Bacticef (1.5g) 1 Injection

Cefoperazone is a third-generation cephalosporin antibiotic that exerts its bactericidal effect by binding to essential penicillin-binding proteins (PBPs) within bacterial cells, inhibiting cell wall synthesis. This disrupts the formation of the bacterial cell wall, leading to cell lysis. Sulbactam, a β-lactamase inhibitor, protects cefoperazone from degradation by inhibiting a wide range of β-lactamases, including those produced by many Gram-negative and Gram-positive bacteria. By inactivating β-lactamases, sulbactam enhances the activity of cefoperazone against susceptible organisms, making the combination effective against a broader spectrum of bacteria, including some β-lactamase-producing strains.

Cefoperazone 750mg, Sulbactam 750mg

Third-generation cephalosporin/beta-lactamase inhibitor.

Injection

The following are the uses of Cefoperazone 750mg, Sulbactam 750mg injection:

• Used for treating severe bacterial infections like abdominal infections, skin and soft tissue infections, and bone and joint infections.
• Used for combating infections caused by a wide range of bacteria, including those resistant to other antibiotics.
• Used for preventing surgical site infections, especially in high-risk procedures.
• Used for managing complicated intra-abdominal infections, ensuring better patient outcomes.
• Used for treating infections in patients with weakened immune systems, providing essential support.
• Used for controlling infections in critical cases, helping stabilize patients.
• Used for managing hospital-acquired infections, reducing their severity and spread.

In the case of an overdose of Cefoperazone 750mg and Sulbactam 750mg injection, prompt medical assessment is necessary. Symptoms may include gastrointestinal issues, neurological effects, and changes in vital signs. Treatment involves supportive care, with potential interventions like gastric lavage and monitoring of vital functions. It is crucial to seek emergency medical help and provide healthcare professionals with the details of the overdose for appropriate management.

In the case of a missed dose of Cefoperazone 750mg and Sulbactam 750mg injection, it is recommended to administer the missed dose as soon as possible. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume the medication. It is important to maintain a consistent dosing schedule for this medication to ensure its effectiveness.

To administer the Cefoperazone 750mg and Sulbactam 750mg injection, ensure the vial is at room temperature, clean the injection site with an alcohol swab, and inject the entire contents of the vial intramuscularly or intravenously as directed by your healthcare provider, typically once every 8 to 12 hours, following the prescribed dosage and duration of treatment.

Following are the conditions when Cefoperazone 750mg, Sulbactam 750mg injection should not be used:

• Should not be used in patients with a confirmed severe hypersensitivity reaction to Cefoperazone, Sulbactam, or other cephalosporin antibiotics.
• Contraindicated in patients with a history of severe allergic reactions to penicillins, as there is a potential for cross-reactivity.
• Not recommended for patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior cefoperazone/sulbactam therapy.
• Should be avoided in patients with severe renal impairment without adjusting the dose or frequency of administration.
• Not suitable for patients with a history of seizures or conditions that increase the risk of seizures.
• Should not be used in patients with confirmed or suspected bacterial infections caused by resistant organisms.
• Contraindicated during breastfeeding, as both Cefoperazone and Sulbactam can pass into breast milk.

The side effects of Cefoperazone 750mg, Sulbactam 750mg injection may include:

• Skin rash, itching, hives, swelling of the face, lips, or tongue.
• Nausea, vomiting, diarrhea, abdominal pain.
• Headache, dizziness, confusion, seizures (rarely).
• Pain, redness, swelling, or irritation at the injection site.
• Decreased white blood cell count, increased bleeding tendency, thrombocytopenia.
• Increased creatinine levels, acute kidney injury (rare).
• Overgrowth of non-susceptible microorganisms.
• Elevated liver enzymes, jaundice (rarely).

Following are the precautions and warnings for Cefoperazone 750mg, Sulbactam 750mg injection:

• Do not use if you are allergic to any penicillin-type medications or cephalosporin antibiotics.
• Inform your doctor about any medical history, especially kidney or liver disease, as dosage adjustments may be necessary.
• Use with caution in elderly patients as they may be more susceptible to side effects.
• This medication may cause diarrhea; prolonged or severe diarrhea may indicate a more serious condition.
• If you have a history of gastrointestinal diseases, monitor for potential side effects and consult your doctor.
• Pregnant and breastfeeding women should consult their healthcare provider before using this medication.
• Do not inject if the solution is cloudy or contains particles, and do not use beyond the expiration date.

Following are the drug interactions for Cefoperazone 750mg, Sulbactam 750mg injection:

• Probenecid may increase the blood levels of Cefoperazone, potentially enhancing its effects and side effects.
• Nephrotoxic drugs (e.g., aminoglycosides, loop diuretics) can increase the risk of kidney toxicity when used with Cefoperazone.
• Cefoperazone may reduce the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• Sulbactam may decrease the absorption of oral antidiabetic drugs, necessitating blood glucose monitoring.
• The combination of Cefoperazone and Sulbactam with other antibiotics may increase the risk of Clostridium difficile-associated diarrhea.
• Caution is advised when using with neuromuscular blocking agents, as it may prolong the duration of action.
• Concurrent use with anticoagulants may increase the risk of bleeding.

Following are the food interactions for Cefoperazone 750mg, Sulbactam 750mg injection:

• Avoid consuming alcohol during and a few days after the treatment, as it may cause an adverse reaction and increase the risk of side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the absorption and metabolism of Cefoperazone, potentially leading to increased drug levels in the body.
• High-fat meals may slightly delay the absorption of Cefoperazone, but it is generally well-tolerated and does not significantly affect its overall effectiveness.
• Avoid caffeinated beverages as they may increase the risk of side effects like nervousness, insomnia, and rapid heartbeat.
• Sulbactam may decrease the absorption of iron; ensure a sufficient gap between iron-rich foods and medication intake.
• Maintain a balanced diet and stay well-hydrated to support overall health during the treatment.
• Avoid natural licorice as it may interact with the medication and affect blood pressure.
• Consult your healthcare provider for specific dietary recommendations, especially if you have any underlying health conditions.

Cefoperazone 750mg, Sulbactam 750mg injection should be stored in a controlled environment, preferably at room temperature between 20-25°C (68-77°F). It is crucial to keep the injection away from direct sunlight, heat, and moisture to maintain its potency. Store the medication in its original packaging, ensuring it remains sealed and protected from contamination. Always check the expiration date before use and discard any expired or unused vials. Proper disposal of this medication is essential; do not throw it into the trash or pour it down the drain. Contact your healthcare provider or pharmacist for guidance on safe disposal methods. Keep the injection out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Cefoperazone 750mg, Sulbactam 750mg injection:

• Administer the injection as directed by your healthcare professional for the best therapeutic outcome.
• Ensure proper aseptic technique during administration to prevent infection.
• Confirm the patient's identity and verify the medication details before injecting.
• Choose the appropriate injection site and rotate sites to minimize discomfort.
• Discard any unused portion; do not reuse needles or syringes.
• Store the injection as directed on the packaging, away from light and moisture.
• In case of any adverse reaction, seek immediate medical attention.