AVASTIN 100MG/4ML INJ

Bevacizumab 100MG Injection, a monoclonal antibody, specifically targets and inhibits vascular endothelial growth factor (VEGF), a protein crucial for angiogenesis. By binding to VEGF, this medication blocks its interaction with VEGF receptors on the surface of endothelial cells, thereby inhibiting the signaling pathways responsible for stimulating the growth and development of new blood vessels. This mechanism effectively reduces the formation of blood vessels that supply oxygen and nutrients to tumors, leading to the inhibition of tumor growth and the normalization of the abnormal vasculature associated with certain cancers.

Bevacizumab 100MG

Bevacizumab is an anti-angiogenic.

Injection

The following are the uses of Bevacizumab 100MG Injection:

• Used for treating various cancers, primarily targeting blood vessel growth in tumors.
• Used for managing advanced colorectal, lung, brain, kidney, and ovarian cancers.
• Used for inhibiting tumor growth and spread by blocking angiogenesis.
• Used for improving patient outcomes and survival rates in combination with chemotherapy.
• Used for reducing abnormal fluid buildup in the chest cavity due to cancer.
• Used for enhancing vision in certain eye conditions related to blood vessel abnormalities.
• Used for slowing vision loss and improving eye health in wet age-related macular degeneration.
• Used for managing complications from advanced cancerous growths.

In the case of an overdose of Bevacizumab 100MG Injection, it is crucial to act swiftly. The effects of an overdose may include severe side effects such as high blood pressure, increased risk of bleeding, and potential damage to the heart and blood vessels. If you suspect an overdose, seek medical assistance immediately. Prompt action can help mitigate the risks associated with excessive medication intake, ensuring the patient receives the necessary care.

In the case of a missed dose of Bevacizumab 100MG Injection, it is important to consult your healthcare provider as soon as possible. They will provide guidance on how to handle the missed dose and whether you should take the injection as soon as you remember or if you should wait until the next scheduled dose. It is crucial not to double the dose to make up for a missed one without medical advice. If you miss a dose regularly, discuss adjusting your medication schedule with your doctor.

To administer Bevacizumab 100MG Injection, prepare the injection by drawing the prescribed dose into a syringe and inject it intravenously as directed by your healthcare professional, typically over a period of 90 minutes, following the recommended dosage and administration guidelines provided by your doctor.

Here are the conditions or situations when Bevacizumab 100MG Injection should not be administered:

• Must not be used in patients with a known allergy to Bevacizumab or any of its excipients.
• Contraindicated in patients with severe hypertension that is not controlled with medical treatment.
• Not suitable for individuals with recent or impending surgery, including surgery for gastrointestinal perforation.
• Should not be used in patients with significant bleeding disorders or active bleeding.
• Avoid using Bevacizumab in patients with serious infections or active infections requiring antibiotics.
• Contraindicated in pregnant women due to potential harm to the fetus.
• Not recommended for patients with significant cardiovascular diseases, such as recent heart attack or unstable angina.

The side effects of Bevacizumab 100MG Injection may include:

• Increased blood pressure
• Fatigue and weakness
• Loss of appetite
• Diarrhea
• Constipation
• Nausea and vomiting
• Mouth sores or ulcers
• Skin changes (dryness, itching, or rash)

Following are the precautions and warnings for Bevacizumab 100MG Injection:

• Patients with hypertension should be monitored closely as Bevacizumab can lead to increased blood pressure.
• Regular monitoring of blood pressure is essential during treatment, and hypertension should be controlled before starting the medication.
• This medication may increase the risk of bleeding, so patients with a history of bleeding disorders or recent surgery should be carefully evaluated.
• Avoid using Bevacizumab if you have a severe infection, as it can potentially mask the signs of infection or worsen existing infections.
• Patients should be monitored for signs of gastrointestinal perforation, and treatment should be discontinued if this occurs.
• It can impair wound healing, so surgical procedures should be scheduled carefully, and appropriate healing time should be allowed.
• Women of childbearing age should use effective contraception during treatment and for a period after completion to prevent potential harm to a developing fetus.

Following are the drug interactions for Bevacizumab 100MG Injection:

• Thrombolytic agents like alteplase may increase the risk of bleeding when used with Bevacizumab, as it can affect blood clotting.
• Bevacizumab may enhance the anticoagulant effect of warfarin, requiring close monitoring of coagulation parameters.
• Concomitant use with other anti-angiogenic drugs may increase the risk of arterial thromboembolic events.
• Caution with non-steroidal anti-inflammatory drugs (NSAIDs) as they may further increase bleeding risk.
• Interactions with immunosuppressants can occur, potentially affecting immune response.
• Certain chemotherapy drugs may have altered efficacy when combined with Bevacizumab.
• Prolonged use with corticosteroids may lead to increased risk of gastrointestinal perforation.

Following are the food interactions for Bevacizumab 100MG Injection:

• Avoid high-salt foods as they may increase blood pressure and fluid retention, potentially affecting the effectiveness of Bevacizumab.
• Consuming a diet rich in fruits and vegetables can provide antioxidants and support overall health during treatment.
• Grapefruit and grapefruit juice should be limited as they may affect drug metabolism and increase the risk of bleeding.
• Avoid alcohol consumption as it can increase the risk of gastrointestinal bleeding and interact with the medication's effects.
• Ensure adequate protein intake to support healing and tissue repair, but consult a dietician for personalized advice.
• Stay hydrated by drinking enough water, especially if experiencing diarrhea as a side effect.
• Maintain a balanced diet to ensure proper nutrition and support overall well-being during the treatment period.

Bevacizumab 100MG Injection should be stored in a controlled environment, preferably in a cool and dry place at room temperature, ensuring it is protected from direct sunlight, heat, and moisture. It is crucial to keep the injection in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Pay attention to the expiration date on the packaging and discard any unused or expired medication promptly. When disposing of Bevacizumab, avoid flushing it down the toilet or pouring it down the drain. Instead, consult a pharmacist or healthcare professional for appropriate disposal methods to ensure environmental safety. Keep the injection out of children's reach to prevent accidental exposure or ingestion.

Following are the quick tips for Bevacizumab 100MG Injection:

• This medication is typically administered by a healthcare professional in a medical setting.
• Ensure you inform your doctor about any allergies or medical conditions before treatment.
• It is important to disclose all medications you are currently taking to avoid potential interactions.
• During treatment, stay well-hydrated and maintain a balanced diet for optimal health.
• Regularly monitor your blood pressure and blood sugar levels as advised by your doctor.
• Report any vision changes, headaches, or unusual bleeding to your healthcare provider promptly.
• Follow your doctor's instructions for post-treatment care and attend all scheduled check-ups.