AZENE SYP 60ML

Fluoxetine hydrochloride syrup/suspension, a selective serotonin reuptake inhibitor (SSRI), exerts its therapeutic effects primarily by selectively blocking the reabsorption of serotonin (5-hydroxytryptamine, 5-HT) in the brain. Serotonin is a neurotransmitter involved in mood regulation, and by inhibiting its reuptake, fluoxetine increases the availability of serotonin in the synaptic cleft. This leads to enhanced serotonin signaling, which is believed to contribute to the medication's antidepressant and anxiolytic properties. The mechanism involves binding to the serotonin transporter (SERT) and preventing serotonin molecules from being transported back into the presynaptic neuron, thereby prolonging their action and modulating neural circuits associated with mood and emotional responses.

Fluoxetine Hydrochloride

Selective Serotonin Reuptake Inhibitor (SSRI)

Suspension

The following are the uses of Fluoxetine Hydrochloride Syrup/Suspension:

• Used for treating depression, helping to alleviate symptoms and improve mood.
• Used for managing obsessive-compulsive disorder (OCD) by reducing intrusive thoughts and compulsive behaviors.
• Used for alleviating symptoms of panic disorder, including panic attacks and anxiety.
• Used for treating bulimia nervosa, assisting in reducing binge-eating and purging behaviors.
• Used for managing premenstrual dysphoric disorder (PMDD) to ease physical and emotional symptoms.
• Used for adolescents with depression, providing a safe and effective treatment option.
• Used for certain eating disorders, supporting recovery and healthy eating habits.
• Used for various other conditions as prescribed by healthcare professionals.

In the case of an overdose of Fluoxetine Hydrochloride Syrup/Suspension, immediate medical intervention is necessary. Symptoms may include nausea, vomiting, seizures, irregular heartbeat, and in severe cases, loss of consciousness. Promptly seek emergency care and provide healthcare professionals with information regarding the amount ingested and the time of overdose to ensure appropriate treatment and management.

In the case of a missed dose of Fluoxetine Hydrochloride Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is advisable to set a reminder or use a pill organizer to help you stay on track with your medication routine and minimize the chances of missing a dose.

To administer Fluoxetine Hydrochloride Syrup/Suspension, shake the bottle well, measure the prescribed dose using an oral syringe or a measuring cup, and take it orally once or twice a day, as directed by your healthcare provider, ensuring that you follow the dosage instructions and take it consistently at the same time each day.

Here are the conditions or situations when Fluoxetine Hydrochloride Syrup/Suspension should not be used:

• Avoid use in individuals with a known allergy to Fluoxetine or other selective serotonin reuptake inhibitors (SSRIs).
• Do not administer to patients who have shown hypersensitivity reactions to the syrup or its ingredients.
• Contraindicated in patients taking monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOIs.
• Should not be used in individuals with severe liver impairment.
• Not recommended for patients with a history of seizures or epilepsy.
• Avoid use in patients with narrow-angle glaucoma.
• Do not use in patients with a history of bleeding disorders or those taking anticoagulant medications.
• Contraindicated in individuals with a history of bone fractures or at high risk of osteoporosis.
• Should not be given to patients with diabetes as it may alter blood glucose levels.
• Avoid use in patients with severe kidney impairment.
• Not suitable for individuals with a history of manic episodes or bipolar disorder.

The side effects of Fluoxetine Hydrochloride Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea or constipation
• Loss of appetite
• Headaches or migraines
• Dizziness or lightheadedness
• Insomnia or sleep disturbances
• Agitation or restlessness
• Fatigue or weakness

Following are the precautions and warnings for Fluoxetine Hydrochloride Syrup/Suspension:

• Not suitable for individuals with a known allergy to Fluoxetine or any other ingredients in the medication.
• Requires caution in patients with a history of liver or kidney disease, as dosage adjustments may be necessary.
• Patients should inform their doctor if they have a history of seizures, diabetes, or glaucoma before starting this medication.
• Avoid alcohol consumption while taking Fluoxetine as it may increase the risk of side effects.
• May cause drowsiness or dizziness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Not recommended for use in children or adolescents unless under the supervision of a healthcare professional.
• Women who are pregnant, planning to become pregnant, or breastfeeding should consult their doctor before taking Fluoxetine, as it may have potential risks for the fetus or infant.

Following are the drug interactions for Fluoxetine Hydrochloride Syrup/Suspension:

• Concurrent use with other serotonergic agents like tricyclic antidepressants, fentanyl, lithium, tramadol, and tryptophan can lead to serotonin syndrome, a serious and potentially life-threatening condition.
• Contraindicated with Monoamine Oxidase Inhibitors (MAOIs), as it may cause severe reactions, including serotonin syndrome, increased body temperature, and seizures.
• May interact with anticoagulants such as warfarin, requiring close monitoring of coagulation parameters due to the potential for increased bleeding risk.
• Enhances the effects of CNS depressants like benzodiazepines, alcohol, and opioids, leading to increased sedation and impaired judgment.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal bleeding when taken with Fluoxetine.
• Can elevate blood levels of medications metabolized by the liver, including phenytoin, diazepam, and haloperidol, potentially requiring dosage adjustments.
• Prolongs the elimination of medications metabolized by CYP2D6, such as certain beta-blockers, antipsychotics, and antidepressants, leading to increased side effects.

Following are the food interactions for Fluoxetine Hydrochloride Syrup/Suspension:

• Grapefruit and grapefruit juice should be avoided as they may interfere with Fluoxetine's metabolism, potentially leading to increased drug levels in the blood and a higher risk of side effects.
• Alcohol consumption should be minimized or avoided as it can enhance the sedative effects of Fluoxetine, increasing the likelihood of dizziness, drowsiness, and impaired coordination.
• Consuming high-fat meals while taking Fluoxetine may slightly delay the absorption of the medication, but it does not significantly impact its overall effectiveness.
• Avoid excessive caffeine intake as Fluoxetine can increase caffeine's effects, leading to restlessness, rapid heartbeat, and anxiety.
• Foods rich in tyramine, such as aged cheeses, cured meats, and fermented foods, should be limited as Fluoxetine may interact with tyramine, causing a sudden increase in blood pressure.
• Maintain a balanced diet; Fluoxetine can sometimes affect appetite and weight, so a healthy diet is essential for managing these potential side effects.
• Avoid herbal supplements like St. John's Wort, as it may interfere with Fluoxetine's action, increasing the risk of serotonin syndrome.
• Always follow healthcare provider's advice regarding specific dietary restrictions or recommendations while taking Fluoxetine.

Fluoxetine Hydrochloride Syrup/Suspension should be stored in a secure location, preferably in a locked cabinet or container, away from unauthorized access. Keep it in a cool, dry area, maintaining a temperature between 15-30°C (59-86°F), and protect it from direct sunlight and moisture. Ensure the medication is tightly sealed in its original packaging to maintain its integrity. When disposing of Fluoxetine Hydrochloride Syrup/Suspension, do not pour it down the drain or flush it, as it can contaminate water sources. Instead, follow local guidelines or consult a pharmacist for safe disposal methods. It is crucial to keep this medication out of children's reach to prevent accidental consumption, which could be harmful.

Following are the quick tips for Fluoxetine Hydrochloride Syrup/Suspension:

• Always take the medication as prescribed by your doctor; do not adjust the dosage without medical advice.
• Measure the syrup accurately using the provided measuring cup or device.
• Store the medication at room temperature, away from direct sunlight and moisture.
• Ensure you complete the full prescribed course, even if you feel better before finishing it.
• Avoid alcohol consumption while taking this medication as it may intensify side effects.
• Regularly monitor your progress and inform your doctor if symptoms persist or worsen.
• If you experience any severe or unusual side effects, seek medical attention promptly.