Azintra (250mg) 60 Tablets

Azithromycin 250mg Tablet primarily exhibits its antibacterial activity through inhibition of protein synthesis in bacteria. It binds to the 50S subunit of the bacterial ribosome, preventing the translocation of aminoacyl tRNA, which is essential for the elongation step of protein synthesis. By interfering with this process, azithromycin disrupts the normal function of the bacterial ribosome, leading to the cessation of protein synthesis and ultimately resulting in bacterial cell death. This mechanism of action is selective for bacteria as it targets the distinct differences between bacterial and mammalian ribosomes, minimizing the impact on human cells. Azithromycin is particularly effective against a wide range of bacteria, including Gram-positive, Gram-negative, and atypical pathogens, due to its ability to penetrate into infected tissues and maintain high concentrations at the site of infection.

Azithromycin 250mg

Macrolide Antibiotic

Tablet

The following are the uses of Azithromycin 250mg Tablet:

• Used for treating bacterial infections, particularly those affecting the lungs and airways.
• Used for respiratory tract infections like pneumonia and bronchitis.
• Used for skin infections, such as cellulitis and folliculitis.
• Used for ear infections (otitis media) and sinus infections.
• Used for certain sexually transmitted infections, like chlamydia.
• Used for preventing and treating infections in patients with reduced immune function.
• Used for eradicating certain bacteria from the gut to prevent infections in specific medical conditions.
• Used for treating more severe infections as part of a combination therapy.

In the case of an overdose of Azithromycin 250mg Tablets, individuals may experience a range of symptoms. Common effects include gastrointestinal issues such as nausea, vomiting, and diarrhea. Additionally, some people might notice changes in their hearing, such as ringing in the ears or hearing loss. It is important to note that the severity of these symptoms can vary, and seeking medical advice promptly is recommended to ensure appropriate treatment and management of any adverse effects resulting from the overdose.

In the case of a missed dose of Azithromycin 250mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one. It is generally advised not to double the dose to make up for the missed dose, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to resume your medication schedule safely. They will provide specific instructions based on your medical condition and treatment plan.

To take Azithromycin 250mg Tablets, swallow the tablet whole with a full glass of water, preferably with food, once daily for the duration of the prescribed course, as directed by your healthcare professional.

Here are the situations when Azithromycin 250mg Tablet should not be used:

• Do not take if you have a known allergy to Azithromycin or any macrolide antibiotics.
• Avoid if you have a history of liver problems, especially jaundice or liver damage caused by previous azithromycin therapy.
• Do not use if you have a slow or irregular heart rhythm, or if you have a heart condition called QT prolongation.
• Contraindicated in patients with myasthenia gravis, as it can worsen muscle weakness.
• Should not be used in patients with a history of severe allergic reactions (anaphylaxis).
• Not recommended for patients with a history of pancreatitis, especially if it is related to previous azithromycin use.
• Avoid if you have certain electrolyte imbalances, such as low levels of potassium or magnesium in your blood.
• Do not take this medication if you are currently taking medications that can cause an irregular heartbeat, as it may increase the risk of this side effect.
• Contraindicated in patients with a history of liver disease or impaired liver function.

The side effects of Azithromycin 250mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Skin rashes or itching
• Fatigue and weakness
• Altered sense of taste

Following are the precautions and warnings for Azithromycin 250mg Tablet:

• Avoid using this medication if you have a known allergy to Azithromycin or similar antibiotics such as erythromycin.
• Inform your doctor if you have a history of liver or kidney disease, as close monitoring is required during treatment.
• Caution is advised for elderly patients, as they may be more susceptible to side effects.
• Azithromycin may cause QT prolongation, so patients with existing heart conditions should be closely monitored.
• Do not take antacids containing aluminum or magnesium within 2 hours of taking Azithromycin, as they can reduce its effectiveness.
• Patients with myasthenia gravis should exercise caution, as Azithromycin may worsen muscle weakness.
• This medication should be used with care in diabetic patients as it may affect blood sugar levels.

Following are the drug interactions for Azithromycin 250mg Tablet:

• Concomitant use with other antibiotics like erythromycin, clarithromycin, and certain antifungal drugs may increase the risk of cardiac side effects, including QT prolongation.
• Azithromycin can affect the metabolism of some drugs processed by the liver, including statins and anticoagulants, potentially altering their effectiveness.
• Nelfinavir, a protease inhibitor, can significantly increase azithromycin concentrations, which may lead to increased side effects.
• Antacids containing aluminum or magnesium may reduce the absorption of azithromycin when taken simultaneously, so they should be separated by at least 2 hours.
• The effectiveness of live bacterial vaccines may be reduced if administered within 2 weeks of starting azithromycin treatment.
• Caution is advised when combining azithromycin with drugs that prolong the QT interval, as this may further increase the risk of cardiac arrhythmias.
• Azithromycin may interact with certain anti-diabetic medications, such as insulin or sulfonylureas, potentially affecting blood sugar control.

Following are the food interactions for Azithromycin 250mg Tablet:

• Avoid consuming grapefruit and grapefruit juice as they can increase the concentration of the medicine in the blood, potentially leading to an increased risk of side effects.
• Alcohol consumption should be limited or avoided as it may cause liver-related side effects and increase the risk of gastrointestinal issues.
• Dairy products like milk, cheese, and yogurt may reduce the absorption of Azithromycin, so it is best to take the medicine 2 hours before or after consuming these foods.
• Avoid high-fat meals as they may delay the absorption of Azithromycin, potentially reducing its effectiveness.
• Caffeine-rich foods and beverages might increase the metabolism of Azithromycin, leading to reduced efficacy. Consider reducing caffeine intake during the treatment period.
• Avoid eating large quantities of fiber-rich foods like whole grains, beans, and certain vegetables as they can interfere with the absorption of the medicine.
• Some herbal supplements, particularly those containing St. John's Wort, may affect the metabolism of Azithromycin, so consult your healthcare provider before taking any herbal remedies.
• Always follow the advice of your healthcare professional regarding dietary restrictions and interactions to ensure the best treatment outcome.

Azithromycin 250mg Tablets should be stored in a cool, dry area, ideally at room temperature between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly sealed, and away from direct sunlight, moisture, and heat. It's important to maintain the integrity of the medication, so avoid storing it in the bathroom or kitchen, as these areas can have temperature fluctuations. Always check the expiration date, and do not use the medication if it is expired. For disposal, do not flush the tablets down the toilet or pour them into a drain. Instead, follow local guidelines for medication disposal or consult a pharmacist for safe and environmentally friendly disposal methods. Keep the medication out of reach of children and pets to prevent accidental consumption.

Following are the quick tips for Azithromycin 250mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Swallow the tablet whole with a full glass of water, preferably on an empty stomach.
• Maintain a consistent time for taking the medication each day.
• Complete the full course as prescribed, even if you feel better early on.
• Avoid antacids, dairy products, and citrus juices around the time of taking the tablet.
• Inform your doctor about any other medications you are taking to prevent potential interactions.
• Store the tablets at room temperature, away from moisture and light.