number of tablets with water as directed by your healthcare provider, usually once a day, and follow the recommended dosage based on your age and medical condition.

Here are the conditions and situations when Dihydroartemisinin, Piperaquine Phosphate Tablet should not be used:

• Do not use if you are allergic to any of the active ingredients, Dihydroartemisinin or Piperaquine Phosphate, or any other related compounds.
• Contraindicated in patients with a history of prolonged QT interval or cardiac arrhythmias.
• Should not be used in patients with known severe liver or kidney impairment.
• Avoid using this medication if you have a history of seizures or epilepsy.
• Do not use if you are pregnant or breastfeeding, as the effects on the fetus and infant are not fully established.
• Not recommended for children weighing less than 11 lbs (5 kg).
• Should not be used in patients with known hypersensitivity or previous severe reactions to similar antimalarial drugs.
• Avoid using this medication if you have a blood disorder or low blood sugar levels.

The side effects of Dihydroartemisinin, Piperaquine Phosphate Tablet may include:

• Nausea and vomiting.
• Diarrhea.
• Abdominal pain.
• Dizziness or vertigo.
• Fatigue and weakness.
• Headache.
• Skin rashes or itching.
• Transient liver enzyme elevations.

Here are the precautions and warnings for Dihydroartemisinin, Piperaquine Phosphate Tablet:

• This medication is intended for the treatment of specific types of malaria and should not be used for any other condition without medical supervision.
• Patients with known allergies to artemisinin derivatives or piperaquine should not take this medication to avoid severe allergic reactions.
• Dihydroartemisinin, Piperaquine Phosphate Tablet may cause abnormal heart rhythms; patients with existing heart conditions should use it with caution and under medical supervision.
• It can cause liver problems; regular monitoring of liver function is necessary during treatment, especially for those with pre-existing liver conditions.
• Patients with severe gastrointestinal disorders may not absorb the medication properly, leading to reduced effectiveness.
• This medication may cause dizziness or blurred vision; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Pregnant and breastfeeding women should consult a healthcare professional before taking this medication, as its safety during pregnancy and breastfeeding is not fully established.
• Always take this medication as directed by your healthcare provider, and complete the full course of treatment to ensure effective eradication of the malaria parasite.

Following are the drug interactions for Dihydroartemisinin, Piperaquine Phosphate Tablet:

• Co-administration with strong CYP3A4 inducers (e.g., rifampicin, carbamazepine) may decrease plasma concentrations of piperaquine, potentially reducing its efficacy.
• Concomitant use of CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) can increase piperaquine levels, raising the risk of adverse effects.
• Piperaquine may enhance the QTc-prolonging effect of other drugs with similar cardiac effects, such as quinidine, sotalol, and methadone.
• Caution is advised when combining with other antimalarials, as drug interactions may occur, affecting efficacy and safety.
• The tablet may reduce the effectiveness of hormonal contraceptives, requiring additional contraceptive methods.
• Co-administration with certain anti-retroviral medications may affect piperaquine levels, necessitating close monitoring.
• Dihydroartemisinin may increase the effects of other drugs metabolized by CYP2B6 and CYP3A4 enzymes, requiring dosage adjustments.

Following are the food interactions to be aware of when taking Dihydroartemisinin, Piperaquine Phosphate Tablets:

• Avoid grapefruit and grapefruit juice as they can alter the effectiveness of the medication by affecting liver enzymes, potentially leading to increased drug levels in the body.
• Alcohol consumption should be minimized or avoided as it may increase the risk of liver-related side effects due to the additional burden on the liver.
• Fatty foods may slightly delay the absorption of the medication but are generally not a concern.
• Ensure adequate hydration and maintain a balanced diet to support overall health during the medication course.
• Certain dairy products may interfere with the absorption of the drug, so consider spacing out calcium-rich foods and supplements from medication intake.
• Vitamin K-rich foods like leafy greens may affect blood clotting, especially if you have a bleeding disorder or are taking blood thinners alongside this medication.
• Herbal supplements and certain foods with medicinal properties should be used with caution as they may interact, consult a healthcare professional for guidance.
• Always follow the dosage instructions provided by your healthcare provider for optimal efficacy and safety.

Dihydroartemisinin, Piperaquine Phosphate Tablets should be stored in a secure and dry location, preferably at room temperature, away from sunlight, moisture, and heat sources like radiators or stoves, as these conditions can degrade the medication. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent contamination. It is crucial to adhere to the expiration date on the package and properly dispose of any unused or expired tablets. Avoid flushing them down the toilet or sink; instead, consult your pharmacist or healthcare professional for appropriate disposal methods. Ensure the tablets are stored out of children's reach to prevent accidental consumption.

Following are the quick tips for Dihydroartemisinin, Piperaquine Phosphate Tablet:

• Take the tablet as directed by your doctor, typically as a single dose or as prescribed.
• Swallow the tablet whole with a full glass of water, preferably on an empty stomach.
• Ensure you complete the full course of medication, even if you feel better after a few doses.
• Maintain a consistent schedule for taking the tablet to maximize its effectiveness.
• Avoid taking antacids or medicines containing aluminum, magnesium, or calcium within 1-2 hours of this tablet.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• If you experience any severe side effects or allergic reactions, seek medical attention immediately.