Atizox (100mg/5ml) 30ml Suspension

Nitazoxanide, the active ingredient in Nitazoxanide 100mg Syrup/Suspension, primarily acts by inhibiting key enzymes involved in the synthesis of nucleic acids and energy metabolism in susceptible organisms. It specifically targets pyruvate-ferredoxin oxidoreductase (PFOR) and nitroreductases, which are crucial for energy production in anaerobic and microaerophilic pathogens. By disrupting these metabolic pathways, nitazoxanide interferes with the organisms' ability to generate ATP, leading to reduced pathogen viability. This mechanism of action contributes to its effectiveness against a range of parasites and certain bacteria, making it useful for treating various gastrointestinal infections.

Antiparasitic

Suspension

The following are the uses of Nitazoxanide 100mg Syrup/Suspension:

• Used for treating diarrhea caused by certain bacteria or parasites.
• Used for managing infections like Cryptosporidium and Giardia.
• Used for controlling inflammation in the intestines.
• Used for reducing stomach pain, nausea, and fever associated with infections.
• Used for pediatric patients to treat parasitic infections.
• Used for preventing and treating traveler's diarrhea.
• Used for eradicating certain types of worms from the body.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Adults and children above 12 years of age- Take 500 mg twice a day for 3 days.
• Children aged 1 to < 12 years- Take 500 mg once a day for 3 days.
• Children aged < 1 year- 5 mg/kg/day once a day for 3 days.

In the case of an overdose of Nitazoxanide 100mg Syrup/Suspension, prompt action is necessary. Symptoms may include nausea, vomiting, and abdominal pain. If ingestion is recent, inducing vomiting or administering activated charcoal may be advised. Medical professionals should closely monitor vital signs and provide supportive care. Quick response and appropriate treatment can help manage the adverse effects and ensure the patient's well-being.

In the case of a missed dose of Nitazoxanide 100mg Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember, provided it is not too close to the next scheduled dose. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you miss multiple doses or are unsure about how to adjust your medication regimen.

To administer Nitazoxanide 100mg Syrup/Suspension, shake the bottle well, measure the prescribed dose with an oral syringe or measuring cup, and give it to the patient by mouth, following the dosage instructions provided by the healthcare professional, with or without food, as directed.

Nitazoxanide 100mg Syrup/Suspension should not be used in the following circumstances:

• Must not be given to individuals with a known allergy or hypersensitivity to Nitazoxanide or any of the excipients in the formulation.
• Contraindicated in patients with severe liver disease or impaired liver function.
• Not recommended for individuals with rare hereditary problems of galactose intolerance, glucose-galactose malabsorption, or lactase deficiency.
• Should not be used in patients with a history of gastrointestinal diseases or conditions that could affect drug absorption.
• Contraindicated in patients with a history of severe diarrhea caused by certain infections or conditions.
• Not suitable for infants below 1 year of age due to the risk of potential side effects.

The side effects of Nitazoxanide 100mg Syrup/Suspension may include:

• Abdominal pain
• Diarrhea
• Nausea and vomiting
• Headache
• Dizziness
• Skin rash or itching
• Allergic reactions (rare)
• Changes in liver function (rare)

Following are the precautions and warnings for Nitazoxanide 100mg Syrup/Suspension:

• Not suitable for individuals with a known hypersensitivity or allergy to Nitazoxanide or any of the excipients in the suspension.
• Patients with a history of liver disease should use with caution, as liver function tests may be required during treatment.
• The syrup may cause dizziness or drowsiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Alcohol consumption should be avoided as it may worsen side effects.
• Nitazoxanide should be used with caution in elderly patients as they may be more susceptible to adverse effects.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as the risks and benefits should be carefully considered.
• This medication should not be used in children under 12 years of age without medical advice.
• Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency should exercise caution, as Nitazoxanide may cause hemolysis.

Following are the drug interactions for Nitazoxanide 100mg Syrup/Suspension:

• It may reduce the efficacy of oral contraceptives, so alternative birth control methods are recommended.
• Nitazoxanide can increase the concentration of statins, potentially leading to increased side effects.
• Avoid using with rifampicin, as it may reduce Nitazoxanide's effectiveness.
• Taking it with antacids may decrease its absorption, so separate administration by at least 2 hours.
• May increase the effects of anticoagulants, requiring close monitoring.
• Can enhance the concentration of anti-epileptic drugs, necessitating dosage adjustments.
• Co-administration with immunosuppressants may result in increased immunosuppression.

Following are the food interactions for Nitazoxanide 100mg Syrup/Suspension:

• Nitazoxanide can be taken with or without food, but taking it with food can help reduce stomach upset, which is a common side effect.
• Fatty meals or high-fat foods should be avoided as they may delay the absorption of Nitazoxanide, leading to reduced effectiveness.
• Grapefruit and grapefruit juice should be avoided as they can affect the metabolism of the drug, potentially increasing Nitazoxanide levels in the body.
• Alcohol consumption is not recommended as it may increase the risk of liver-related side effects and can also cause nausea and vomiting.
• Caffeine intake should be monitored as it can increase the likelihood of experiencing side effects such as tremors, restlessness, and insomnia.
• Dairy products like milk or yogurt can be consumed but may slightly reduce the absorption of Nitazoxanide, so it's best to take the medication 1-2 hours before or after dairy consumption.
• Avoid eating large meals right after taking the medication to ensure optimal absorption.
• Always follow the dosage instructions provided by your healthcare professional for the best results.

Nitazoxanide 100mg Syrup/Suspension should be stored in a secure location, preferably in a locked cabinet or a medicine storage box, away from direct sunlight, moisture, and extreme temperatures. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Do not refrigerate or freeze the suspension as it may affect its consistency. Always check the expiration date, and if the syrup has passed its expiry, do not use it and dispose of it carefully. For disposal, do not pour it down the drain or flush it; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption, and ensure responsible storage practices to maintain its effectiveness and safety.

Following are the quick tips for Nitazoxanide 100mg Syrup/Suspension:

• Always follow the dosage instructions provided by your doctor or pharmacist.
• Administer the syrup with a measuring device to ensure accurate dosing.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Do not freeze the medication, as it may affect its potency.
• Ensure the medication is out of children's sight and reach to prevent accidental consumption.
• If you notice any changes in the syrup's appearance or consistency, consult your pharmacist.
• Complete the full course of medication as prescribed, even if you feel better before finishing it.

Nitazoxanide is an anti-parasitic medication used to treat infections caused by protozoa and helminths. The tests required while taking Nitazoxanide 500mg depend on various factors, including the individual's age, weight, and medical history. While taking Nitazoxanide 500mg, it is crucial to monitor vital signs and perform a complete blood count (CBC) with differential. A CBC helps evaluate the blood's overall health, while the differential count highlights the percentage of each type of white blood cell, valuable for understanding the immune system's response to the parasite infection and the drug's impact on the bone marrow. Biochemical profiles to measure electrolytes, liver, and kidney function, urinalysis, and serum glucose levels are other essential lab tests. Parasitic infections can cause electrolyte imbalances, liver inflammation, and kidney disorders, and monitoring these helps identify adverse effects or underlying conditions that may require intervention or dosage adjustments. Relevant diagnostic imaging, such as abdominal and pelvic X-rays or ultrasounds, may be prescribed by a healthcare provider to monitor the response to Nitazoxanide 500mg treatment, helping to assess the infection's severity and determine if the medication's therapeutic levels are adequate. Consulting with a qualified medical professional is vital to assess the specific situation and adjust testing frequency based on the condition's severity and interpret the results relating to the treatment course.