ARTINIL K GEL

Diclofenac Potassium Gel acts by inhibiting the cyclooxygenase (COX) enzymes, primarily COX-2, which are responsible for the synthesis of prostaglandins. By blocking these enzymes, the gel reduces the production of prostaglandins at the site of application, which are key mediators of inflammation and pain. This inhibition of prostaglandin synthesis leads to a decrease in inflammation, swelling, and pain associated with various musculoskeletal conditions. Diclofenac's ability to target the COX-2 enzyme helps minimize the potential gastrointestinal side effects that can be associated with non-selective COX inhibitors.

Diclofenac Potassium

Nonsteroidal anti-inflammatory drug (NSAID)

Gel

The following are the uses of Diclofenac Potassium Gel:

• Used for relieving pain and reducing inflammation in joint and muscle conditions like arthritis, sprains, and strains.
• Used for treating acute pain and swelling due to minor injuries.
• Used for managing pain and inflammation post-surgery or after dental procedures.
• Used for providing targeted relief from pain and stiffness in specific areas.
• Used for easing symptoms of tendinitis, bursitis, and other soft tissue disorders.
• Used for reducing discomfort and inflammation in cases of gout attacks.
• Used for offering localized pain management during physical therapy or rehabilitation.

In the case of an overdose of Diclofenac Potassium Gel, it is important to recognize the signs and act promptly. Symptoms may include stomach pain, nausea, vomiting, and in severe cases, gastrointestinal bleeding. Seek medical assistance immediately if you suspect an overdose, as prompt treatment can help manage these symptoms effectively. The doctor will likely provide supportive care and monitor vital signs to ensure the patient's well-being.

In the case of a missed dose of Diclofenac Potassium Gel, it is important to apply the gel as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra gel to make up for the missed dose, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen.

To apply Diclofenac Potassium Gel, clean and dry the affected area, then gently massage a small amount of the gel onto the skin, ensuring it covers the entire painful area, and repeat this process 2 to 4 times daily, or as directed by your healthcare provider.

Following are the conditions or situations when Diclofenac Potassium Gel should not be applied:

• Should not be used on skin areas with open wounds, infections, or severe skin conditions like eczema or psoriasis.
• Contraindicated in individuals with a known allergy or sensitivity to Diclofenac or any non-steroidal anti-inflammatory drugs (NSAIDs).
• Not recommended for people with a history of asthma attacks or allergic reactions triggered by aspirin or other NSAIDs.
• Should not be applied on areas where there is a skin rash or skin reaction after recent use of other topical products.
• Avoid using on skin that will be exposed to direct sunlight or UV light, as it may increase sensitivity.
• Not suitable for individuals with severe kidney or liver disease.
• Should not be used on children and adolescents under 18 years of age.
• Contraindicated in pregnant and breastfeeding women.

The side effects of Diclofenac Potassium Gel may include:

• Skin redness or irritation at the application site
• Itching or rash
• Mild burning or stinging sensation
• Dry skin
• Swelling or fluid retention (edema)
• Stomach pain or discomfort
• Diarrhea or constipation
• Headache or dizziness

Following are the precautions and warnings for Diclofenac Potassium Gel:

• Avoid contact with eyes, nose, mouth, and other mucous membranes. Wash hands thoroughly after application to prevent accidental exposure.
• Do not apply to open wounds, infections, or irritated skin. Discontinue use if skin irritation or allergic reactions occur.
• Use the gel exactly as directed; do not apply more than the recommended amount or use it for longer than prescribed.
• Inform your doctor if you have a history of gastrointestinal problems, cardiovascular disease, or liver or kidney impairment.
• This medication may increase the risk of serious cardiovascular events, including heart attack and stroke. Monitor for signs and symptoms and seek immediate medical attention if any occur.
• Diclofenac gel may cause photosensitivity. Avoid excessive sunlight exposure and use sunscreen when outdoors.
• Pregnant and breastfeeding women should consult their healthcare provider before using this medication, as it may have potential risks for the fetus and infant.
• Keep out of reach of children and pets. Store the gel at room temperature, away from direct heat and moisture.

Following are the drug interactions for Diclofenac Potassium Gel:

• May interact with other non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, increasing the risk of gastrointestinal bleeding and kidney problems.
• Concomitant use with corticosteroids can increase the risk of gastrointestinal ulcers and bleeding.
• Using diclofenac with other blood thinners or anticoagulants may increase bleeding risk.
• Potentially dangerous interaction with lithium, leading to increased lithium levels and toxicity.
• Diclofenac may reduce the effectiveness of diuretics and antihypertensive medications, requiring careful monitoring.
• Can interact with methotrexate, increasing its toxicity and risk of side effects.
• Certain medications like ACE inhibitors and beta-blockers may have reduced efficacy when used with diclofenac.

Following are the food interactions to consider with Diclofenac Potassium Gel:

• Avoid excessive alcohol consumption while using this medication, as it can increase the risk of gastrointestinal bleeding and liver damage.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the metabolism of Diclofenac, potentially increasing its levels in the body and the risk of side effects.
• Avoid fatty or greasy foods, as they can slow down the absorption of Diclofenac, delaying its pain-relieving effects.
• Dairy products and calcium-rich foods may interact with Diclofenac, leading to reduced absorption, so it is best to take the medication at least 30 minutes before or after consuming dairy.
• Avoid spicy foods as they can irritate the stomach and increase the risk of gastrointestinal side effects when combined with Diclofenac.
• Caffeine intake should be monitored as it can enhance the stimulant effect of Diclofenac, potentially causing restlessness and sleep disturbances.
• Sugary foods and beverages should be consumed in moderation, as Diclofenac can sometimes mask the symptoms of high blood sugar.
• Always stay well-hydrated when using Diclofenac to reduce the risk of kidney-related side effects.

Diclofenac Potassium Gel should be stored in a cool and dry place, preferably at room temperature, ensuring it is kept away from direct sunlight, heat, and moisture. The gel should be stored in its original container, tightly sealed to maintain its integrity and prevent contamination. It is crucial to adhere to the storage instructions to preserve the effectiveness of the medication. When disposing of unused or expired gel, do not dispose of it in sinks, toilets, or drains. Instead, follow local guidelines or consult a pharmacist for safe disposal practices to minimize environmental impact. Keep the gel out of children's reach to prevent accidental exposure, ensuring their safety.

Following are the quick tips for Diclofenac Potassium Gel:

• Clean and dry the affected area before applying the gel.
• Use a sufficient amount of gel to cover the painful area, gently massaging it into the skin.
• Wash your hands thoroughly after application to avoid accidental contact with eyes or sensitive areas.
• Avoid applying the gel on broken or irritated skin.
• Do not cover the treated area with bandages or tight clothing to allow proper ventilation.
• Consult your healthcare provider if you experience skin irritation or redness.
• Store the gel at room temperature, away from direct sunlight and moisture.