Artesul (100mg) 9 Tablets

Artesul (100mg) 9 Tablets

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  • Manufacturer ZAFA PHARMACEUTICALS (PVT.) LTD.
  • Generic Name Sulfadoxine, Artesunate

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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Sulfadoxine, a sulfonamide antibiotic, acts by inhibiting the synthesis of folic acid in susceptible bacteria and parasites. It specifically targets the enzyme dihydropteroate synthase (DHPS), which is crucial for the production of folate, an essential component for DNA synthesis and cell growth. By disrupting folate metabolism, sulfadoxine interferes with the parasite's ability to replicate and survive. On the other hand, artesunate, a derivative of artemisinin, exerts its effect through the production of reactive oxygen species (ROS) that damage the parasite's proteins and lipids, leading to parasite death. Artesunate targets the parasite's mitochondria, causing rapid depletion of ATP, which is vital for the parasite's energy production and survival. This dual mechanism of action makes the combination of sulfadoxine and artesunate effective in treating malaria caused by susceptible strains of the parasite.

  • Ingredients

    Sulfadoxine, Artesunate
  • Drug Class

    Antimalarial

  • Dosage Form

    Tablet

  • Uses

    The following are the uses of Sulfadoxine, Artesunate Tablet:

    • Used for treating uncomplicated Plasmodium falciparum malaria
    • Used as a combination therapy for its effectiveness against malaria parasites
    • Used to reduce malaria transmission and manage drug resistance
    • Used in areas with high levels of chloroquine-resistant malaria
    • Used as an alternative treatment for pregnant women with malaria
    • Used to prevent and manage severe malaria cases
    • Used for rapid reduction of malaria parasite load
    • Used in combination with other antimalarial drugs for comprehensive treatment
  • In case of Overdose

    In the case of an overdose of Sulfadoxine and Artesunate Tablets, it is important to seek medical advice promptly. Symptoms of an overdose may include severe nausea, vomiting, abdominal pain, and in extreme cases, seizures or loss of consciousness. Treatment for overdose involves managing these symptoms and providing supportive care. Prompt medical intervention can help mitigate the risks associated with excessive medication intake.

  • Missed Dose

    In the case of a missed dose of Sulfadoxine, Artesunate Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, consult your healthcare provider for advice on how to safely resume your medication. It is crucial to maintain a consistent dosing schedule for the treatment's effectiveness.

  • How To Use

    To take the Sulfadoxine, Artesunate Tablet, swallow the tablet whole with water, preferably on an empty stomach, following the dosage instructions provided by your healthcare professional, typically as a single dose or as directed by your doctor.

  • When Not to Use

    Following are the conditions when Sulfadoxine, Artesunate Tablet should not be used:

    • Should not be used in individuals with a known allergy to Sulfadoxine, Artesunate, or other sulfonamide-derived medications.
    • Contraindicated in patients with severe liver or kidney disease.
    • Not recommended for infants under 6 months of age due to the risk of kernicterus.
    • Should be avoided in individuals with known glucose-6-phosphate dehydrogenase (G6PD) deficiency.
    • Contraindicated during the first trimester of pregnancy and in breastfeeding mothers.
    • Not suitable for individuals with a history of severe cutaneous reactions to other drugs.
    • Should not be used in patients with known folate deficiency or megaloblastic anemia.
    • Contraindicated in patients with known or suspected severe malaria caused by resistant parasites.
    • Should be used with caution and avoided in patients with a history of seizure disorders.
  • Side Effects

    The side effects of Sulfadoxine, Artesunate Tablet may include:

    • Nausea and vomiting.
    • Dizziness or a spinning sensation.
    • Diarrhea.
    • Loss of appetite.
    • Skin rashes or itching.
    • Fatigue and weakness.
    • Joint and muscle pain.
    • Changes in taste.
  • Precautions & Warnings

    Following are the precautions and warnings for Sulfadoxine, Artesunate Tablet:

    • This medication is not recommended for individuals with known allergies to sulfa drugs, sulfadoxine, or artesunate. An allergic reaction can be severe.
    • Patients with severe liver or kidney disease should exercise caution and consult a healthcare professional before use, as dosage adjustments may be necessary.
    • It is essential to complete the full course of treatment to ensure the effectiveness of the medication and prevent the development of drug-resistant parasites.
    • Artesunate may cause dizziness or drowsiness. Avoid activities that require alertness, such as driving or operating heavy machinery, until you know how this medication affects you.
    • Inform your doctor if you have a glucose-6-phosphate dehydrogenase (G6PD) deficiency, as artesunate can cause hemolysis in these individuals.
    • Do not take this medication if you are pregnant or breastfeeding unless advised by a healthcare professional, as it may have potential risks for the fetus or infant.
    • This medication may cause temporary loss of hair; it usually grows back after treatment is completed.
    • Keep this medication out of reach of children and pets.
  • Drug Interactions

    Following are the drug interactions for Sulfadoxine, Artesunate Tablet:

    • Concomitant use with other antimalarial drugs like chloroquine or mefloquine can increase the risk of adverse effects and may reduce the effectiveness of treatment.
    • Sulfadoxine may decrease the effectiveness of oral contraceptives, so alternative methods of contraception are recommended.
    • Artesunate can affect the metabolism of drugs processed by the liver, including some antiretrovirals and antifungal medications.
    • Co-administration with rifampicin may reduce the plasma concentrations of artesunate, potentially decreasing its therapeutic effect.
    • Theophylline levels may be increased when used with sulfadoxine, requiring close monitoring.
    • Drug interactions with antibiotics like trimethoprim-sulfamethoxazole can increase the risk of myelosuppression and other adverse effects.
    • Caution is advised when using with antacids, as they may reduce the absorption of artesunate.
  • Food Interactions

    Following are the food interactions for Sulfadoxine, Artesunate Tablet:

    • Avoid grapefruit and grapefruit juice as they may interfere with the metabolism of the drug, potentially increasing the levels of Artesunate in the body and raising the risk of side effects.
    • Alcohol consumption should be limited or avoided as it may increase the risk of liver-related side effects and may also decrease the effectiveness of the treatment.
    • Fatty meals can potentially reduce the absorption of Artesunate, so it is advisable to take the medication on an empty stomach or with a light meal.
    • Avoid cranberry juice as it may decrease the effectiveness of Sulfadoxine by affecting its absorption.
    • Dairy products, especially milk, can reduce the absorption of Sulfadoxine, so it is recommended to separate the medication and dairy intake by a few hours.
    • Vitamin C supplements or citrus fruits rich in vitamin C may increase the acidity of urine, which can affect the excretion of Artesunate.
    • Caffeine intake should be monitored as it may increase the heart rate and interact with the medication's effects on the cardiovascular system.
    • Avoid high-sodium foods as they may reduce the effectiveness of Sulfadoxine in treating malaria.
  • Storage/Disposal

    Sulfadoxine, Artesunate Tablets should be stored in a cool, dry area at room temperature, ideally between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity and protect it from light and moisture. Avoid storing them in the bathroom or kitchen, as these areas may expose the medication to heat and humidity. Always check the expiration date, and do not use the tablets if they are past their expiry. Dispose of any unused or expired tablets responsibly by returning them to a medication take-back program or following local guidelines for pharmaceutical waste disposal. Keep the medication away from children to prevent accidental consumption.

  • Quick Tips, if any

    Following are the quick tips for Sulfadoxine, Artesunate Tablet:

    • Always take the medication as directed by your doctor; do not adjust the dosage without medical advice.
    • Ensure you complete the full course of medication to achieve maximum effectiveness.
    • Swallow the tablet whole with a full glass of water; do not crush or chew.
    • Maintain a consistent schedule for taking the medication for best results.
    • Store the tablets in a cool, dry place, away from direct sunlight and moisture.
    • Inform your doctor about any other medications you are taking to prevent potential interactions.
    • Contact your healthcare provider if you experience any severe side effects or persistent symptoms.

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