Augmentin (457mg/5ml) 70ml Suspension

Co-amoxiclav 457mg/5ml Syrup/Suspension is a combination antibiotic that contains amoxicillin and clavulanic acid. Amoxicillin belongs to the penicillin class of antibiotics and works by inhibiting the synthesis of bacterial cell walls. It specifically targets the penicillin-binding proteins (PBPs), which are essential for cross-linking peptidoglycan strands in the bacterial cell wall. Clavulanic acid enhances the effectiveness of amoxicillin by inhibiting beta-lactamase enzymes produced by certain bacteria, which would otherwise break down amoxicillin and render it ineffective. Together, amoxicillin and clavulanic acid provide a broad spectrum of activity against a wide range of bacteria, including both Gram-positive and Gram-negative organisms, by disrupting their cell wall synthesis and preventing their growth and replication.

co-amoxicillin 457mg/5ml

Penicillin/beta-lactamase inhibitor

Suspension

The following are the uses of co-amoxicillin 457mg/5ml Syrup/Suspension:

• Used for treating bacterial infections in children, especially those affecting the ears, throat, and respiratory tract.
• Used for its effectiveness against a wide range of bacteria, making it a go-to choice for pediatricians.
• Used for managing acute otitis media (middle ear infection) in kids, reducing pain and inflammation.
• Used for respiratory tract infections like pneumonia and bronchitis, aiding in symptom relief.
• Used for its ability to fight bacterial strains that may be resistant to other antibiotics.
• Used for easy administration to children due to its syrup/suspension form, ensuring accurate dosage.
• Used for preventing the progression of minor infections into more severe conditions.

In the case of an overdose of co-amoxicillin 457mg/5ml syrup/suspension, immediate medical attention is necessary. Symptoms may include nausea, vomiting, diarrhea, and in severe cases, seizures or allergic reactions. The specific treatment will depend on the severity of the overdose and the patient's condition. Promptly seek medical advice, and provide the healthcare provider with details of the medication, dosage, and time of ingestion to ensure appropriate treatment and management.

In the case of a missed dose of co-amoxicillin 457mg/5ml Syrup/Suspension, it is important to administer the missed dose as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. For children, it is crucial to measure the dose accurately using a proper measuring device. Consult your healthcare provider if you frequently miss doses or have concerns about the medication's effectiveness.

To administer co-amoxicillin 457mg/5ml Syrup/Suspension, shake the bottle vigorously, measure the prescribed dose with an accurate measuring device like a marked measuring spoon or oral syringe, and administer the medication orally as directed by your healthcare professional, typically twice a day, with or without food, following the dosage instructions provided for your specific age and condition.

Following are the conditions/situations when co-amoxicillin 457mg/5ml Syrup/Suspension should not be taken:

• Avoid in patients with a history of allergic reactions to penicillins, cephalosporins, or any other beta-lactam antibiotics.
• Do not use if the patient has a known allergy to any of the components in the syrup/suspension.
• Not suitable for patients with a history of severe diarrhea or colitis associated with antibiotic use.
• Should be avoided in patients with mononucleosis.
• Contraindicated in patients with severe kidney disease or impairment.
• Not recommended for patients with a history of jaundice or liver problems associated with amoxicillin use.
• Avoid in patients with phenylketonuria as some formulations may contain phenylalanine.
• Do not administer to infants below a certain age (as specified by the manufacturer) without medical advice.

The side effects of co-amoxicillin 457mg/5ml Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Skin rash or itching
• Allergic reactions (such as hives, swelling, or difficulty breathing)
• Vaginal itching or discharge
• Fatigue or tiredness
• Headache
• Tooth discoloration (in children with developing teeth)

Following are the precautions and warnings for co-amoxicillin 457mg/5ml Syrup/Suspension:

• Do not use if you are allergic to penicillin antibiotics or any of the ingredients in the syrup.
• Ensure you complete the full prescribed course, even if you feel better, to prevent the risk of antibiotic resistance.
• Inform your doctor if you have kidney or liver problems as dosage adjustments may be necessary.
• This medication may cause diarrhea; if severe or persistent, contact your healthcare provider immediately.
• Avoid using this medication if you have a history of gastrointestinal issues, especially colitis.
• Alcohol consumption should be avoided or limited while taking this medication.
• Always shake the bottle well before each use to ensure a consistent dose.
• Store the medication properly, and check the expiration date before use.

Following are the drug interactions for Co-amoxicillin 457mg/5ml Syrup/Suspension:

• Co-amoxicillin may interact with oral contraceptives, potentially reducing their effectiveness. It is recommended to use additional contraceptive methods during treatment.
• Concurrent use with anticoagulants like warfarin may increase the risk of bleeding due to Co-amoxicillin's potential to affect vitamin K metabolism. Regular monitoring of INR is advised.
• Co-amoxicillin may interact with probenecid (used for gout), leading to increased levels of amoxicillin in the blood, which may enhance its effects and potential for side effects.
• Combining Co-amoxicillin with other antibiotics, especially bacteriostatic agents (e.g., tetracyclines, sulfonamides), may reduce the effectiveness of Co-amoxicillin.
• The effectiveness of Co-amoxicillin may be reduced when taken with antacids or medications that decrease stomach acidity (e.g., proton pump inhibitors, H2 antagonists).
• Co-amoxicillin should be used cautiously with other nephrotoxic drugs (e.g., aminoglycosides, diuretics), as it may increase the risk of kidney damage when used together.
• The use of Co-amoxicillin with methotrexate may increase the toxicity of methotrexate, as both drugs can affect kidney function. Close monitoring is required.
• Co-amoxicillin can alter the gut flora, potentially affecting the absorption of other medications, such as digoxin, leading to altered blood levels of these drugs.
• Co-amoxicillin may interact with allopurinol (used to treat gout), increasing the likelihood of developing a rash. The combination should be used cautiously.

Following are the food interactions for Co-amoxicillin 457mg/5ml Syrup/Suspension:

• Avoid consuming alcohol during the medication period as it may cause stomach upset and increase the risk of side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the absorption of the antibiotic, reducing its effectiveness.
• Dairy products like milk, yogurt, and cheese can decrease the absorption of amoxicillin, so it's best to take the medication 1-2 hours before or after consuming dairy.
• Antacids containing magnesium or aluminum may reduce the absorption of amoxicillin, so separate the intake of antacids and the medication by at least 2 hours.
• Vitamin C supplements or citrus fruits may slightly reduce the effectiveness of amoxicillin, so it's advisable to consume them at different times.
• High-fiber foods like whole grains, legumes, and nuts may decrease the absorption of amoxicillin. Consider taking the medication 1 hour before or 2 hours after meals.
• Iron supplements and multivitamins with minerals can interfere with amoxicillin absorption. Maintain a 2-hour gap between the medication and these supplements.
• No known severe food interactions affect the safety or efficacy of co-amoxicillin, but maintaining a balanced diet is essential for overall health during treatment.

Co-amoxicillin 457mg/5ml Syrup/Suspension should be stored in a controlled environment, preferably at room temperature between 20-25°C (68-77°F), away from direct exposure to sunlight, heat, and moisture. Keep the bottle tightly sealed to maintain its integrity and prevent contamination. Always check the expiration date, and do not use the medication if it has expired. When disposing of the syrup, do not pour it down the drain or flush it; instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for advice on proper disposal methods. Ensure that the medication is stored securely and kept out of the reach of children to prevent accidental consumption.

Following are the quick tips for Co-amoxicillin 457mg/5ml Syrup/Suspension:

• Always follow the dosage instructions provided by your doctor or pharmacist.
• Shake the bottle vigorously before each use to ensure proper mixing.
• Administer the syrup using the measuring cup or device provided to ensure accurate dosing.
• Take the entire prescribed dose; do not stop early, even if you feel better.
• Avoid taking it with acidic beverages like fruit juices, as they may interfere with absorption.
• Store the syrup in a cool, dry place, away from direct sunlight and heat.
• Keep a record of your doses to ensure you're taking it as directed.