ASTELIN NASAL SPRAY

Azelastine, the active ingredient in Azelastine Nasal Drops/Sprays, acts as a potent and selective antagonist of histamine H1 receptors. Its mechanism of action primarily involves blocking these receptors, which are widely distributed in the nasal mucosa. By binding to the H1 receptors, azelastine prevents histamine from activating them, thus inhibiting the release of inflammatory mediators responsible for allergic reactions. This process helps to alleviate symptoms such as sneezing, rhinorrhea (runny nose), and nasal itching associated with allergic rhinitis. Azelastine also demonstrates some anti-inflammatory properties, contributing to its effectiveness in reducing nasal congestion and other allergy-related symptoms.

Antihistamine nasal spray

Nasal Drop/Spray

The following are the uses of Azelastine Nasal Drop/Sprays:

• Used for relieving symptoms of seasonal allergic rhinitis, commonly known as hay fever.
• Used for treating itchy, runny, or stuffy nose due to allergies.
• Used to alleviate sneezing and itching in the nose.
• Effective for reducing inflammation in the nasal passages.
• Used to manage symptoms of allergic conjunctivitis affecting the eyes.
• Can be used for treating skin conditions like hives and itching.
• Provides quick relief from nasal discomfort during allergy seasons.
• Helps prevent allergy-related sleep disturbances.

In the case of an overdose of Azelastine Nasal Drop/Sprays, individuals may experience heightened side effects. These can include increased drowsiness, fatigue, and a potential feeling of sedation. It is important to recognize that excessive use of nasal sprays can lead to nasal irritation and discomfort. If an overdose is suspected, promptly contact a healthcare professional or a poison control center for guidance and further instructions to ensure appropriate management and care.

In the case of a missed dose of Azelastine Nasal Drop/Spray, it is important to administer the medication as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss several doses, consult your healthcare professional for advice on how to get back on track with your treatment plan and ensure optimal symptom relief.

To use Azelastine Nasal Drops/Sprays, gently blow your nose to clear the nostrils, tilt your head forward slightly, insert the dropper/spray nozzle into one nostril, and administer the prescribed number of drops/sprays while breathing gently through your nose, then repeat for the other nostril if directed.

Here are the conditions or situations when Azelastine Nasal Drop/Sprays should not be used:

• Do not use if you have a known allergy or hypersensitivity to Azelastine or any of the excipients in the nasal spray/drops.
• Avoid using if you have recently undergone nasal surgery or have untreated nasal infections or injuries.
• Not recommended for individuals with severe nasal congestion or nasal polyps, as it may not be able to reach the affected areas.
• Should not be used in children below the approved age (age varies depending on the product and region).
• Contraindicated in individuals with a history of nasal septum perforation or recent nasal surgery.

The side effects of Azelastine Nasal Drop/Sprays may include:

• Bitter taste or bad taste in the mouth
• Drowsiness or sleepiness
• Headache
• Fatigue or tiredness
• Nasal irritation or dryness
• Sneezing
• Sore throat
• Burning or itching sensation in the nose

Following are the precautions and warnings for Azelastine Nasal Drop/Sprays:

• This medication is for nasal use only; do not swallow or inject it.
• Do not share your nasal spray or dropper with others to prevent the spread of infection.
• Avoid spraying or dropping the medication into your eyes; if contact occurs, rinse thoroughly with water.
• If you have a history of nose injuries, surgery, or nasal problems, inform your doctor before using this medication.
• Children and elderly patients should use this medication under medical supervision and follow the prescribed dosage carefully.
• If symptoms persist or worsen after a few days of use, consult a healthcare professional.
• Discontinue use and seek medical attention if you experience severe side effects such as difficulty breathing, swelling of the face or throat, or severe skin reactions.

Following are the drug interactions for Azelastine Nasal Drop/Sprays:

• Alcohol and other central nervous system (CNS) depressants may increase sedation when taken with azelastine.
• Azelastine may reduce the effectiveness of beta-blockers, a class of drugs used to treat high blood pressure and heart conditions.
• The effects of azelastine may be decreased by antacids containing aluminum or magnesium, so separate administration by at least 2 hours.
• Caution is advised when using azelastine with anticholinergic drugs, as it may increase the risk of side effects like dry mouth, blurred vision, and urinary retention.
• Azelastine can increase the blood levels of ergot alkaloids, potentially leading to ergotism, a serious condition.
• Macrolide antibiotics such as erythromycin can increase the concentration of azelastine, possibly causing increased side effects.
• The use of azelastine with other antihistamines may increase the risk of drowsiness and impaired alertness.

Following are the food interactions for Azelastine Nasal Drop/Sprays:

• Avoid consuming alcohol as it may increase the risk of drowsiness and dizziness, especially when combined with this medication.
• Grapefruit and its juice should be consumed with caution as they can affect the metabolism of Azelastine, potentially increasing its levels in the body.
• Caffeine intake should be monitored as it may reduce the effectiveness of Azelastine in treating nasal symptoms.
• Spicy foods may trigger nasal irritation and worsen symptoms, so consider reducing their consumption during treatment.
• Dairy products, especially milk, might increase mucus production and potentially interfere with the medication's effectiveness.
• While not a direct food interaction, staying well-hydrated is essential to maintaining nasal moisture and overall health during Azelastine use.
• There are no specific food restrictions, but maintaining a balanced diet can support overall health and the body's response to the medication.

Azelastine Nasal Drops/Sprays should be stored properly to maintain their effectiveness and safety. Keep the medication in its original packaging, ensuring it is tightly sealed, and store it in a cool and dry place, preferably at room temperature, away from excessive heat, direct sunlight, and moisture. Avoid freezing the nasal spray as it may affect its consistency. Always check the expiration date, and do not use the medication if it is past its expiry. When disposing of unused or expired medication, do not flush it down the toilet or pour it into a drain. Consult your pharmacist or local waste disposal company for specific instructions on how to safely dispose of the nasal drops/sprays to minimize any potential environmental impact.

Following are the quick tips for Azelastine Nasal Drop/Sprays:

• Wash your hands before using the nasal spray to maintain hygiene.
• Prime the nasal spray before initial use or if not used for a prolonged period.
• Tilt your head slightly forward and insert the nasal applicator into one nostril.
• Spray the prescribed number of times while breathing gently through your nose.
• Alternate nostrils for each dose to ensure even distribution.
• Avoid blowing your nose immediately after using the spray for maximum effectiveness.
• Store the nasal spray at room temperature, away from direct sunlight and moisture.