Avor (1mg) 100 Tablets

Lorazepam 1mg tablets exert their therapeutic effects primarily through their action on the central nervous system. The active ingredient, lorazepam, is a potent benzodiazepine that enhances the inhibitory effects of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter that inhibits the activity of neurons, and by facilitating its action, lorazepam reduces the excessive firing of neurons, leading to a calming effect. It selectively binds to specific benzodiazepine receptors located on GABA-A receptor complexes, increasing the frequency of chloride channel opening. This influx of chloride ions hyperpolarizes the neuron, making it more resistant to excitation, resulting in sedation, anxiolysis, muscle relaxation, and anticonvulsant effects. The mechanism of action contributes to the rapid onset of therapeutic effects, making lorazepam particularly useful in managing acute anxiety, insomnia, and seizure disorders.

Lorazepam 1mg

Benzodiazepine

Tablet

The following are the uses of Lorazepam 1mg Tablet:

• Used for managing anxiety disorders, providing short-term relief from excessive worry and tension.
• Used for treating insomnia, aiding in the initiation and maintenance of sleep.
• Used for pre-operative sedation, reducing anxiety and promoting relaxation before surgeries.
• Used for managing seizures, helping to control and prevent episodes in certain types of epilepsy.
• Used for providing relief during alcohol withdrawal, easing symptoms and preventing complications.
• Used for muscle relaxation, particularly in procedures requiring muscle tension relief.
• Used for managing nausea and vomiting, especially in chemotherapy patients.
• Used for its sedative properties, helping to calm and relax individuals in stressful situations.

To be taken strictly on the prescription of a doctor for the designated time in correct amounts.

In the case of an overdose of Lorazepam 1mg Tablets, individuals may experience severe symptoms including excessive drowsiness, confusion, and impaired coordination. They might also exhibit respiratory depression, leading to shallow or slow breathing. In extreme cases, an overdose can result in a coma or even prove fatal. Prompt medical intervention is necessary to manage the overdose effectively, with treatment potentially involving the administration of activated charcoal and close monitoring of vital signs in a hospital setting.

In the case of a missed dose of Lorazepam 1mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss several doses, contact your healthcare provider for advice on how to safely adjust your medication schedule.

To take Lorazepam 1mg Tablets, place the tablet under your tongue and allow it to dissolve completely, preferably without swallowing, following the dosage instructions provided by your healthcare professional.

Here are the conditions or situations when Lorazepam 1mg Tablet should not be taken:

• Avoid using Lorazepam if you have a known allergy or hypersensitivity to Lorazepam or any other benzodiazepines.
• Do not use if you have narrow-angle glaucoma.
• Contraindicated in patients with severe respiratory insufficiency or acute pulmonary insufficiency.
• Should not be used in individuals with severe liver disease or impaired liver function.
• Not recommended for patients with severe sleep apnea.
• Avoid if you have severe and advanced COPD (Chronic Obstructive Pulmonary Disease).
• Lorazepam is contraindicated in patients with a history of myasthenia gravis.
• Do not use if you have a history of acute intoxication with alcohol, narcotics, or other psychoactive substances.
• Not suitable for individuals with a history of drug or substance abuse.
• Should not be used in elderly patients or those with a history of severe depression or suicidal thoughts.

The side effects of Lorazepam 1mg Tablet may include:

• Drowsiness or sedation
• Weakness and fatigue
• Confusion or disorientation
• Impaired coordination and balance
• Memory problems or amnesia
• Dizziness
• Changes in appetite and weight
• Skin rashes or allergic reactions

Following are the precautions and warnings for Lorazepam 1mg Tablet:

• Do not consume alcohol while taking this medication, as it can increase the sedative effects and impair your ability to function.
• Avoid activities requiring mental alertness, such as driving or operating machinery, until you know how the medication affects you.
• Inform your doctor if you have a history of respiratory problems, as Lorazepam can suppress breathing.
• Use with caution in elderly patients, as they may be more sensitive to the effects and experience increased drowsiness and confusion.
• Not recommended for use in pregnant or breastfeeding women unless advised by a healthcare professional.
• Do not abruptly stop taking Lorazepam, as it may lead to withdrawal symptoms; consult your doctor for a proper tapering schedule.
• Keep this medication out of the reach of children and pets, as accidental ingestion can be harmful.

Following are the drug interactions for Lorazepam 1mg Tablet:

• Alcohol and other CNS depressants (e.g., opioids, barbiturates) can increase the sedative effects of lorazepam, leading to profound sedation and respiratory depression.
• Lorazepam can enhance the effects of other benzodiazepines and similar sedative-hypnotic drugs, potentially causing excessive drowsiness and impaired motor skills.
• The effectiveness of anticonvulsant medications may be reduced when used with lorazepam, requiring close monitoring for seizure control.
• Drugs that inhibit the enzyme CYP3A4 (e.g., ketoconazole, itraconazole) can increase lorazepam levels, leading to prolonged sedation and respiratory depression.
• Lorazepam may increase the concentration of certain antidepressants, such as fluoxetine and sertraline, by inhibiting their metabolism, potentially causing increased side effects.
• Combining lorazepam with clozapine or olanzapine may lead to excessive sedation, impaired motor function, and respiratory depression.
• Medications affecting liver enzymes, such as rifampicin, can decrease lorazepam levels, reducing its therapeutic effect.

Following are the food interactions for Lorazepam 1mg Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can lead to increased levels of Lorazepam in the blood, potentially causing enhanced sedation and other side effects.
• Alcohol is not recommended as it can exaggerate the sedative effects of Lorazepam, increasing the risk of dizziness, drowsiness, and impaired coordination.
• Consuming large amounts of caffeine may reduce the sedative effects of Lorazepam, making it less effective for treating anxiety or sleep disorders.
• Fatty foods can slow down the absorption of Lorazepam, potentially delaying its therapeutic effects.
• Avoid high-fat meals when taking Lorazepam to ensure optimal absorption and effectiveness.
• Lorazepam may interact with herbal supplements like St. John's Wort, potentially reducing its effectiveness and increasing side effects.
• Always inform your healthcare provider about any herbal supplements you are taking.
• No specific food restrictions are associated with Lorazepam, but maintaining a balanced diet is generally recommended.

Lorazepam 1mg Tablets should be stored in a secure and dry location, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It's crucial to avoid storing them in bathrooms or near heat-emitting appliances like heaters or ovens, as temperature fluctuations can impact their effectiveness. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Do not dispose of the tablets by flushing or pouring them down the drain; instead, consult a pharmacist or healthcare professional for safe disposal methods. Keep the medication away from children to prevent accidental ingestion.

Yes

Following are the quick tips for Lorazepam 1mg Tablet:

• Consult a doctor or pharmacist for personalized advice before taking this medication.
• Ensure you understand the dosage instructions and duration of treatment.
• Take the tablet by mouth as directed, usually 2 to 3 times a day.
• It can be taken with or without food, but taking it with food may prevent stomach upset.
• Avoid alcohol as it can increase the sedative effects of this medication.
• Do not drive or operate machinery until you know how this medicine affects you.
• Inform your doctor about all medications you are taking to prevent potential interactions.